Research at CMITT involves both Technology Research and Development (TR&D) as well as Collaborative Projects and Service Projects to further the aims of developing and applying cutting-edge imaging technologies that take advantage of the game-changing capabilities afforded by simultaneous quantitative PET/MR.

TR&D Projects

Ultra-Fast Multiparametric MR Imaging Methods

TR&D 1

We are developing several powerful MR technologies to enhance PET/MR for physiological imaging.

Our aims are to

• Develop a free-running, three-dimensional, multi-parametric, cardiac MRI method for motion-corrected whole-heart membrane potential imaging using PET/MR

• Develop high-resolution MRSI for multi-modality, multi-molecular imaging using PET/MR

• Develop ultra-fast, multi-component MR relaxometry using deep learning and MR physics modeling

Selected results

Advanced Statistical Image Reconstruction & Physics Informed AI

TR&D 2

We are developing an innovative physics-informed AI-based pipeline of data processing in PET/MR, including image reconstruction, transfer learning, and uncertainty estimation.

Our aims are to

• Develop a deep-learning-based image reconstruction that incorporates anatomic MR image and motion correction for both cross-sectional and longitudinal studies.

• Develop domain adaptation (DA) and DA few shot learning (DA-FSL) in PET/MR.

• Develop a DL-based approach to estimate the posterior distribution of PET image.

Selected results

Novel Imaging Agents & Physiological Modeling

TR&D 3

We are developing radiotracers and PET/MR imaging methods for measuring cellular membrane potential in the myocardium and mitochondrial membrane potential outside the heart, demyelination in the brain, and immune function throughout the body.

Our aims are to

• Quantitatively map membrane potential

• Image potassium channels as a novel biomarker for demyelination

• Develop a nanoparticle-based platform for specific imaging of the immune response

Selected Results

Previous funding cycle aims

TR&D 1

Motion Correction in PET/MR

TR&D 2

Unified Joint Statistical Reconstruction of PET & MR

TR&D 3

Pharmacokinetic Physiologic Modeling in Simultaneous PET/MR

Collaborative Projects

Collaborative Projects (CPs) serve as technology drivers, users, and testbeds for the cutting-edge technology developed in Technology Research and Development (TR&D) projects.

CMITT will develop and optimize new PET/MR tools and methods for the biomedical research problems addressed by the projects listed at the link.

Service Projects

Service Projects (SPs) serve as users of the well-developed and stable technologies of CMITT.

Our overall goal is to serve the clinical and research PET/MR communities by providing access to state-of-the art PET/MR technology both on the software side (quantitation and reconstruction methods, kinetic modeling tools) as well as the hardware/radiochemistry versant (micro-coils, dual PET-MR probes).

Our service activities can be described in three categories: 1) Regional service that enables clinical and pre-clinical PET/MR research; 2) On-site service that enables the deployment of specific software and radiopharmaceuticals using physical resources such as radiopharmacy labs, PET/MR scanner, supercomputers with very large flat physical memory; and 3) Electronic support for research using the electronically downloadable software that will be developed for motion, attenuation and PSF quantitation, PET/MR reconstruction, kinetic modeling, etc.

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Locations of our current CPs and SPs

Click on a location for information