Gordon Center for Medical Imaging

Knierim M, Bommer T, Paulus M, Riedl D, Fink S, Pöppl A, Reetz F, Wang P, Maier L, Voigt N, Nahrendorf M, Sossalla S, Streckfuss-Bömeke K, Pabel S

Cellular calcium handling and electrophysiology are modulated by chronic physiological pacing in human induced pluripotent stem cell-derived cardiomyocytes.

Am J Physiol Heart Circ Physiol. 2024;327(5):H1244-H1254 - PMID: 39302711 - DOI: 10.1152/ajpheart.00536.2024

Grune J, Bajpai G, Ocak PT, Kaufmann E, Mentkowksi K, Pabel S, Kumowski N, Pulous FE, Tran KA, Rohde D, Zhang S, Iwamoto Y, Wojtkiewicz GR, Vinegoni C, Green U, Swirski FK, Stone JR, Lennerz JK, Divangahi M, Hulsmans M, Nahrendorf M

Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart.

Circulation. 2024;150(1):49-61 - PMID: 38506045 - PMCID: PMC11216864 - DOI: 10.1161/CIRCULATIONAHA.123.066433

Liu X, Shih HA, Xing F, Santarnecchi E, El Fakhri G, Woo J

Incremental Learning for Heterogeneous Structure Segmentation in Brain Tumor MRI.

Med Image Comput Comput Assist Interv. 2023;14221:46-56 - PMID: 38665992 - PMCID: PMC11045038 - DOI: 10.1007/978-3-031-43895-0_5

Zeller MWG, Wang C, Keliher EJ, Wojtkiewicz GR, Aguirre A, Maresca K, Su C, Buckbinder L, Wang J, Nahrendorf M, Chen JW

Myeloperoxidase PET Imaging Tracks Intracellular and Extracellular Treatment Changes in Experimental Myocardial Infarction.

Int J Mol Sci. 2023;24(6):ePub - PMID: 36982778 - PMCID: PMC10057533 - DOI: 10.3390/ijms24065704

Zhang S, Paccalet A, Rohde D, Cremer S, Hulsmans M, Lee IH, Mentkowski K, Grune J, Schloss MJ, Honold L, Iwamoto Y, Zheng Y, Bredella MA, Buckless C, Ghoshhajra B, Thondapu V, van der Laan AM, Piek JJ, Niessen HWM, Pallante F, Carnevale R, Perrotta S, Carnevale D, Iborra-Egea O, Muñoz-Guijosa C, Galvez-Monton C, Bayes-Genis A, Vidoudez C, Trauger SA, Scadden D, Swirski FK, Moskowitz MA, Naxerova K, Nahrendorf M

Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction.

Nat Cardiovasc Res. 2023;2(12):1277-1290 - PMID: 38344689 - PMCID: PMC10857823 - DOI: 10.1038/s44161-023-00388-7

Gustafsson K, Rhee C, Frodermann V, Scadden EW, Li D, Iwamoto Y, Palchaudhuri R, Hyzy SL, Boitano AE, Nahrendorf M, Scadden DT

Clearing and replacing tissue-resident myeloid cells with an anti-CD45 antibody-drug conjugate.

Blood Adv. 2023;7(22):6964-6973 - PMID: 37748049 - PMCID: PMC10690556 - DOI: 10.1182/bloodadvances.2023010561

Maier A, Toner YC, Munitz J, Sullivan NAT, Sakurai K, Meerwaldt AE, Brechbühl EES, Prévot G, van Elsas Y, Maas RJF, Ranzenigo A, Soultanidis G, Rashidian M, Pérez-Medina C, Heo GS, Gropler RJ, Liu Y, Reiner T, Nahrendorf M, Swirski FK, Strijkers GJ, Teunissen AJP, Calcagno C, Fayad ZA, Mulder WJM, van Leent MMT

Multiparametric Immunoimaging Maps Inflammatory Signatures in Murine Myocardial Infarction Models.

JACC Basic Transl Sci. 2023;8(7):801-816 - PMID: 37547068 - PMCID: PMC10401290 - DOI: 10.1016/j.jacbts.2022.12.014

Bapat A, Schloss MJ, Yamazoe M, Grune J, Hulsmans M, Milan DJ, Nahrendorf M, Ellinor PT

A Mouse Model of Atrial Fibrillation in Sepsis.

Circulation. 2023;147(13):1047-1049 - PMID: 36972346 - PMCID: PMC10057612 - DOI: 10.1161/CIRCULATIONAHA.122.060317

Hegemann N, Sang P, Kim JH, Koçana C, Momin N, Klages J, Kucherenko MM, Knosalla C, O'Brien B, Simmons S, Nahrendorf M, Kuebler WM, Grune J

Ultrasonographic assessment of pulmonary and Central venous congestion in experimental heart failure.

Am J Physiol Heart Circ Physiol. 2023;326(2):H433-H440 - PMID: 38099848 - PMCID: PMC11219047 - DOI: 10.1152/ajpheart.00735.2023

Mazzitelli JA, Pulous FE, Smyth LCD, Kaya Z, Rustenhoven J, Moskowitz MA, Kipnis J, Nahrendorf M

Skull bone marrow channels as immune gateways to the central nervous system.

Nat Neurosci. 2023;26(12):2052-2062 - PMID: 37996526 - PMCID: PMC10894464 - DOI: 10.1038/s41593-023-01487-1

Gustafsson K, Rhee C, Frodermann V, Scadden EW, Li D, Iwamoto Y, Palchaudhuri R, Hyzy SL, Boitano AE, Nahrendorf M, Scadden DT

CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer.

bioRxiv. 2023;:ePub - PMID: 37732224 - PMCID: PMC10508759 - DOI: 10.1101/2023.09.05.556397

Rhee C, Scadden EW, Wong LP, Schiroli G, Mazzola MC, Chea PL, Kato H, Hoyer FF, Mistry M, Lee BK, Kim J, Nahrendorf M, Mansour MK, Sykes DB, Sadreyev RI, Scadden DT

Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors.

Blood. 2023;142(7):658-674 - PMID: 37267513 - PMCID: PMC10447620 - DOI: 10.1182/blood.2023020257

Kiss MG, Mindur JE, Yates AG, Lee D, Fullard JF, Anzai A, Poller WC, Christie KA, Iwamoto Y, Roudko V, Downey J, Chan CT, Huynh P, Janssen H, Ntranos A, Hoffmann JD, Jacob W, Goswami S, Singh S, Leppert D, Kuhle J, Kim-Schulze S, Nahrendorf M, Kleinstiver BP, Probert F, Roussos P, Swirski FK, McAlpine CS

Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.

Immunity. 2023;56(7):1502-1514.e8 - PMID: 37160117 - PMCID: PMC10524830 - DOI: 10.1016/j.immuni.2023.04.013

Janssen H, Kahles F, Liu D, Downey J, Koekkoek LL, Roudko V, D'Souza D, McAlpine CS, Halle L, Poller WC, Chan CT, He S, Mindur JE, Kiss MG, Singh S, Anzai A, Iwamoto Y, Kohler RH, Chetal K, Sadreyev RI, Weissleder R, Kim-Schulze S, Merad M, Nahrendorf M, Swirski FK

Monocytes re-enter the bone marrow during fasting and alter the host response to infection.

Immunity. 2023;56(4):783-796.e7 - PMID: 36827982 - PMCID: PMC10101885 - DOI: 10.1016/j.immuni.2023.01.024

Liu T, Meng Z, Liu J, Li J, Zhang Y, Deng Z, Luo S, Wang M, Huang Q, Zhang S, Fendt P, Devouassoux J, Li D, McKenzie ANJ, Nahrendorf M, Libby P, Guo J, Shi GP

Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells.

Cardiovasc Res. 2023;119(4):1046-1061 - PMID: 36063432 - PMCID: PMC10153644 - DOI: 10.1093/cvr/cvac144

Hulsmans M, Schloss MJ, Lee IH, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous FE, Keller D, Bening C, Green U, Lennerz JK, Mitchell RN, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong CS, Pierson RN, Aster JC, Rohde D, Wojtkiewicz GR, Weissleder R, Swirski FK, Tellides G, Tolis G, Melnitchouk S, Milan DJ, Ellinor PT, Naxerova K, Nahrendorf M

Recruited macrophages elicit atrial fibrillation.

Science. 2023;381(6654):231-239 - PMID: 37440641 - PMCID: PMC10448807 - DOI: 10.1126/science.abq3061

Senders ML, Calcagno C, Tawakol A, Nahrendorf M, Mulder WJM, Fayad ZA

PET/MR imaging of inflammation in atherosclerosis.

Nat Biomed Eng. 2022;7(3):202-220 - PMID: 36522465 - DOI: 10.1038/s41551-022-00970-7

Steffens S, Nahrendorf M, Madonna R

Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies.

Eur Heart J. 2022;43(16):1533-1541 - PMID: 34897403 - PMCID: PMC9020986 - DOI: 10.1093/eurheartj/ehab842

McAlpine CS, Kiss MG, Zuraikat FM, Cheek D, Schiroli G, Amatullah H, Huynh P, Bhatti MZ, Wong LP, Yates AG, Poller WC, Mindur JE, Chan CT, Janssen H, Downey J, Singh S, Sadreyev RI, Nahrendorf M, Jeffrey KL, Scadden DT, Naxerova K, St-Onge MP, Swirski FK

Sleep exerts lasting effects on hematopoietic stem cell function and diversity.

J Exp Med. 2022;219(11):ePub - PMID: 36129517 - PMCID: PMC9499822 - DOI: 10.1084/jem.20220081

Bapat A, Li G, Xiao L, Yeri A, Hulsmans M, Grune J, Yamazoe M, Schloss MJ, Iwamoto Y, Tedeschi J, Yang X, Nahrendorf M, Rosenzweig A, Ellinor PT, Das S, Milan D

Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation.

JCI Insight. 2022;7(19):ePub - PMID: 35998035 - PMCID: PMC9675459 - DOI: 10.1172/jci.insight.160885

Grune J, Lewis AJM, Yamazoe M, Hulsmans M, Rohde D, Xiao L, Zhang S, Ott C, Calcagno DM, Zhou Y, Timm K, Shanmuganathan M, Pulous FE, Schloss MJ, Foy BH, Capen D, Vinegoni C, Wojtkiewicz GR, Iwamoto Y, Grune T, Brown D, Higgins J, Ferreira VM, Herring N, Channon KM, Neubauer S, Oxford Acute Myocardial Infarction (OxAMI) Study, Sosnovik DE, Milan DJ, Swirski FK, King KR, Aguirre AD, Ellinor PT, Nahrendorf M

Neutrophils incite and macrophages avert electrical storm after myocardial infarction.

Nat Cardiovasc Res. 2022;1(7):649-664 - PMID: 36034743 - PMCID: PMC9410341 - DOI: 10.1038/s44161-022-00094-w

Chaffin M, Papangeli I, Simonson B, Akkad AD, Hill MC, Arduini A, Fleming SJ, Melanson M, Hayat S, Kost-Alimova M, Atwa O, Ye J, Bedi KC, Nahrendorf M, Kaushik VK, Stegmann CM, Margulies KB, Tucker NR, Ellinor PT

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.

Nature. 2022;608(7921):174-180 - PMID: 35732739 - DOI: 10.1038/s41586-022-04817-8

Poller WC, Downey J, Mooslechner AA, Khan N, Li L, Chan CT, McAlpine CS, Xu C, Kahles F, He S, Janssen H, Mindur JE, Singh S, Kiss MG, Alonso-Herranz L, Iwamoto Y, Kohler RH, Wong LP, Chetal K, Russo SJ, Sadreyev RI, Weissleder R, Nahrendorf M, Frenette PS, Divangahi M, Swirski FK

Brain motor and fear circuits regulate leukocytes during acute stress.

