Dr. Johnson’s Lab has reported on recent work, “The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography”, using Positron emission tomography (PET) to image tau protein deposition in the brain in Alzheimer’s disease (AD).
Sanchez, J.S., et al. (2021) The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography. Science Translational Medicine. doi.org/10.1126/scitranslmed.abc0655.
In Magnetic Resonance Imaging, Georges El Fakhri, PhD, director of the Gordon Center for Medical Imaging in the Department of Radiology at Massachusetts General Hospital, and Fang Liu, PhD, a researcher in the center, and colleagues describe their newest effort, a method that rapidly creates realistic MRI parameter maps by incorporating adversarial training into a previously created deep learning framework.
Dr. Jorge Sepulcre, an Assistant Professor of Radiology at HMS and Assistant in Neuroscience at the MGH Gordon Center, leads a lab that focuses on brain imaging studies aimed at the understanding of large-scale brain networks implicated in human cognition and neurodegenerative disorders. His article titled “Neurogenetic contributions to amyloid beta and tau spreading in the human […]
Dr. Jorge Sepulcre, an Assistant Professor of Radiology at HMS and Assistant in Neuroscience at the MGH Gordon Center. His research focuses on large-scale brain networks implicated in human cognition and neurodegenerative disorders. His article titled “Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain” has been published in Nature Communications on the 24th of […]
“PET staging of amyloidosis using striatum”: A new study published in Alzheimer’s and Dementia, the Journal of the Alzheimer’s Association, proposes to stage amyloid PET images using regional information. The research was conducted by Dr. Bernard Hanseeuw, instructor at MGH Gordon Center, and Dr. Keith Johnson, leader of the Aging NeuroImaging Program at the MGH Gordon Center, and the Harvard Aging Brain Study.
In a recent paper published by the journal Scientific Reports, Dr. Pedro Brugarolas and his colleagues describe the development and testing in animal models of a new PET tracer for demyelination. Their new tracer is based on the MS drug 4-aminopyridine (4AP, dalfampridine) which binds to potassium channels in demyelinated axons allowing the visualization of demyelinated lesions in animal models of MS noninvasively.
Dr. Heidi Jacobs along with Dr. Keith Johnson have published a paper in Nature Neuroscience entitled “Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals”.
This article was published in the Nuclear & Plasma Sciences Society newsletter of September 2017 Positron emission tomography (PET) enables 3D visualization of vital physiological information, e.g., metabolism, blood flow, and neuroreceptor concentration by using targeted radioisotope-labeled tracers. Quantitative interpretation of PET images is crucial both in diagnostic and therapeutic contexts. As a result of […]