Sepulcre Lab

About the lab

PI: Jorge Sepulcre

The Sepulcre lab focuses on brain imaging studies aiming at the understanding of large-scale brain networks implicated in human cognition and neurodegenerative disorders. We also devote a substantial part of our work developing cutting-edge network methodologies for different brain imaging modalities such as functional connectivity MRI and PET imaging.


Our specific research interest aligns with the following topics:

  • Systems Neuroscience
  • Brain Functional Streams
  • Brain Hierarchical Ormembganization
  • Multimodal Sensory Integration
  • Language Neuroarchitecture
  • Neurodegenerative Disorders

Link to research page.


Research Assistants

Selected Publications

  • Hong YJ, Kim CM, Lee JH, Sepulcre J. Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals. Sci Rep 2022 12 (1):14307
  • Montal V, Diez I, Kim CM, Orwig W, Bueichekú E, Gutiérrez-Zúñiga R, Bejanin A, Pegueroles J, Dols-Icardo O, Vannini P, El-Fakhri G, Johnson KA, Sperling RA, Fortea J, Sepulcre J. Network Tau spreading is vulnerable to the expression gradients of and glutamatergic-related genes. Sci Transl Med 2022 14 (655):eabn7273
  • Gutiérrez-Zúñiga R, Diez I, Bueichekú E, Kim CM, Orwig W, Montal V, Fuentes B, Díez-Tejedor E, Fernández MG, Sepulcre J. Connectomic-genetic signatures in the cerebral small vessel disease. Neurobiol Dis 2022 167 ():105671
  • Basaia S, Agosta F, Diez I, Bueichekú E, d’Oleire Uquillas F, Delgado-Alvarado M, Caballero-Gaudes C, Rodriguez-Oroz M, Stojkovic T, Kostic VS, Filippi M, Sepulcre J. Neurogenetic traits outline vulnerability to cortical disruption in Parkinson’s disease. Neuroimage Clin 2022 33 ():102941
  • Bueichekú E, Gonzalez-de-Echavarri JM, Ortiz-Teran L, Montal V, d’Oleire Uquillas F, De Marcos L, Orwig W, Kim CM, Ortiz-Teran E, Basaia S, Diez I, Sepulcre J. Divergent connectomic organization delineates genetic evolutionary traits in the human brain. Sci Rep 2021 11 (1):19692
  • Orwig W, Diez I, Bueichekú E, Vannini P, Beaty R, Sepulcre J. Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain. Front Hum Neurosci 2021 15 ():694274
  • Diez I, Sepulcre J. Unveiling the neuroimaging-genetic intersections in the human brain. Curr Opin Neurol 2021 34 (4):480-487
  • Kim CM, Montal V, Diez I, Orwig W, , Sepulcre J. Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging. Hum Brain Mapp 2021 42 (10):2990-3004
  • Orwig W, Diez I, Vannini P, Beaty R, Sepulcre J. Creative Connections: Computational Semantic Distance Captures Individual Creativity and Resting-State Functional Connectivity. J Cogn Neurosci 2021 33 (3):499-509
  • Diez I, Larson AG, Nakhate V, Dunn EC, Fricchione GL, Nicholson TR, Sepulcre J, Perez DL. Early-life trauma endophenotypes and brain circuit-gene expression relationships in functional neurological (conversion) disorder. Mol. Psychiatry 2020; ():
    View in: PubMed
  • Costumero V, d’Oleire Uquillas F, Diez I, Andorrà M, Basaia S, Bueichekú E, Ortiz-Terán L, Belloch V, Escudero J, Ávila C, Sepulcre J. Distance disintegration delineates the brain connectivity failure of Alzheimer’s disease. Neurobiol. Aging 2020; 88():51-60
    View in: PubMed
  • Bueichekú E, Aznárez-Sanado M, Diez I, d’Oleire Uquillas F, Ortiz-Terán L, Qureshi AY, Suñol M, Basaia S, Ortiz-Terán E, Pastor MA, Sepulcre J. Central neurogenetic signatures of the visuomotor integration system. Proc. Natl. Acad. Sci. U.S.A. 2020; 117(12):6836-6843
    View in: PubMed
  • Benito-Aragón C, Gonzalez-Sarmiento R, Liddell T, Diez I, d’Oleire Uquillas F, Ortiz-Terán L, Bueichekú E, Chow HM, Chang SE, Sepulcre J. Neurofilament-lysosomal genetic intersections in the cortical network of stuttering. Prog. Neurobiol. 2020; 184:101718
    View in: PubMed
  • Bueichekú E, Ávila C, Miró-Padilla A, Sepulcre J. Visual search task immediate training effects on task-related functional connectivity. Brain Imaging Behav 2019; 13(6):1566-1579
    View inPubMed
  • Qian J, Diez I, Ortiz-Terán L, Bonadio C, Liddell T, Goñi J, Sepulcre J. Positive Connectivity Predicts the Dynamic Intrinsic Topology of the Human Brain Network. Front Syst Neurosci 2018; 12:38
    View inPubMed
  • Diez I, Sepulcre J. Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain. Nat Commun 2018; 9(1):3876
    View inPubMed
  • Ruiz de Miras J, Costumero V, Belloch V, Escudero J, Ávila C, Sepulcre J. Complexity analysis of cortical surface detects changes in future Alzheimer’s disease converters. Hum Brain Mapp 2017; 38(12):5905-5918
    View in: PubMed
  • Ortiz-Terán L, Diez I, Ortiz T, Perez DL, Aragón JI, Costumero V, Pascual-Leone A, El Fakhri G, Sepulcre J. Brain circuit-gene expression relationships and neuroplasticity of multisensory cortices in blind children. Proc. Natl. Acad. Sci. U.S.A. 2017; 114(26):6830-6835
    View in: PubMed
  • Sepulcre J, Grothe MJ, Sabuncu M, Chhatwal J, Schultz AP, Hanseeuw B, El Fakhri G, Sperling R, Johnson KA. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurol 2017; 74(7):813-820
    View in: PubMed
  • Prčkovska V, Huijbers W, Schultz A, Ortiz-Teran L, Peña-Gomez C, Villoslada P, Johnson K, Sperling R, Sepulcre J. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Hum Brain Mapp 2017; 38(4):1965-1976
    View in: PubMed
  • Ortiz-Teran L, Ortiz T, Perez DL, Aragon JI, Diez I, Pascual-Leone A, Sepulcre J. Brain Plasticity in Blind Subjects Centralizes Beyond the Modal Cortices. Front Syst Neurosci 2016; 10():61
  • Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. J. Neurosci. 2016; 36(28):7364-74
  • Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann. Neurol. 2016; 79(1):110-9
  • Hu C, Sepulcre J, Johnson KA, Fakhri GE, Lu YM, Li Q. Matched signal detection on graphs: Theory and application to brain imaging data classification. Neuroimage 2016; 125():587-600
  • Sepulcre J, Masdeu JC. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease. Methods Mol. Biol. 2016; 1303():509-19
  • Sepulcre J. An OP4 functional stream in the language-related neuroarchitecture. Cereb. Cortex 2015; 25(3):658-66
  • Sepulcre J. Functional streams and cortical integration in the human brain. Neuroscientist. 2014 Oct; 20(5):499-508.
  • Sepulcre J. Integration of visual and motor functional streams in the human brain. Neuroscience Letters. 2014 May 1; 567:68-73.

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