Nature. 2022;607(7919):578-584 - PMID: 35636458 - PMCID: PMC9798885 - DOI: 10.1038/s41586-022-04890-z

Libby P, Nahrendorf M, Swirski FK

Mischief in the marrow: a root of cardiovascular evil.

Eur Heart J. 2022;43(19):1829-1831 - PMID: 35567561 - DOI: 10.1093/eurheartj/ehac149

Pulous FE, Cruz-Hernández JC, Yang C, Kaya Ζ, Paccalet A, Wojtkiewicz G, Capen D, Brown D, Wu JW, Schloss MJ, Vinegoni C, Richter D, Yamazoe M, Hulsmans M, Momin N, Grune J, Rohde D, McAlpine CS, Panizzi P, Weissleder R, Kim DE, Swirski FK, Lin CP, Moskowitz MA, Nahrendorf M

Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis.

Nat Neurosci. 2022;25(5):567-576 - PMID: 35501382 - PMCID: PMC9081225 - DOI: 10.1038/s41593-022-01060-2

Schloss MJ, Hulsmans M, Rohde D, Lee IH, Severe N, Foy BH, Pulous FE, Zhang S, Kokkaliaris KD, Frodermann V, Courties G, Yang C, Iwamoto Y, Knudsen AS, McAlpine CS, Yamazoe M, Schmidt SP, Wojtkiewicz GR, Masson GS, Gustafsson K, Capen D, Brown D, Higgins JM, Scadden DT, Libby P, Swirski FK, Naxerova K, Nahrendorf M

B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis.

Nat Immunol. 2022;23(4):605-618 - PMID: 35352063 - PMCID: PMC8989652 - DOI: 10.1038/s41590-022-01165-7

Rohde D, Vandoorne K, Lee IH, Grune J, Zhang S, McAlpine CS, Schloss MJ, Nayar R, Courties G, Frodermann V, Wojtkiewicz G, Honold L, Chen Q, Schmidt S, Iwamoto Y, Sun Y, Cremer S, Hoyer FF, Iborra-Egea O, Muñoz-Guijosa C, Ji F, Zhou B, Adams RH, Wythe JD, Hidalgo J, Watanabe H, Jung Y, van der Laan AM, Piek JJ, Kfoury Y, Désogère PA, Vinegoni C, Dutta P, Sadreyev RI, Caravan P, Bayes-Genis A, Libby P, Scadden DT, Lin CP, Naxerova K, Swirski FK, Nahrendorf M

Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease.

Nat Cardiovasc Res. 2021;1(1):28-44 - PMID: 35747128 - PMCID: PMC9216333 - DOI: 10.1038/s44161-021-00002-8

Bajpai G, Nahrendorf M

Infectious and lifestyle modifiers of immunity and host resilience.

Immunity. 2021;54(6):1110-1122 - PMID: 34107270 - DOI: 10.1016/j.immuni.2021.05.011

Rohde D, Nahrendorf M

Bad company: monocytes in HIV and atherosclerosis.

Cardiovasc Res. 2021;117(4):993-994 - PMID: 33693568 - PMCID: PMC7982997 - DOI: 10.1093/cvr/cvab058

Choi S, Zhang B, Ma S, Gonzalez-Celeiro M, Stein D, Jin X, Kim ST, Kang YL, Besnard A, Rezza A, Grisanti L, Buenrostro JD, Rendl M, Nahrendorf M, Sahay A, Hsu YC

Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence.

Nature. 2021;592(7854):428-432 - PMID: 33790465 - PMCID: PMC8923613 - DOI: 10.1038/s41586-021-03417-2

Nahrendorf M

Response by Nahrendorf to Letter Regarding Article, "Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus".

Circulation. 2021;143(2):e7-e8 - PMID: 33428432 - PMCID: PMC7939058 - DOI: 10.1161/CIRCULATIONAHA.120.051633

Ott C, Pappritz K, Hegemann N, John C, Jeuthe S, McAlpine CS, Iwamoto Y, Lauryn JH, Klages J, Klopfleisch R, Van Linthout S, Swirski F, Nahrendorf M, Kintscher U, Grune T, Kuebler WM, Grune J

Spontaneous Degenerative Aortic Valve Disease in New Zealand Obese Mice.

J Am Heart Assoc. 2021;10(23):e023131 - PMID: 34779224 - PMCID: PMC9075397 - DOI: 10.1161/JAHA.121.023131

Ryu WS, Schellingerhout D, Hong KS, Jeong SW, Kim BJ, Kim JT, Lee KB, Park TH, Park SS, Park JM, Kang K, Cho YJ, Park HK, Lee BC, Yu KH, Oh MS, Lee SJ, Kim JG, Cha JK, Kim DH, Lee J, Han MK, Park MS, Choi KH, Nahrendorf M, Lee J, Bae HJ, Kim DE

Relation of Pre-Stroke Aspirin Use With Cerebral Infarct Volume and Functional Outcomes.

Ann Neurol. 2021;90(5):763-776 - PMID: 34536234 - PMCID: PMC9292882 - DOI: 10.1002/ana.26219

Nahrendorf M

Innate Lymphoid Cells Participate in Myocardial Inflammation After Ischemia.

J Am Coll Cardiol. 2021;78(11):1143-1144 - PMID: 34503683 - DOI: 10.1016/j.jacc.2021.07.013

Barrett TJ, Corr EM, van Solingen C, Schlamp F, Brown EJ, Koelwyn GJ, Lee AH, Shanley LC, Spruill TM, Bozal F, de Jong A, Newman AAC, Drenkova K, Silvestro M, Ramkhelawon B, Reynolds HR, Hochman JS, Nahrendorf M, Swirski FK, Fisher EA, Berger JS, Moore KJ

Chronic stress primes innate immune responses in mice and humans.

Cell Rep. 2021;36(10):109595 - PMID: 34496250 - PMCID: PMC8493594 - DOI: 10.1016/j.celrep.2021.109595

Stiekema LCA, Willemsen L, Kaiser Y, Prange KHM, Wareham NJ, Boekholdt SM, Kuijk C, de Winther MPJ, Voermans C, Nahrendorf M, Stroes ESG, Kroon J

Impact of cholesterol on proinflammatory monocyte production by the bone marrow.

Eur Heart J. 2021;42(42):4309-4320 - PMID: 34343254 - PMCID: PMC8572558 - DOI: 10.1093/eurheartj/ehab465

Hinterdobler J, Schott S, Jin H, Meesmann A, Steinsiek AL, Zimmermann AS, Wobst J, Müller P, Mauersberger C, Vilne B, Baecklund A, Chen CS, Moggio A, Braster Q, Molitor M, Krane M, Kempf WE, Ladwig KH, Hristov M, Hulsmans M, Hilgendorf I, Weber C, Wenzel P, Scheiermann C, Maegdefessel L, Soehnlein O, Libby P, Nahrendorf M, Schunkert H, Kessler T, Sager HB

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.

Eur Heart J. 2021;42(39):4077-4088 - PMID: 34279021 - PMCID: PMC8516477 - DOI: 10.1093/eurheartj/ehab371

McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK

Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.

Nature. 2021;595(7869):701-706 - PMID: 34262178 - PMCID: PMC8934148 - DOI: 10.1038/s41586-021-03734-6

van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Pérez-Medina C, Kluza E, Ye YX, Wojtkiewicz G, Fisher EA, Swirski FK, Nahrendorf M, Zhang B, Li Y, Zhang B, Joosten LAB, Pasterkamp G, Boltjes A, Fayad ZA, Lutgens E, Netea MG, Riksen NP, Mulder WJM, Duivenvoorden R

Prosaposin mediates inflammation in atherosclerosis.

Sci Transl Med. 2021;13(584):ePub - PMID: 33692130 - PMCID: PMC8209679 - DOI: 10.1126/scitranslmed.abe1433

Grune J, Yamazoe M, Nahrendorf M

Electroimmunology and cardiac arrhythmia.

Nat Rev Cardiol. 2021;18(8):547-564 - PMID: 33654273 - PMCID: PMC9703448 - DOI: 10.1038/s41569-021-00520-9

Heyde A, Rohde D, McAlpine CS, Zhang S, Hoyer FF, Gerold JM, Cheek D, Iwamoto Y, Schloss MJ, Vandoorne K, Iborra-Egea O, Muñoz-Guijosa C, Bayes-Genis A, Reiter JG, Craig M, Swirski FK, Nahrendorf M, Nowak MA, Naxerova K

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis.

Cell. 2021;184(5):1348-1361.e22 - PMID: 33636128 - PMCID: PMC8109274 - DOI: 10.1016/j.cell.2021.01.049

Kim J, Jang HJ, Schellingerhout D, Lee SK, Kim H, Kim YD, Lee KY, Choi HY, Cho HJ, Jang SS, Jeon S, Kwon IC, Kim K, Ryu WS, Nahrendorf M, Choi S, Kim DE

Short-Term Cessation of Dabigatran Causes a Paradoxical Prothrombotic State.

Ann Neurol. 2020;89(3):444-458 - PMID: 33219556 - DOI: 10.1002/ana.25964

Panizzi P, Krohn-Grimberghe M, Keliher E, Ye YX, Grune J, Frodermann V, Sun Y, Muse CG, Bushey K, Iwamoto Y, van Leent MMT, Meerwaldt A, Toner YC, Munitz J, Maier A, Soultanidis G, Calcagno C, Pérez-Medina C, Carlucci G, Riddell KP, Barney S, Horne G, Anderson B, Maddur-Appajaiah A, Verhamme IM, Bock PE, Wojtkiewicz GR, Courties G, Swirski FK, Church WR, Walz PH, Tillson DM, Mulder WJM, Nahrendorf M

Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis.

Sci Transl Med. 2020;12(568):ePub - PMID: 33148623 - PMCID: PMC7818516 - DOI: 10.1126/scitranslmed.aay2104

Liu CL, Liu X, Wang Y, Deng Z, Liu T, Sukhova GK, Wojtkiewicz GR, Tang R, Zhang JY, Achilefu S, Nahrendorf M, Libby P, Wang X, Shi GP

Reduced Nhe1 (Na⁺-H⁺ Exchanger-1) Function Protects ApoE-Deficient Mice From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysms.

Hypertension. 2020;76(1):87-100 - PMID: 32475310 - PMCID: PMC7289683 - DOI: 10.1161/HYPERTENSIONAHA.119.14485

Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS

A durable murine model of spleen transplantation with arterial and venous anastomoses.

Sci Rep. 2020;10(1):3979 - PMID: 32132617 - PMCID: PMC7055260 - DOI: 10.1038/s41598-020-60983-7

Xiao L, Salem JE, Clauss S, Hanley A, Bapat A, Hulsmans M, Iwamoto Y, Wojtkiewicz G, Cetinbas M, Schloss MJ, Tedeschi J, Lebrun-Vignes B, Lundby A, Sadreyev RI, Moslehi J, Nahrendorf M, Ellinor PT, Milan DJ

Ibrutinib-Mediated Atrial Fibrillation Attributable to Inhibition of C-Terminal Src Kinase.

Circulation. 2020;142(25):2443-2455 - PMID: 33092403 - PMCID: PMC9661397 - DOI: 10.1161/CIRCULATIONAHA.120.049210

Schloss MJ, Swirski FK, Nahrendorf M

Modifiable Cardiovascular Risk, Hematopoiesis, and Innate Immunity.

