David R. Elmaleh

David Elmaleh


Associate Professor of Radiology


1971 Ph.D. in Organic Chemistry Hebrew University, Jerusalem, Israel

Contact Info

Wellman 5th Floor
55 Fruit Street
Boston, MA 02114


See Harvard Catalyst for publications

Professional Positions

1971-1973Instructor in the Casali Institute of Applied Chemistry and Assistant to the Director, the late Professor J.E. Jolles, Hebrew University of Jerusalem
1975-1976Research Associate, Department of Medicinal Chemistry and Pharmacology, College of Pharmacy and Allied Health Professions, Northeastern University, Boston, MA; the synthesis of CNS drugs with Professor J.L. Neumeyer
1976-1978Assistant in Chemistry, Department of Radiology, Massachusetts General Hospital, Boston, MA
1978-1980Assistant Chemist, Department of Radiology, Massachusetts General Hospital, Boston, MA
1978Research Member, Harvard MIT Division of Health Sciences and Technology, Cambridge, MA
1980Associate Radiochemist, Department of Radiology, Physics Research Laboratory, Massachusetts General Hospital, Boston, MA
1981-1985Assistant Professor of Radiology, Harvard Medical School, Boston, MA
1984Director, Contrast Media Chemistry, Division of Radiological Sciences, Department of Radiology, Massachusetts General Hospital, Boston, MA
1984Associate Professor of Radiology, Harvard Medical School Boston, MA

Other Appointments

1995-2000Member, Scientific Advisory Board, IGG International, Boston, MA
1997-2002Chairman, Director and Scientific Founder, Biostream Inc. (currently Molecular Insight Pharmaceuticals, Inc.), Cambridge, MA
1998Director, US Biosystems, Boca- Raton, FL
1999Member of three NIH study sections (RO1, SBIR, R21, R33 )
2000-2001Founder, Director, Scientific Advisory Board, Nanopharma LLC (Currently Mersana Inc.) Cambridge, MA
2000Scientific Advisory Board, Puretech Ventures LLC (Boston MA)
2004-2012Founder, Director, Scientific Advisory Board, FluoroPharma Inc. (Boston, MA)
2011Founder, Director, Scientific Advisor, AZTherapies Inc., (Boston, MA)

Awards and Honors

  • The Histraduth Young Scientist Award
  • The Kathelyne Casali Award for Applied Chemistry
  • Several NIH RO1, DOE and SBIR awards

Major areas of interest and future goals

  • Capture medical technologies at their inception for developing novel drugs and healthcare products for the future
  • Focusing on improving human health care using novel approaches for early diagnosis and follow-up treatment
  • Clinical trial design for Alzheimer’s treatment
  • Drug design and discovery
  • Radiopharmaceutical development, biological evaluation of new agents
  • Radioactive tracer kinetic analysis in physiology and medicine
  • Development of agents and/or biomarkers for assessment of (a) central nervous system receptors, energy metabolism and cerebral blood flow, (b) myocardial function
  • Drug/Device applications in Medicine


partial list of 116 patents

US20140140927Cromolyn derivatives and their related methods of imaging and treatment (2014)
WO2010088455Preparation of cromolyn derivatives as imaging and pharmaceutical agents (2010)
US20090191125A1Diagnostic and Therapeutic Alkyl Piperidine/Piperazine Compounds and Process Compounds and Process (2009)
WO2009117728Compounds and compositions for the detection and treatment of Alzheimer’s disease and related disorders (2009)
US2008267879Novel imaging tracers for early detection and treatment of amyloid plaques caused by Alzheimer’s disease and related disorders (2008)
US7438893Polybiotin Compounds for magnetic resonance imaging and drug delivery (2008)
US7438891Imaging Agents for early detection and monitoring of cardiovascular plaque (2008)
WO2007123934Aryl bidentate isonitrile radionuclide metal chelate compounds and conjugates, and their uses for diagnostic and therapeutic purposes (2007)
US20060035828A1Direct activation of AtIII in whole blood and plasma (2006)
WO2005082425Catalytic radiofluorination (2005)