Circ Res. 2020;126(9):1242-1259 - PMID: 32324501 - PMCID: PMC7185037 - DOI: 10.1161/CIRCRESAHA.120.315936

Vinegoni C, Fumene Feruglio P, Courties G, Schmidt S, Hulsmans M, Lee S, Wang R, Sosnovik D, Nahrendorf M, Weissleder R

Fluorescence microscopy tensor imaging representations for large-scale dataset analysis.

Sci Rep. 2020;10(1):5632 - PMID: 32221334 - PMCID: PMC7101442 - DOI: 10.1038/s41598-020-62233-2

Nahrendorf M, Hoyer FF, Meerwaldt AE, van Leent MMT, Senders ML, Calcagno C, Robson PM, Soultanidis G, Pérez-Medina C, Teunissen AJP, Toner YC, Ishikawa K, Fish K, Sakurai K, van Leeuwen EM, Klein ED, Sofias AM, Reiner T, Rohde D, Aguirre AD, Wojtkiewicz G, Schmidt S, Iwamoto Y, Izquierdo-Garcia D, Caravan P, Swirski FK, Weissleder R, Mulder WJM

Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor ⁶⁴Cu-Macrin in Mice, Rabbits, and Pigs.

Circ Cardiovasc Imaging. 2020;13(10):e010586 - PMID: 33076700 - PMCID: PMC7583675 - DOI: 10.1161/CIRCIMAGING.120.010586

Krohn-Grimberghe M, Mitchell MJ, Schloss MJ, Khan OF, Courties G, Guimaraes PPG, Rohde D, Cremer S, Kowalski PS, Sun Y, Tan M, Webster J, Wang K, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Nayar R, Frodermann V, Hulsmans M, Chung A, Hoyer FF, Swirski FK, Langer R, Anderson DG, Nahrendorf M

Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche.

Nat Biomed Eng. 2020;4(11):1076-1089 - PMID: 33020600 - PMCID: PMC7655681 - DOI: 10.1038/s41551-020-00623-7

Chan CT, Fenn AM, Harder NK, Mindur JE, McAlpine CS, Patel J, Valet C, Rattik S, Iwamoto Y, He S, Anzai A, Kahles F, Poller WC, Janssen H, Wong LP, Fernandez-Hernando C, Koolbergen DR, van der Laan AM, Yvan-Charvet L, Sadreyev RI, Nahrendorf M, Westerterp M, Tall AR, Gustafsson JA, Swirski FK

Liver X receptors are required for thymic resilience and T cell output.

J Exp Med. 2020;217(10):ePub - PMID: 32716519 - PMCID: PMC7537384 - DOI: 10.1084/jem.20200318

Hoyer FF, Zhang X, Coppin E, Vasamsetti SB, Modugu G, Schloss MJ, Rohde D, McAlpine CS, Iwamoto Y, Libby P, Naxerova K, Swirski FK, Dutta P, Nahrendorf M

Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus.

Circulation. 2020;142(3):244-258 - PMID: 32316750 - PMCID: PMC7375017 - DOI: 10.1161/CIRCULATIONAHA.120.046038

Senders ML, Meerwaldt AE, van Leent MMT, Sanchez-Gaytan BL, van de Voort JC, Toner YC, Maier A, Klein ED, Sullivan NAT, Sofias AM, Groenen H, Faries C, Oosterwijk RS, van Leeuwen EM, Fay F, Chepurko E, Reiner T, Duivenvoorden R, Zangi L, Dijkhuizen RM, Hak S, Swirski FK, Nahrendorf M, Pérez-Medina C, Teunissen AJP, Fayad ZA, Calcagno C, Strijkers GJ, Mulder WJM

Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging.

Nat Nanotechnol. 2020;15(5):398-405 - PMID: 32313216 - PMCID: PMC7416336 - DOI: 10.1038/s41565-020-0642-4

Poller WC, Nahrendorf M, Swirski FK

Hematopoiesis and Cardiovascular Disease.

Circ Res. 2020;126(8):1061-1085 - PMID: 32271679 - PMCID: PMC7153537 - DOI: 10.1161/CIRCRESAHA.120.315895

Hadjikhani N, Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Nahrendorf M, Loggia ML, Moskowitz MA

Extra-Axial Inflammatory Signal in Parameninges in Migraine with Visual Aura.

Ann Neurol. 2020;87(6):939-949 - PMID: 32239542 - PMCID: PMC7313427 - DOI: 10.1002/ana.25731

Nahrendorf M, Abbate A, Narula J

Correction to: Deciphering post-infarct inflammation: Should it heal, would it hurt?

J Nucl Cardiol. 2020;27(4):1384 - PMID: 32140993 - DOI: 10.1007/s12350-020-02090-8

Leuschner F, Nahrendorf M

Novel functions of macrophages in the heart: insights into electrical conduction, stress, and diastolic dysfunction.

Eur Heart J. 2020;41(9):989-994 - PMID: 30945736 - PMCID: PMC7778432 - DOI: 10.1093/eurheartj/ehz159

Cremer S, Schloss MJ, Vinegoni C, Foy BH, Zhang S, Rohde D, Hulsmans M, Fumene Feruglio P, Schmidt S, Wojtkiewicz G, Higgins JM, Weissleder R, Swirski FK, Nahrendorf M

Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction.

J Am Coll Cardiol. 2020;75(8):901-915 - PMID: 32130926 - PMCID: PMC7254576 - DOI: 10.1016/j.jacc.2019.12.056

Nahrendorf M, Abbate A, Narula J

Deciphering post-infarct inflammation: Should it heal, would it hurt?

J Nucl Cardiol. 2020;27(6):2100-2102 - PMID: 32086743 - DOI: 10.1007/s12350-020-02053-z

Hulsmans M, Nahrendorf M

Proliferative, degradative smooth muscle cells promote aortic disease.

J Clin Invest. 2020;130(3):1096-1098 - PMID: 32039919 - PMCID: PMC7269557 - DOI: 10.1172/JCI134019

Duivenvoorden R, Senders ML, van Leent MMT, Pérez-Medina C, Nahrendorf M, Fayad ZA, Mulder WJM

Nanoimmunotherapy to treat ischaemic heart disease.

Nat Rev Cardiol. 2019;16(1):21-32 - PMID: 30209355 - PMCID: PMC10621601 - DOI: 10.1038/s41569-018-0073-1

Libby P, Swirski FK, Nahrendorf M

The Myocardium: More Than Myocytes.

J Am Coll Cardiol. 2019;74(25):3136-3138 - PMID: 31856970 - DOI: 10.1016/j.jacc.2019.10.031

Binderup T, Duivenvoorden R, Fay F, van Leent MMT, Malkus J, Baxter S, Ishino S, Zhao Y, Sanchez-Gaytan B, Teunissen AJP, Frederico YCA, Tang J, Carlucci G, Lyashchenko S, Calcagno C, Karakatsanis N, Soultanidis G, Senders ML, Robson PM, Mani V, Ramachandran S, Lobatto ME, Hutten BA, Granada JF, Reiner T, Swirski FK, Nahrendorf M, Kjaer A, Fisher EA, Fayad ZA, Pérez-Medina C, Mulder WJM

Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species.

Sci Transl Med. 2019;11(506):ePub - PMID: 31434756 - PMCID: PMC7328283 - DOI: 10.1126/scitranslmed.aaw7736

Severe N, Karabacak NM, Gustafsson K, Baryawno N, Courties G, Kfoury Y, Kokkaliaris KD, Rhee C, Lee D, Scadden EW, Garcia-Robledo JE, Brouse T, Nahrendorf M, Toner M, Scadden DT

Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping.

Cell Stem Cell. 2019;25(4):570-583.e7 - PMID: 31279774 - PMCID: PMC6778015 - DOI: 10.1016/j.stem.2019.06.003

Hoyer FF, Nahrendorf M

Interferon-γ regulates cardiac myeloid cells in myocardial infarction.

Cardiovasc Res. 2019;115(13):1815-1816 - PMID: 31161218 - PMCID: PMC6803813 - DOI: 10.1093/cvr/cvz143

Courties G, Frodermann V, Honold L, Zheng Y, Herisson F, Schloss MJ, Sun Y, Presumey J, Severe N, Engblom C, Hulsmans M, Cremer S, Rohde D, Pittet MJ, Scadden DT, Swirski FK, Kim DE, Moskowitz MA, Nahrendorf M

Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke.

Circ Res. 2019;124(9):1372-1385 - PMID: 30782088 - PMCID: PMC6483874 - DOI: 10.1161/CIRCRESAHA.118.314518

Swirski FK, Nahrendorf M

Reply to 'Cardioimmunology of arrhythmias: the role of autoimmune and inflammatory cardiac channelopathies'.

Nat Rev Immunol. 2019;19(1):65 - PMID: 30552386 - DOI: 10.1038/s41577-018-0099-y

Kim J, Lee SK, Schellingerhout D, Nahrendorf M, Kim K, Kim J, Kim DE

Spectroscopic Assessment of Gold Nanoparticle Biodistribution Using Surface Plasmon Resonance Phenomena.

ACS Biomater Sci Eng. 2019;5(12):6389-6394 - PMID: 33417791 - DOI: 10.1021/acsbiomaterials.9b01079

Vagnozzi RJ, Maillet M, Sargent MA, Khalil H, Johansen AKZ, Schwanekamp JA, York AJ, Huang V, Nahrendorf M, Sadayappan S, Molkentin JD

An acute immune response underlies the benefit of cardiac stem cell therapy.

Nature. 2019;577(7790):405-409 - PMID: 31775156 - PMCID: PMC6962570 - DOI: 10.1038/s41586-019-1802-2

Hoyer FF, Naxerova K, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M

Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.

Immunity. 2019;51(5):899-914.e7 - PMID: 31732166 - PMCID: PMC6892583 - DOI: 10.1016/j.immuni.2019.10.010

Kalman JM, Lavandero S, Mahfoud F, Nahrendorf M, Yacoub MH, Zhao D

Looking back and thinking forwards - 15 years of cardiology and cardiovascular research.

Nat Rev Cardiol. 2019;16(11):651-660 - PMID: 31570832 - DOI: 10.1038/s41569-019-0261-7

Liu CL, Zhang X, Liu J, Wang Y, Sukhova GK, Wojtkiewicz GR, Liu T, Tang R, Achilefu S, Nahrendorf M, Libby P, Guo J, Zhang JY, Shi GP

Na⁺-H⁺ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis.

Nat Commun. 2019;10(1):3978 - PMID: 31484936 - PMCID: PMC6726618 - DOI: 10.1038/s41467-019-11983-3

Tawakol A, Osborne MT, Wang Y, Hammed B, Tung B, Patrich T, Oberfeld B, Ishai A, Shin LM, Nahrendorf M, Warner ET, Wasfy J, Fayad ZA, Koenen K, Ridker PM, Pitman RK, Armstrong KA

Stress-Associated Neurobiological Pathway Linking Socioeconomic Disparities to Cardiovascular Disease.

J Am Coll Cardiol. 2019;73(25):3243-3255 - PMID: 31248544 - PMCID: PMC6767929 - DOI: 10.1016/j.jacc.2019.04.042

Hulsmans M, Nahrendorf M

Smad3 Cranks Up the Appetite of Infarct Macrophages.

Circ Res. 2019;125(1):71-73 - PMID: 31219739 - PMCID: PMC6588180 - DOI: 10.1161/CIRCRESAHA.119.315306

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Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair.

J Am Coll Cardiol. 2019;73(23):2990-3002 - PMID: 31196457 - DOI: 10.1016/j.jacc.2019.03.503

Rohde D, Nahrendorf M

Clonal and diverse: revisiting cardiac endothelial cells after myocardial infarction.

Eur Heart J. 2019;40(30):2521-2522 - PMID: 31162523 - PMCID: PMC6685322 - DOI: 10.1093/eurheartj/ehz375

Wang C, Keliher E, Zeller MWG, Wojtkiewicz GR, Aguirre AD, Buckbinder L, Kim HY, Chen J, Maresca K, Ahmed MS, Motlagh NJ, Nahrendorf M, Chen JW

An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.

Proc Natl Acad Sci U S A. 2019;116(24):11966-11971 - PMID: 31123149 - PMCID: PMC6575581 - DOI: 10.1073/pnas.1818434116

Ahmed MS, Rodell CB, Hulsmans M, Kohler RH, Aguirre AD, Nahrendorf M, Weissleder R

A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart.

Bioconjug Chem. 2019;30(3):733-740 - PMID: 30615425 - PMCID: PMC6483069 - DOI: 10.1021/acs.bioconjchem.8b00882

Hoyer FF, Nahrendorf M

Uremic Toxins Activate Macrophages.

Circulation. 2019;139(1):97-100 - PMID: 30592654 - PMCID: PMC6394415 - DOI: 10.1161/CIRCULATIONAHA.118.037308

Frodermann V, Rohde D, Courties G, Severe N, Schloss MJ, Amatullah H, McAlpine CS, Cremer S, Hoyer FF, Ji F, van Koeverden ID, Herisson F, Honold L, Masson GS, Zhang S, Grune J, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Lee IH, Gustafsson K, Pasterkamp G, de Jager SCA, Sadreyev RI, MacFadyen J, Libby P, Ridker P, Scadden DT, Naxerova K, Jeffrey KL, Swirski FK, Nahrendorf M

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells.

Nat Med. 2019;25(11):1761-1771 - PMID: 31700184 - PMCID: PMC6858591 - DOI: 10.1038/s41591-019-0633-x

He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.

Nature. 2019;566(7742):115-119 - PMID: 30700910 - PMCID: PMC6367023 - DOI: 10.1038/s41586-018-0849-9

Vromman A, Ruvkun V, Shvartz E, Wojtkiewicz G, Santos Masson G, Tesmenitsky Y, Folco E, Gram H, Nahrendorf M, Swirski FK, Sukhova GK, Libby P

Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis.

Eur Heart J. 2019;40(30):2482-2491 - PMID: 30698710 - PMCID: PMC6685323 - DOI: 10.1093/eurheartj/ehz008

Anzai A, Mindur JE, Halle L, Sano S, Choi JL, He S, McAlpine CS, Chan CT, Kahles F, Valet C, Fenn AM, Nairz M, Rattik S, Iwamoto Y, Fairweather D, Walsh K, Libby P, Nahrendorf M, Swirski FK

Self-reactive CD4⁺ IL-3⁺ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis.

J Exp Med. 2019;216(2):369-383 - PMID: 30670465 - PMCID: PMC6363430 - DOI: 10.1084/jem.20180722

McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L, Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M, Swirski FK

Sleep modulates haematopoiesis and protects against atherosclerosis.

Nature. 2019;566(7744):383-387 - PMID: 30760925 - PMCID: PMC6442744 - DOI: 10.1038/s41586-019-0948-2

Nahrendorf M

Multiorgan Imaging of Comorbidity and Cardiovascular Risk.

JACC Cardiovasc Imaging. 2018;13(2 Pt 1):478-480 - PMID: 30448129 - DOI: 10.1016/j.jcmg.2018.09.017

Verweij SL, Duivenvoorden R, Stiekema LCA, Nurmohamed NS, van der Valk FM, Versloot M, Verberne HJ, Stroes ESG, Nahrendorf M, Bekkering S, Bernelot Moens SJ

CCR2 expression on circulating monocytes is associated with arterial wall inflammation assessed by 18F-FDG PET/CT in patients at risk for cardiovascular disease.

Cardiovasc Res. 2018;114(3):468-475 - PMID: 29186373 - DOI: 10.1093/cvr/cvx224

Vandoorne K, Rohde D, Kim HY, Courties G, Wojtkiewicz G, Honold L, Hoyer FF, Frodermann V, Nayar R, Herisson F, Jung Y, Désogère PA, Vinegoni C, Caravan P, Weissleder R, Sosnovik DE, Lin CP, Swirski FK, Nahrendorf M

Imaging the Vascular Bone Marrow Niche During Inflammatory Stress.

Circ Res. 2018;123(4):415-427 - PMID: 29980569 - PMCID: PMC6202141 - DOI: 10.1161/CIRCRESAHA.118.313302

Swirski FK, Nahrendorf M

Clonal Hematopoiesis Wages War on the Myocardium.

J Am Coll Cardiol. 2018;71(8):887-889 - PMID: 29471940 - DOI: 10.1016/j.jacc.2017.12.038

Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J

Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.

Immunity. 2018;49(5):819-828.e6 - PMID: 30413362 - PMCID: PMC6251711 - DOI: 10.1016/j.immuni.2018.09.008

Frodermann V, Nahrendorf M

Macrophages and Cardiovascular Health.

Physiol Rev. 2018;98(4):2523-2569 - PMID: 30156496 - PMCID: PMC6442921 - DOI: 10.1152/physrev.00068.2017

Bajpai G, Schneider C, Wong N, Bredemeyer A, Hulsmans M, Nahrendorf M, Epelman S, Kreisel D, Liu Y, Itoh A, Shankar TS, Selzman CH, Drakos SG, Lavine KJ

The human heart contains distinct macrophage subsets with divergent origins and functions.

Nat Med. 2018;24(8):1234-1245 - PMID: 29892064 - PMCID: PMC6082687 - DOI: 10.1038/s41591-018-0059-x

Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M

Cardiac macrophages promote diastolic dysfunction.

J Exp Med. 2018;215(2):423-440 - PMID: 29339450 - PMCID: PMC5789416 - DOI: 10.1084/jem.20171274

Nahrendorf M

Myeloid cells in cardiovascular organs.

J Intern Med. 2018;285(5):491-502 - PMID: 30585362 - PMCID: PMC6497541 - DOI: 10.1111/joim.12844

Nahrendorf M, Vandoorne K

Albumin-Binding MR Probe Detects High-Risk Coronary Plaques in Patients.

JACC Cardiovasc Imaging. 2018;12(2):307-309 - PMID: 29361477 - DOI: 10.1016/j.jcmg.2017.11.026

Hoogeveen RM, Nahrendorf M, Riksen NP, Netea MG, de Winther MPJ, Lutgens E, Nordestgaard BG, Neidhart M, Stroes ESG, Catapano AL, Bekkering S

Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases.

Eur Heart J. 2018;39(38):3521-3527 - PMID: 29069365 - PMCID: PMC6174026 - DOI: 10.1093/eurheartj/ehx581

Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Pérez-Medina C, Calcagno C, Fisher EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R

Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates.

Nat Biomed Eng. 2018;2(5):279-292 - PMID: 30936448 - PMCID: PMC6447057 - DOI: 10.1038/s41551-018-0221-2

Hsue PY, Li D, Ma Y, Ishai A, Manion M, Nahrendorf M, Ganz P, Ridker PM, Deeks SG, Tawakol A

IL-1β Inhibition Reduces Atherosclerotic Inflammation in HIV Infection.

J Am Coll Cardiol. 2018;72(22):2809-2811 - PMID: 30497570 - PMCID: PMC8723182 - DOI: 10.1016/j.jacc.2018.09.038

Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet MJ, Nahrendorf M, Weissleder R, Miller MA

Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using ⁶⁴Cu-Labeled Macrin.

ACS Nano. 2018;12(12):12015-12029 - PMID: 30508377 - PMCID: PMC6482841 - DOI: 10.1021/acsnano.8b04338

Hulsmans M, Aguirre AD, Bonner MD, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M

A Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse.

Circ Res. 2018;123(11):1208-1219 - PMID: 30571465 - PMCID: PMC6309285 - DOI: 10.1161/CIRCRESAHA.118.313429

Schloss MJ, Nahrendorf M

Some Macrophages Are Softies.

Immunity. 2018;49(2):199-201 - PMID: 30134196 - DOI: 10.1016/j.immuni.2018.08.007

Cremer S, Nahrendorf M

Myeloid Cells Remodel the Mitral Valve.

Circulation. 2018;137(23):2494-2496 - PMID: 29866774 - PMCID: PMC5992497 - DOI: 10.1161/CIRCULATIONAHA.118.033622

Brannen A, Eggert M, Nahrendorf M, Arnold R, Panizzi P

Correlation of 360-degree Surface Mapping In Vivo Bioluminescence with Multi-Spectral Optoacoustic Tomography in Human Xenograft Tumor Models.

Sci Rep. 2018;8(1):3321 - PMID: 29463820 - PMCID: PMC5820276 - DOI: 10.1038/s41598-018-21668-4

Ryu WS, Bae EK, Park SH, Jeong SW, Schellingerhout D, Nahrendorf M, Kim DE

Increased Left Ventricular Filling Pressure and Arterial Occlusion in Stroke Related to Atrial Fibrillation.

J Stroke Cerebrovasc Dis. 2018;27(5):1275-1282 - PMID: 29310958 - DOI: 10.1016/j.jstrokecerebrovasdis.2017.12.009

Honold L, Nahrendorf M

Resident and Monocyte-Derived Macrophages in Cardiovascular Disease.

Circ Res. 2018;122(1):113-127 - PMID: 29301844 - PMCID: PMC5777215 - DOI: 10.1161/CIRCRESAHA.117.311071

Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Masson GS, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration.

Nat Neurosci. 2018;21(9):1209-1217 - PMID: 30150661 - PMCID: PMC6148759 - DOI: 10.1038/s41593-018-0213-2

Nahrendorf M

Myeloid cell contributions to cardiovascular health and disease.

Nat Med. 2018;24(6):711-720 - PMID: 29867229 - PMCID: PMC7301893 - DOI: 10.1038/s41591-018-0064-0

Swirski FK, Nahrendorf M

Cardioimmunology: the immune system in cardiac homeostasis and disease.

Nat Rev Immunol. 2018;18(12):733-744 - PMID: 30228378 - DOI: 10.1038/s41577-018-0065-8

Franck G, Mawson T, Sausen G, Salinas M, Masson GS, Cole A, Beltrami-Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce KJ, Libby P

Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion.

Circ Res. 2017;121(1):31-42 - PMID: 28428204 - PMCID: PMC5488735 - DOI: 10.1161/CIRCRESAHA.117.310694

Swirski FK, Nahrendorf M

Inflammation: Old, caffeinated, and healthy.

Nat Rev Cardiol. 2017;14(4):194-196 - PMID: 28250451 - DOI: 10.1038/nrcardio.2017.22

van der Valk FM, Kuijk C, Verweij SL, Stiekema LCA, Kaiser Y, Zeerleder S, Nahrendorf M, Voermans C, Stroes ESG

Increased haematopoietic activity in patients with atherosclerosis.

Eur Heart J. 2017;38(6):425-432 - PMID: 27357356 - DOI: 10.1093/eurheartj/ehw246

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Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF^high neutrophils.

Science. 2017;358(6367):ePub - PMID: 29191879 - PMCID: PMC6343476 - DOI: 10.1126/science.aal5081

Shon SM, Jang HJ, Schellingerhout D, Kim JY, Ryu WS, Lee SK, Kim J, Park JY, Oh JH, Kang JW, Je KH, Park JE, Kim K, Kwon IC, Lee J, Nahrendorf M, Park JH, Kim DE

Cytokine Response to Diet and Exercise Affects Atheromatous Matrix Metalloproteinase-2/9 Activity in Mice.

Circ J. 2017;81(10):1528-1536 - PMID: 28883215 - DOI: 10.1253/circj.CJ-16-1196

Meyer IS, Jungmann A, Dieterich C, Zhang M, Lasitschka F, Werkmeister S, Haas J, Müller OJ, Boutros M, Nahrendorf M, Katus HA, Hardt SE, Leuschner F

The cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction.

EMBO Mol Med. 2017;9(9):1279-1293 - PMID: 28774883 - PMCID: PMC5582413 - DOI: 10.15252/emmm.201707565

Alaarg A, Pérez-Medina C, Metselaar JM, Nahrendorf M, Fayad ZA, Storm G, Mulder WJM

Applying nanomedicine in maladaptive inflammation and angiogenesis.

Adv Drug Deliv Rev. 2017;119:143-158 - PMID: 28506745 - PMCID: PMC5682240 - DOI: 10.1016/j.addr.2017.05.009

Pérez-Medina C, Hak S, Reiner T, Fayad ZA, Nahrendorf M, Mulder WJM

Integrating nanomedicine and imaging.

Philos Trans A Math Phys Eng Sci. 2017;375(2107):ePub - PMID: 29038380 - PMCID: PMC5647268 - DOI: 10.1098/rsta.2017.0110

Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.

J Exp Med. 2017;214(11):3293-3310 - PMID: 28978634 - PMCID: PMC5679174 - DOI: 10.1084/jem.20170689

Teague HL, Ahlman MA, Alavi A, Wagner DD, Lichtman AH, Nahrendorf M, Swirski FK, Nestle F, Gelfand JM, Kaplan MJ, Grinspoon S, Ridker PM, Newby DE, Tawakol A, Fayad ZA, Mehta NN

Unraveling Vascular Inflammation: From Immunology to Imaging.

J Am Coll Cardiol. 2017;70(11):1403-1412 - PMID: 28882238 - PMCID: PMC5658004 - DOI: 10.1016/j.jacc.2017.07.750

Stiekema LCA, Schnitzler JG, Nahrendorf M, Stroes ESG

The maturation of a 'neural-hematopoietic' inflammatory axis in cardiovascular disease.

Curr Opin Lipidol. 2017;28(6):507-512 - PMID: 28877089 - DOI: 10.1097/MOL.0000000000000457

Kim DE, Kim JY, Schellingerhout D, Ryu JH, Lee SK, Jeon S, Lee JS, Kim J, Jang HJ, Park JE, Kim EJ, Kwon IC, Ahn CH, Nahrendorf M, Kim K

Quantitative Imaging of Cerebral Thromboemboli In Vivo: The Effects of Tissue-Type Plasminogen Activator.

Stroke. 2017;48(5):1376-1385 - PMID: 28432262 - DOI: 10.1161/STROKEAHA.117.016511

Vandoorne K, Nahrendorf M

Multiparametric Imaging of Organ System Interfaces.

Circ Cardiovasc Imaging. 2017;10(4):ePub - PMID: 28360260 - PMCID: PMC5419074 - DOI: 10.1161/CIRCIMAGING.116.005613

Hoyer FF, Nahrendorf M

Neutrophil contributions to ischaemic heart disease.

Eur Heart J. 2017;38(7):465-472 - PMID: 28363210 - DOI: 10.1093/eurheartj/ehx017

Nahrendorf M, Swirski FK

Cholesterol, CCR2, and monocyte phenotypes in atherosclerosis.

Eur Heart J. 2017;38(20):1594-1596 - PMID: 28329093 - DOI: 10.1093/eurheartj/ehx098

Lee S, Courties G, Nahrendorf M, Weissleder R, Vinegoni C

Motion characterization scheme to minimize motion artifacts in intravital microscopy.

J Biomed Opt. 2017;22(3):36005 - PMID: 28253383 - PMCID: PMC5333764 - DOI: 10.1117/1.JBO.22.3.036005

Frodermann V, Nahrendorf M

Neutrophil-macrophage cross-talk in acute myocardial infarction.

Eur Heart J. 2017;38(3):198-200 - PMID: 28158564 - PMCID: PMC5837392 - DOI: 10.1093/eurheartj/ehw085

Je KH, Ryu WS, Lee SK, Kim EJ, Kim JY, Jang HJ, Park JE, Nahrendorf M, Schellingerhout D, Kim DE

Green-channel autofluorescence imaging: A novel and sensitive technique to delineate infarcts.

J Neurosci Methods. 2017;279:22-32 - PMID: 28104485 - DOI: 10.1016/j.jneumeth.2017.01.007

Tawakol A, Ishai A, Takx RA, Figueroa AL, Ali A, Kaiser Y, Truong QA, Solomon CJ, Calcagno C, Mani V, Tang CY, Mulder WJ, Murrough JW, Hoffmann U, Nahrendorf M, Shin LM, Fayad ZA, Pitman RK

Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study.

Lancet. 2017;389(10071):834-845 - PMID: 28088338 - PMCID: PMC7864285 - DOI: 10.1016/S0140-6736(16)31714-7

Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M

Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.

Nat Commun. 2017;8:14064 - PMID: 28091604 - PMCID: PMC5241815 - DOI: 10.1038/ncomms14064

King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R

IRF3 and type I interferons fuel a fatal response to myocardial infarction.

Nat Med. 2017;23(12):1481-1487 - PMID: 29106401 - PMCID: PMC6477926 - DOI: 10.1038/nm.4428

Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M

Macrophages Facilitate Electrical Conduction in the Heart.

Cell. 2017;169(3):510-522.e20 - PMID: 28431249 - PMCID: PMC5474950 - DOI: 10.1016/j.cell.2017.03.050

Libby P, Nahrendorf M, Swirski FK

Reply: The Networks Between the Sympathetic Nervous System and Immune System in Atherosclerosis.

J Am Coll Cardiol. 2016;68(4):432 - PMID: 27443446 - DOI: 10.1016/j.jacc.2016.05.017

Sager HB, Nahrendorf M

Inflammation: a trigger for acute coronary syndrome.

Q J Nucl Med Mol Imaging. 2016;60(3):185-93 - PMID: 27273431

Pinciroli R, Mietto C, Piriyapatsom A, Chenelle CT, Thomas JG, Pirrone M, Bry L, Wojtkiewicz GR, Nahrendorf MP, Kacmarek RM, Berra L

Endotracheal Tubes Cleaned With a Novel Mechanism for Secretion Removal: A Randomized Controlled Clinical Study.

Respir Care. 2016;61(11):1431-1439 - PMID: 27460104 - DOI: 10.4187/respcare.04363

Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.

Nat Med. 2016;22(8):945-51 - PMID: 27428900 - PMCID: PMC4957133 - DOI: 10.1038/nm.4146

Ryu WS, Schellingerhout D, Jeong SW, Nahrendorf M, Kim DE

Association between Serum Lipid Profiles and Early Neurological Deterioration in Acute Ischemic Stroke.

J Stroke Cerebrovasc Dis. 2016;25(8):2024-30 - PMID: 27256172 - DOI: 10.1016/j.jstrokecerebrovasdis.2016.05.009

Libby P, Nahrendorf M, Swirski FK

Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum".

J Am Coll Cardiol. 2016;67(9):1091-1103 - PMID: 26940931 - PMCID: PMC4779182 - DOI: 10.1016/j.jacc.2015.12.048

Calcagno C, Mulder WJ, Nahrendorf M, Fayad ZA

Systems Biology and Noninvasive Imaging of Atherosclerosis.

Arterioscler Thromb Vasc Biol. 2016;36(2):e1-8 - PMID: 26819466 - PMCID: PMC4861402 - DOI: 10.1161/ATVBAHA.115.306350

Ali M, Pulli B, Courties G, Tricot B, Sebas M, Iwamoto Y, Hilgendorf I, Schob S, Dong A, Zheng W, Skoura A, Kalgukar A, Cortes C, Ruggeri R, Swirski FK, Nahrendorf M, Buckbinder L, Chen JW

Myeloperoxidase Inhibition Improves Ventricular Function and Remodeling After Experimental Myocardial Infarction.

JACC Basic Transl Sci. 2016;1(7):633-643 - PMID: 30167547 - PMCID: PMC6113523 - DOI: 10.1016/j.jacbts.2016.09.004

Tang J, Baxter S, Menon A, Alaarg A, Sanchez-Gaytan BL, Fay F, Zhao Y, Ouimet M, Braza MS, Longo VA, Abdel-Atti D, Duivenvoorden R, Calcagno C, Storm G, Tsimikas S, Moore KJ, Swirski FK, Nahrendorf M, Fisher EA, Pérez-Medina C, Fayad ZA, Reiner T, Mulder WJ

Immune cell screening of a nanoparticle library improves atherosclerosis therapy.

Proc Natl Acad Sci U S A. 2016;113(44):E6731-E6740 - PMID: 27791119 - PMCID: PMC5098679 - DOI: 10.1073/pnas.1609629113

Kim J, Park JE, Nahrendorf M, Kim DE

Direct Thrombus Imaging in Stroke.

J Stroke. 2016;18(3):286-296 - PMID: 27733029 - PMCID: PMC5066439 - DOI: 10.5853/jos.2016.00906

Swirski FK, Nahrendorf M, Libby P

Mechanisms of Myeloid Cell Modulation of Atherosclerosis.

Microbiol Spectr. 2016;4(4):ePub - PMID: 27726819 - DOI: 10.1128/microbiolspec.MCHD-0026-2015

Swirski FK, Nahrendorf M

Bone Marrow Takes Center Stage in Cardiovascular Disease.

Circ Res. 2016;119(6):701-3 - PMID: 27587406 - PMCID: PMC5012290 - DOI: 10.1161/CIRCRESAHA.116.309584

Dutta P, Hoyer FF, Sun Y, Iwamoto Y, Tricot B, Weissleder R, Magnani JL, Swirski FK, Nahrendorf M

E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction.

Arterioscler Thromb Vasc Biol. 2016;36(9):1802-8 - PMID: 27470513 - PMCID: PMC5001901 - DOI: 10.1161/ATVBAHA.116.307519

Nahrendorf M, Swirski FK

Abandoning M1/M2 for a Network Model of Macrophage Function.

Circ Res. 2016;119(3):414-7 - PMID: 27458196 - PMCID: PMC4965179 - DOI: 10.1161/CIRCRESAHA.116.309194

Sager HB, Hulsmans M, Lavine KJ, Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.

Circ Res. 2016;119(7):853-64 - PMID: 27444755 - PMCID: PMC5378496 - DOI: 10.1161/CIRCRESAHA.116.309001

Rischpler C, Dirschinger RJ, Nekolla SG, Kossmann H, Nicolosi S, Hanus F, van Marwick S, Kunze KP, Meinicke A, Götze K, Kastrati A, Langwieser N, Ibrahim T, Nahrendorf M, Schwaiger M, Laugwitz KL

Prospective Evaluation of 18F-Fluorodeoxyglucose Uptake in Postischemic Myocardium by Simultaneous Positron Emission Tomography/Magnetic Resonance Imaging as a Prognostic Marker of Functional Outcome.

Circ Cardiovasc Imaging. 2016;9(4):e004316 - PMID: 27056601 - PMCID: PMC4826716 - DOI: 10.1161/CIRCIMAGING.115.004316

Davis RW, Brannen AD, Hossain MJ, Monsma S, Bock PE, Nahrendorf M, Mead D, Lodes M, Liles MR, Panizzi P

Complete genome of Staphylococcus aureus Tager 104 provides evidence of its relation to modern systemic hospital-acquired strains.

BMC Genomics. 2016;17:179 - PMID: 26940863 - PMCID: PMC4778325 - DOI: 10.1186/s12864-016-2433-8

Swirski FK, Robbins CS, Nahrendorf M

Development and Function of Arterial and Cardiac Macrophages.

Trends Immunol. 2016;37(1):32-40 - PMID: 26748179 - PMCID: PMC4706986 - DOI: 10.1016/j.it.2015.11.004

Valero-Muñoz M, Li S, Wilson RM, Hulsmans M, Aprahamian T, Fuster JJ, Nahrendorf M, Scherer PE, Sam F

Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue.

Circ Heart Fail. 2016;9(1):e002724 - PMID: 26721917 - PMCID: PMC4698901 - DOI: 10.1161/CIRCHEARTFAILURE.115.002724

Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction.

Sci Transl Med. 2016;8(342):342ra80 - PMID: 27280687 - PMCID: PMC5125383 - DOI: 10.1126/scitranslmed.aaf1435

Nahrendorf M, Swirski FK

Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction?

Eur Heart J. 2015;37(11):868-72 - PMID: 26351395 - PMCID: PMC4789592 - DOI: 10.1093/eurheartj/ehv453

Nahrendorf M, Swirski FK

PET Imaging of Leukocytes in Patients With Acute Myocardial Infarction.

JACC Cardiovasc Imaging. 2015;8(12):1427-1429 - PMID: 26699111 - DOI: 10.1016/j.jcmg.2015.10.004

Signore S, Sorrentino A, Borghetti G, Cannata A, Meo M, Zhou Y, Kannappan R, Pasqualini F, O'Malley H, Sundman M, Tsigkas N, Zhang E, Arranto C, Mangiaracina C, Isobe K, Sena BF, Kim J, Goichberg P, Nahrendorf M, Isom LL, Leri A, Anversa P, Rota M

Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy.

Nat Commun. 2015;6:8803 - PMID: 26541940 - PMCID: PMC4638135 - DOI: 10.1038/ncomms9803

Joseph P, Ishai A, MacNabb M, Abdelbaky A, Lavender ZR, Ruskin J, Nahrendorf M, Tawakol A

Atrial fibrillation is associated with hematopoietic tissue activation and arterial inflammation.

Int J Cardiovasc Imaging. 2015;32(1):113-9 - PMID: 26411879 - PMCID: PMC4730873 - DOI: 10.1007/s10554-015-0766-z

Ye YX, Calcagno C, Binderup T, Courties G, Keliher EJ, Wojtkiewicz GR, Iwamoto Y, Tang J, Pérez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjaer A, Mulder WJ, Nahrendorf M

Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis.

Circ Res. 2015;117(10):835-45 - PMID: 26394773 - PMCID: PMC4619168 - DOI: 10.1161/CIRCRESAHA.115.307024

Tang J, Lobatto ME, Hassing L, van der Staay S, van Rijs SM, Calcagno C, Braza MS, Baxter S, Fay F, Sanchez-Gaytan BL, Duivenvoorden R, Sager H, Astudillo YM, Leong W, Ramachandran S, Storm G, Pérez-Medina C, Reiner T, Cormode DP, Strijkers GJ, Stroes ES, Swirski FK, Nahrendorf M, Fisher EA, Fayad ZA, Mulder WJ

Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation.

Sci Adv. 2015;1(3):ePub - PMID: 26295063 - PMCID: PMC4539616 - DOI: 10.1126/sciadv.1400223

Nahrendorf M, Swirski FK

Immunology. Neutrophil-macrophage communication in inflammation and atherosclerosis.

Science. 2015;349(6245):237-8 - PMID: 26185231 - DOI: 10.1126/science.aac7801

Nahrendorf M, Frantz S, Swirski FK, Mulder WJ, Randolph G, Ertl G, Ntziachristos V, Piek JJ, Stroes ES, Schwaiger M, Mann DL, Fayad ZA

Imaging systemic inflammatory networks in ischemic heart disease.

J Am Coll Cardiol. 2015;65(15):1583-91 - PMID: 25881940 - PMCID: PMC4401833 - DOI: 10.1016/j.jacc.2015.02.034

Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J

IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins.

Cell Metab. 2015;21(4):609-21 - PMID: 25863250 - PMCID: PMC4663978 - DOI: 10.1016/j.cmet.2015.03.006

Hulsmans M, Sam F, Nahrendorf M

Monocyte and macrophage contributions to cardiac remodeling.

J Mol Cell Cardiol. 2015;93:149-55 - PMID: 26593722 - PMCID: PMC4846552 - DOI: 10.1016/j.yjmcc.2015.11.015

Emami H, Singh P, MacNabb M, Vucic E, Lavender Z, Rudd JH, Fayad ZA, Lehrer-Graiwer J, Korsgren M, Figueroa AL, Fredrickson J, Rubin B, Hoffmann U, Truong QA, Min JK, Baruch A, Nasir K, Nahrendorf M, Tawakol A

Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans.

JACC Cardiovasc Imaging. 2015;8(2):121-30 - PMID: 25577441 - PMCID: PMC6855915 - DOI: 10.1016/j.jcmg.2014.10.009

Weissleder R, Nahrendorf M

Advancing biomedical imaging.

Proc Natl Acad Sci U S A. 2015;112(47):14424-8 - PMID: 26598657 - PMCID: PMC4664297 - DOI: 10.1073/pnas.1508524112

Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M

Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction.

Circulation. 2015;132(20):1880-90 - PMID: 26358260 - PMCID: PMC4651795 - DOI: 10.1161/CIRCULATIONAHA.115.016160

Nahrendorf M, Dutta P

Targeting splenic hematopoietic stem cells in cardiovascular disease.

Oncotarget. 2015;6(24):19918-9 - PMID: 26343366 - PMCID: PMC4652955 - DOI: 10.18632/oncotarget.4918

Gonçalves I, den Ruijter H, Nahrendorf M, Pasterkamp G

Detecting the vulnerable plaque in patients.

J Intern Med. 2015;278(5):520-30 - PMID: 26306911 - DOI: 10.1111/joim.12414

He S, Chousterman BG, Fenn A, Anzai A, Nairz M, Brandt M, Hilgendorf I, Sun Y, Ye YX, Iwamoto Y, Tricot B, Weissleder R, Macphee C, Libby P, Nahrendorf M, Swirski FK

Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages.

Circ Heart Fail. 2015;8(5):980-7 - PMID: 26232205 - PMCID: PMC4568849 - DOI: 10.1161/CIRCHEARTFAILURE.115.002334

Kim JY, Ryu JH, Schellingerhout D, Sun IC, Lee SK, Jeon S, Kim J, Kwon IC, Nahrendorf M, Ahn CH, Kim K, Kim DE

Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles.

Theranostics. 2015;5(10):1098-114 - PMID: 26199648 - PMCID: PMC4508499 - DOI: 10.7150/thno.11679

Davis RW, Eggleston H, Johnson F, Nahrendorf M, Bock PE, Peterson T, Panizzi P

In Vivo Tracking of Streptococcal Infections of Subcutaneous Origin in a Murine Model.

Mol Imaging Biol. 2015;17(6):793-801 - PMID: 25921659 - PMCID: PMC4807872 - DOI: 10.1007/s11307-015-0856-2

Dutta P, Hoyer FF, Grigoryeva LS, Sager HB, Leuschner F, Courties G, Borodovsky A, Novobrantseva T, Ruda VM, Fitzgerald K, Iwamoto Y, Wojtkiewicz G, Sun Y, Da Silva N, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M

Macrophages retain hematopoietic stem cells in the spleen via VCAM-1.

J Exp Med. 2015;212(4):497-512 - PMID: 25800955 - PMCID: PMC4387283 - DOI: 10.1084/jem.20141642

Dutta P, Nahrendorf M

Monocytes in myocardial infarction.

Arterioscler Thromb Vasc Biol. 2015;35(5):1066-70 - PMID: 25792449 - PMCID: PMC4409536 - DOI: 10.1161/ATVBAHA.114.304652

Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis.

Science. 2015;347(6227):1260-5 - PMID: 25766237 - PMCID: PMC4376966 - DOI: 10.1126/science.aaa4268

Nahrendorf M, Swirski FK

Lifestyle effects on hematopoiesis and atherosclerosis.

Circ Res. 2015;116(5):884-94 - PMID: 25722442 - PMCID: PMC4347940 - DOI: 10.1161/CIRCRESAHA.116.303550

Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M

Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells.

Cell Stem Cell. 2015;16(5):477-87 - PMID: 25957903 - PMCID: PMC4426344 - DOI: 10.1016/j.stem.2015.04.008

Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK

Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.

J Exp Med. 2014;211(6):1243-56 - PMID: 24821911 - PMCID: PMC4042649 - DOI: 10.1084/jem.20131471

Courties G, Herisson F, Sager HB, Heidt T, Ye Y, Wei Y, Sun Y, Severe N, Dutta P, Scharff J, Scadden DT, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M

Ischemic stroke activates hematopoietic bone marrow stem cells.

Circ Res. 2014;116(3):407-17 - PMID: 25362208 - PMCID: PMC4312511 - DOI: 10.1161/CIRCRESAHA.116.305207

Dutta P, Nahrendorf M

Regulation and consequences of monocytosis.

Immunol Rev. 2014;262(1):167-78 - PMID: 25319334 - PMCID: PMC4203415 - DOI: 10.1111/imr.12219

Dahlman JE, Barnes C, Khan O, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, Jiang S, Seedorf D, Dave A, Sandu KS, Webber MJ, Novobrantseva T, Ruda VM, Lytton-Jean AKR, Levins CG, Kalish B, Mudge DK, Perez M, Abezgauz L, Dutta P, Smith L, Charisse K, Kieran MW, Fitzgerald K, Nahrendorf M, Danino D, Tuder RM, von Andrian UH, Akinc A, Schroeder A, Panigrahy D, Kotelianski V, Langer R, Anderson DG

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.

Nat Nanotechnol. 2014;9(8):648-655 - PMID: 24813696 - PMCID: PMC4207430 - DOI: 10.1038/nnano.2014.84

Pittet MJ, Nahrendorf M, Swirski FK

The journey from stem cell to macrophage.

Ann N Y Acad Sci. 2014;1319(1):1-18 - PMID: 24673186 - PMCID: PMC4074243 - DOI: 10.1111/nyas.12393

Panizzi P, Stone JR, Nahrendorf M

Endocarditis and molecular imaging.

J Nucl Cardiol. 2014;21(3):486-95 - PMID: 24797384 - PMCID: PMC4106242 - DOI: 10.1007/s12350-014-9902-8

Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M

Silencing of CCR2 in myocarditis.

Eur Heart J. 2014;36(23):1478-88 - PMID: 24950695 - PMCID: PMC4465633 - DOI: 10.1093/eurheartj/ehu225

Courties G, Moskowitz MA, Nahrendorf M

The innate immune system after ischemic injury: lessons to be learned from the heart and brain.

JAMA Neurol. 2014;71(2):233-6 - PMID: 24296962 - PMCID: PMC3946050 - DOI: 10.1001/jamaneurol.2013.5026

Mietto C, Pinciroli R, Piriyapatsom A, Thomas JG, Bry L, Delaney ML, Du Bois A, Truelove J, Ackman JB, Wojtkiewicz GR, Nahrendorf M, Kacmarek RM, Berra L

Tracheal tube obstruction in mechanically ventilated patients assessed by high-resolution computed tomography.

Anesthesiology. 2014;121(6):1226-35 - PMID: 25254903 - DOI: 10.1097/ALN.0000000000000455

Nahrendorf M, Swirski FK

Imaging systemic inflammation in patients with acute myocardial infarction.

Circ Cardiovasc Imaging. 2014;7(5):762-4 - PMID: 25227235 - DOI: 10.1161/CIRCIMAGING.114.002410

Swirski FK, Nahrendorf M

Do vascular smooth muscle cells differentiate to macrophages in atherosclerotic lesions?

Circ Res. 2014;115(7):605-6 - PMID: 25214571 - PMCID: PMC4166538 - DOI: 10.1161/CIRCRESAHA.114.304925

Taqueti VR, Nahrendorf M, Di Carli MF

Translational molecular imaging: repurposing an old technique to track cell migration into human atheroma.

J Am Coll Cardiol. 2014;64(10):1030-2 - PMID: 25190239 - DOI: 10.1016/j.jacc.2014.07.004

Taqueti VR, Di Carli MF, Jerosch-Herold M, Sukhova GK, Murthy VL, Folco EJ, Kwong RY, Ozaki CK, Belkin M, Nahrendorf M, Weissleder R, Libby P

Increased microvascularization and vessel permeability associate with active inflammation in human atheromata.

Circ Cardiovasc Imaging. 2014;7(6):920-9 - PMID: 25170063 - PMCID: PMC4237630 - DOI: 10.1161/CIRCIMAGING.114.002113

Nahrendorf M, Swirski FK

Regulating repair: regulatory T cells in myocardial infarction.

Circ Res. 2014;115(1):7-9 - PMID: 24951758 - PMCID: PMC4094354 - DOI: 10.1161/CIRCRESAHA.114.304295

Mulder WJ, Jaffer FA, Fayad ZA, Nahrendorf M

Imaging and nanomedicine in inflammatory atherosclerosis.

Sci Transl Med. 2014;6(239):239sr1 - PMID: 24898749 - PMCID: PMC4110972 - DOI: 10.1126/scitranslmed.3005101

Heidt T, Courties G, Dutta P, Sager HB, Sebas M, Iwamoto Y, Sun Y, Da Silva N, Panizzi P, van der Laan AM, Swirski FK, Weissleder R, Nahrendorf M

Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction.

Circ Res. 2014;115(2):284-95 - PMID: 24786973 - PMCID: PMC4082439 - DOI: 10.1161/CIRCRESAHA.115.303567

Hilgendorf I, Gerhardt LM, Tan TC, Winter C, Holderried TA, Chousterman BG, Iwamoto Y, Liao R, Zirlik A, Scherer-Crosbie M, Hedrick CC, Libby P, Nahrendorf M, Weissleder R, Swirski FK

Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium.

Circ Res. 2014;114(10):1611-22 - PMID: 24625784 - PMCID: PMC4017349 - DOI: 10.1161/CIRCRESAHA.114.303204

Nahrendorf M, Swirski FK

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Circ Res. 2014;114(5):740-1 - PMID: 24577957 - PMCID: PMC3957183 - DOI: 10.1161/CIRCRESAHA.114.303520

Frantz S, Nahrendorf M

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Cardiovasc Res. 2014;102(2):240-8 - PMID: 24501331 - PMCID: PMC3989449 - DOI: 10.1093/cvr/cvu025

Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK

Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity.

Circulation. 2014;129(16):1677-87 - PMID: 24488984 - PMCID: PMC3997655 - DOI: 10.1161/CIRCULATIONAHA.113.006381

Weissleder R, Nahrendorf M, Pittet MJ

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Nat Mater. 2014;13(2):125-38 - PMID: 24452356 - DOI: 10.1038/nmat3780

Duivenvoorden R, Tang J, Cormode DP, Mieszawska AJ, Izquierdo-Garcia D, Ozcan C, Otten MJ, Zaidi N, Lobatto ME, van Rijs SM, Priem B, Kuan EL, Martel C, Hewing B, Sager H, Nahrendorf M, Randolph GJ, Stroes ES, Fuster V, Fisher EA, Fayad ZA, Mulder WJ

A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation.

Nat Commun. 2014;5:3065 - PMID: 24445279 - PMCID: PMC4001802 - DOI: 10.1038/ncomms4065

Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M

Chronic variable stress activates hematopoietic stem cells.

Nat Med. 2014;20(7):754-758 - PMID: 24952646 - PMCID: PMC4087061 - DOI: 10.1038/nm.3589

van der Laan AM, Ter Horst EN, Delewi R, Begieneman MP, Krijnen PA, Hirsch A, Lavaei M, Nahrendorf M, Horrevoets AJ, Niessen HW, Piek JJ

Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir.

Eur Heart J. 2013;35(6):376-85 - PMID: 23966310 - PMCID: PMC3916776 - DOI: 10.1093/eurheartj/eht331

Majmudar MD, Keliher EJ, Heidt T, Leuschner F, Truelove J, Sena BF, Gorbatov R, Iwamoto Y, Dutta P, Wojtkiewicz G, Courties G, Sebas M, Borodovsky A, Fitzgerald K, Nolte MW, Dickneite G, Chen JW, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M

Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice.

Circulation. 2013;127(20):2038-46 - PMID: 23616627 - PMCID: PMC3661714 - DOI: 10.1161/CIRCULATIONAHA.112.000116

Courties G, Heidt T, Sebas M, Iwamoto Y, Jeon D, Truelove J, Tricot B, Wojtkiewicz G, Dutta P, Sager HB, Borodovsky A, Novobrantseva T, Klebanov B, Fitzgerald K, Anderson DG, Libby P, Swirski FK, Weissleder R, Nahrendorf M

In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing.

J Am Coll Cardiol. 2013;63(15):1556-66 - PMID: 24361318 - PMCID: PMC3992176 - DOI: 10.1016/j.jacc.2013.11.023

Vinegoni C, Lee S, Feruglio PF, Marzola P, Nahrendorf M, Weissleder R

Sequential average segmented microscopy for high signal-to-noise ratio motion-artifact-free in vivo heart imaging.

Biomed Opt Express. 2013;4(10):2095-106 - PMID: 24156067 - PMCID: PMC3799669 - DOI: 10.1364/BOE.4.002095

Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction.

Nat Biotechnol. 2013;31(10):898-907 - PMID: 24013197 - PMCID: PMC4058317 - DOI: 10.1038/nbt.2682

Swirski FK, Nahrendorf M

Macrophage-stem cell crosstalk after myocardial infarction.

J Am Coll Cardiol. 2013;62(20):1902-4 - PMID: 23973700 - DOI: 10.1016/j.jacc.2013.07.058

Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, Gorbatov R, Sukhova GK, Gerhardt LM, Smyth D, Zavitz CC, Shikatani EA, Parsons M, van Rooijen N, Lin HY, Husain M, Libby P, Nahrendorf M, Weissleder R, Swirski FK

Local proliferation dominates lesional macrophage accumulation in atherosclerosis.

Nat Med. 2013;19(9):1166-72 - PMID: 23933982 - PMCID: PMC3769444 - DOI: 10.1038/nm.3258

Lameijer MA, Tang J, Nahrendorf M, Beelen RH, Mulder WJ

Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease.

Expert Rev Mol Diagn. 2013;13(6):567-80 - PMID: 23895127 - PMCID: PMC4110962 - DOI: 10.1586/14737159.2013.819216

Libby P, Nahrendorf M, Swirski FK

Monocyte heterogeneity in cardiovascular disease.

Semin Immunopathol. 2013;35(5):553-62 - PMID: 23839097 - PMCID: PMC3755757 - DOI: 10.1007/s00281-013-0387-3

Ueno T, Dutta P, Keliher E, Leuschner F, Majmudar M, Marinelli B, Iwamoto Y, Figueiredo JL, Christen T, Swirski FK, Libby P, Weissleder R, Nahrendorf M

Nanoparticle PET-CT detects rejection and immunomodulation in cardiac allografts.

Circ Cardiovasc Imaging. 2013;6(4):568-73 - PMID: 23771986 - PMCID: PMC3734553 - DOI: 10.1161/CIRCIMAGING.113.000481

Nahrendorf M, Swirski FK

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Circ Res. 2013;112(12):1624-33 - PMID: 23743228 - PMCID: PMC3753681 - DOI: 10.1161/CIRCRESAHA.113.300890

Chen HH, Mekkaoui C, Cho H, Ngoy S, Marinelli B, Waterman P, Nahrendorf M, Liao R, Josephson L, Sosnovik DE

Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo.

Circ Cardiovasc Imaging. 2013;6(3):441-7 - PMID: 23537953 - PMCID: PMC3805276 - DOI: 10.1161/CIRCIMAGING.112.000074

Jung K, Kim P, Leuschner F, Gorbatov R, Kim JK, Ueno T, Nahrendorf M, Yun SH

Endoscopic time-lapse imaging of immune cells in infarcted mouse hearts.

Circ Res. 2013;112(6):891-9 - PMID: 23392842 - PMCID: PMC3834270 - DOI: 10.1161/CIRCRESAHA.111.300484

Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ

Angiotensin II drives the production of tumor-promoting macrophages.

Immunity. 2013;38(2):296-308 - PMID: 23333075 - PMCID: PMC3582771 - DOI: 10.1016/j.immuni.2012.10.015

Majmudar MD, Yoo J, Keliher EJ, Truelove JJ, Iwamoto Y, Sena B, Dutta P, Borodovsky A, Fitzgerald K, Di Carli MF, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M

Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques.

Circ Res. 2013;112(5):755-61 - PMID: 23300273 - PMCID: PMC3586287 - DOI: 10.1161/CIRCRESAHA.111.300576

van der Laan AM, Nahrendorf M, Piek JJ

Republished: healing and adverse remodelling after acute myocardial infarction: role of the cellular immune response.

Postgrad Med J. 2013;89(1047):52-8 - PMID: 23257717 - DOI: 10.1136/postgradmedj-2012-301623rep

Swirski FK, Nahrendorf M

Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure.

Science. 2013;339(6116):161-6 - PMID: 23307733 - PMCID: PMC3891792 - DOI: 10.1126/science.1230719

Novobrantseva TI, Borodovsky A, Wong J, Klebanov B, Zafari M, Yucius K, Querbes W, Ge P, Ruda VM, Milstein S, Speciner L, Duncan R, Barros S, Basha G, Cullis P, Akinc A, Donahoe JS, Narayanannair Jayaprakash K, Jayaraman M, Bogorad RL, Love K, Whitehead K, Levins C, Manoharan M, Swirski FK, Weissleder R, Langer R, Anderson DG, de Fougerolles A, Nahrendorf M, Koteliansky V

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.

Mol Ther Nucleic Acids. 2012;1(1):e4 - PMID: 23344621 - PMCID: PMC3381593 - DOI: 10.1038/mtna.2011.3

Kastrup CJ, Nahrendorf M, Figueiredo JL, Lee H, Kambhampati S, Lee T, Cho SW, Gorbatov R, Iwamoto Y, Dang TT, Dutta P, Yeon JH, Cheng H, Pritchard CD, Vegas AJ, Siegel CD, MacDougall S, Okonkwo M, Thai A, Stone JR, Coury AJ, Weissleder R, Langer R, Anderson DG

Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.

Proc Natl Acad Sci U S A. 2012;109(52):21444-9 - PMID: 23236189 - PMCID: PMC3535589 - DOI: 10.1073/pnas.1217972110

Courties G, Nahrendorf M

Enlightened stem cells in the heart: more efficient and safer reporter gene imaging.

Circ Res. 2012;111(12):1486-7 - PMID: 23223928 - DOI: 10.1161/CIRCRESAHA.112.280982

Swirski FK, Nahrendorf M

Imaging macrophage development and fate in atherosclerosis and myocardial infarction.

Immunol Cell Biol. 2012;91(4):297-303 - PMID: 23207281 - PMCID: PMC3875224 - DOI: 10.1038/icb.2012.72

Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ

Origins of tumor-associated macrophages and neutrophils.

Proc Natl Acad Sci U S A. 2012;109(7):2491-6 - PMID: 22308361 - PMCID: PMC3289379 - DOI: 10.1073/pnas.1113744109

Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo RC, Shen T, Lau FH, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten RE, Rinn JL, Cowan CA

Programming human pluripotent stem cells into white and brown adipocytes.

Nat Cell Biol. 2012;14(2):209-19 - PMID: 22246346 - PMCID: PMC3385947 - DOI: 10.1038/ncb2411

Frantz S, Hofmann U, Fraccarollo D, Schäfer A, Kranepuhl S, Hagedorn I, Nieswandt B, Nahrendorf M, Wagner H, Bayer B, Pachel C, Schön MP, Kneitz S, Bobinger T, Weidemann F, Ertl G, Bauersachs J

Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction.

FASEB J. 2012;27(3):871-81 - PMID: 23159933 - DOI: 10.1096/fj.12-214049

Chen JW, Figueiredo JL, Wojtkiewicz GR, Siegel C, Iwamoto Y, Kim DE, Nolte MW, Dickneite G, Weissleder R, Nahrendorf M

Selective factor XIIa inhibition attenuates silent brain ischemia: application of molecular imaging targeting coagulation pathway.

JACC Cardiovasc Imaging. 2012;5(11):1127-38 - PMID: 23153913 - PMCID: PMC3502014 - DOI: 10.1016/j.jcmg.2012.01.025

Sosnovik DE, Nahrendorf M

Cells and iron oxide nanoparticles on the move: magnetic resonance imaging of monocyte homing and myocardial inflammation in patients with ST-elevation myocardial infarction.

Circ Cardiovasc Imaging. 2012;5(5):551-4 - PMID: 22991284 - PMCID: PMC3529959 - DOI: 10.1161/CIRCIMAGING.112.978932

Nahrendorf M

Macrophages in the infarct: fiery friends or friendly fire?

J Mol Cell Cardiol. 2012;53(5):591-2 - PMID: 22975014 - DOI: 10.1016/j.yjmcc.2012.09.001

Lee S, Vinegoni C, Feruglio PF, Fexon L, Gorbatov R, Pivoravov M, Sbarbati A, Nahrendorf M, Weissleder R

Real-time in vivo imaging of the beating mouse heart at microscopic resolution.

Nat Commun. 2012;3:1054 - PMID: 22968700 - PMCID: PMC3622400 - DOI: 10.1038/ncomms2060

van der Laan AM, Nahrendorf M, Piek JJ

Healing and adverse remodelling after acute myocardial infarction: role of the cellular immune response.

Heart. 2012;98(18):1384-90 - PMID: 22904145 - DOI: 10.1136/heartjnl-2012-301623

Sosnovik DE, Nahrendorf M, Caravan P

Science to practice: how will myocardial inflammation be imaged with MR imaging?

Radiology. 2012;264(2):309-11 - PMID: 22821689 - PMCID: PMC6939999 - DOI: 10.1148/radiol.12121094

Xu C, Miranda-Nieves D, Ankrum JA, Matthiesen ME, Phillips JA, Roes I, Wojtkiewicz GR, Juneja V, Kultima JR, Zhao W, Vemula PK, Lin CP, Nahrendorf M, Karp JM

Tracking mesenchymal stem cells with iron oxide nanoparticle loaded poly(lactide-co-glycolide) microparticles.

Nano Lett. 2012;12(8):4131-9 - PMID: 22769232 - PMCID: PMC3552518 - DOI: 10.1021/nl301658q

Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M

Myocardial infarction accelerates atherosclerosis.

Nature. 2012;487(7407):325-9 - PMID: 22763456 - PMCID: PMC3401326 - DOI: 10.1038/nature11260

Lee H, Lytton-Jean AK, Chen Y, Love KT, Park AI, Karagiannis ED, Sehgal A, Querbes W, Zurenko CS, Jayaraman M, Peng CG, Charisse K, Borodovsky A, Manoharan M, Donahoe JS, Truelove J, Nahrendorf M, Langer R, Anderson DG

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery.

Nat Nanotechnol. 2012;7(6):389-93 - PMID: 22659608 - PMCID: PMC3898745 - DOI: 10.1038/nnano.2012.73

Degousee N, Simpson J, Fazel S, Scholich K, Angoulvant D, Angioni C, Schmidt H, Korotkova M, Stefanski E, Wang XH, Lindsay TF, Ofek E, Pierre S, Butany J, Jakobsson PJ, Keating A, Li RK, Nahrendorf M, Geisslinger G, Backx PH, Rubin BB

Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction.

Circulation. 2012;125(23):2904-13 - PMID: 22589381 - DOI: 10.1161/CIRCULATIONAHA.112.099754

Vinegoni C, Fumene Feruglio P, Razansky D, Gorbatov R, Ntziachristos V, Sbarbati A, Nahrendorf M, Weissleder R

Mapping molecular agents distributions in whole mice hearts using born-normalized optical projection tomography.

PLoS One. 2012;7(4):e34427 - PMID: 22509302 - PMCID: PMC3324534 - DOI: 10.1371/journal.pone.0034427

Cheng H, Byrska-Bishop M, Zhang CT, Kastrup CJ, Hwang NS, Tai AK, Lee WW, Xu X, Nahrendorf M, Langer R, Anderson DG

Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics.

Biomaterials. 2012;33(20):5004-12 - PMID: 22494889 - PMCID: PMC3366278 - DOI: 10.1016/j.biomaterials.2012.03.065

Majmudar MD, Nahrendorf M

Cardiovascular molecular imaging: the road ahead.

J Nucl Med. 2012;53(5):673-6 - PMID: 22492729 - PMCID: PMC3744821 - DOI: 10.2967/jnumed.111.099838

Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier R, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ

Regulation of monocyte functional heterogeneity by miR-146a and Relb.

Cell Rep. 2012;1(4):317-24 - PMID: 22545247 - PMCID: PMC3334310 - DOI: 10.1016/j.celrep.2012.02.009

Nahrendorf M, McCarthy JR, Libby P

Over a hump for imaging atherosclerosis: nanobodies visualize vascular cell adhesion molecule-1 in inflamed plaque.

Circ Res. 2012;110(7):902-3 - PMID: 22461358 - DOI: 10.1161/CIRCRESAHA.112.267260

Swirski FK, Nahrendorf M, Libby P

The ins and outs of inflammatory cells in atheromata.

Cell Metab. 2012;15(2):135-6 - PMID: 22326216 - DOI: 10.1016/j.cmet.2012.01.012

Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK

Innate response activator B cells protect against microbial sepsis.

Science. 2012;335(6068):597-601 - PMID: 22245738 - PMCID: PMC3279743 - DOI: 10.1126/science.1215173

Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.

J Exp Med. 2012;209(1):123-37 - PMID: 22213805 - PMCID: PMC3260875 - DOI: 10.1084/jem.20111009

Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, Dutta P, Iwamoto Y, Ueno T, Begieneman MP, Niessen HW, Piek JJ, Vinegoni C, Pittet MJ, Swirski FK, Tawakol A, Di Carli M, Weissleder R, Nahrendorf M

PET/MRI of inflammation in myocardial infarction.

J Am Coll Cardiol. 2012;59(2):153-63 - PMID: 22222080 - PMCID: PMC3257823 - DOI: 10.1016/j.jacc.2011.08.066

Su HS, Nahrendorf M, Panizzi P, Breckwoldt MO, Rodriguez E, Iwamoto Y, Aikawa E, Weissleder R, Chen JW

Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase.

Radiology. 2011;262(1):181-90 - PMID: 22084204 - PMCID: PMC3244672 - DOI: 10.1148/radiol.11110040

Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R

In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.

Nat Med. 2011;17(9):1142-6 - PMID: 21857652 - PMCID: PMC3169740 - DOI: 10.1038/nm.2423

Leuschner F, Nahrendorf M

Molecular imaging of coronary atherosclerosis and myocardial infarction: considerations for the bench and perspectives for the clinic.

Circ Res. 2011;108(5):593-606 - PMID: 21372291 - PMCID: PMC3397211 - DOI: 10.1161/CIRCRESAHA.110.232678

Xu C, Mu L, Roes I, Miranda-Nieves D, Nahrendorf M, Ankrum JA, Zhao W, Karp JM

Nanoparticle-based monitoring of cell therapy.

Nanotechnology. 2011;22(49):494001 - PMID: 22101191 - PMCID: PMC3334527 - DOI: 10.1088/0957-4484/22/49/494001

Shon SM, Park JH, Nahrendorf M, Schellingerhout D, Kim JY, Kang BT, Jeong SW, Kim EJ, Ryu JH, Kim K, Kwon IC, Lee DK, Lee MM, Kim DE

Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque.

Atherosclerosis. 2011;216(1):67-73 - PMID: 21334624 - DOI: 10.1016/j.atherosclerosis.2011.01.036

Keliher EJ, Yoo J, Nahrendorf M, Lewis JS, Marinelli B, Newton A, Pittet MJ, Weissleder R

89Zr-labeled dextran nanoparticles allow in vivo macrophage imaging.

Bioconjug Chem. 2011;22(12):2383-9 - PMID: 22035047 - PMCID: PMC3244512 - DOI: 10.1021/bc200405d

Kim DE, Kim JY, Nahrendorf M, Lee SK, Ryu JH, Kim K, Kwon IC, Schellingerhout D

Direct thrombus imaging as a means to control the variability of mouse embolic infarct models: the role of optical molecular imaging.

Stroke. 2011;42(12):3566-73 - PMID: 22020025 - DOI: 10.1161/STROKEAHA.111.629428

Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B, Panizzi P, Lee WW, Iwamoto Y, Milstein S, Epstein-Barash H, Cantley W, Wong J, Cortez-Retamozo V, Newton A, Love K, Libby P, Pittet MJ, Swirski FK, Koteliansky V, Langer R, Weissleder R, Anderson DG, Nahrendorf M

Therapeutic siRNA silencing in inflammatory monocytes in mice.

Nat Biotechnol. 2011;29(11):1005-10 - PMID: 21983520 - PMCID: PMC3212614 - DOI: 10.1038/nbt.1989

Nahrendorf M, Sosnovik DE

Science to practice: will magnetic guidance of microbubbles play a role in clinical molecular imaging?

Radiology. 2011;260(2):309-10 - PMID: 21778448 - DOI: 10.1148/radiol.11111017

Nahrendorf M

Imaging of infarct healing predicts left ventricular remodeling and evolution of heart failure: focus on protease activity.

Circ Cardiovasc Imaging. 2011;4(4):351-3 - PMID: 21772011 - PMCID: PMC3141180 - DOI: 10.1161/CIRCIMAGING.111.966671

Buxton DB, Antman M, Danthi N, Dilsizian V, Fayad ZA, Garcia MJ, Jaff MR, Klimas M, Libby P, Nahrendorf M, Sinusas AJ, Wickline SA, Wu JC, Bonow RO, Weissleder R

Report of the National Heart, Lung, and Blood Institute working group on the translation of cardiovascular molecular imaging.

Circulation. 2011;123(19):2157-63 - PMID: 21576680 - PMCID: PMC3119488 - DOI: 10.1161/CIRCULATIONAHA.110.000943

Laha M, Panizzi P, Nahrendorf M, Bock PE

Engineering streptokinase for generation of active site-labeled plasminogen analogs.

Anal Biochem. 2011;415(2):105-15 - PMID: 21570944 - PMCID: PMC3114107 - DOI: 10.1016/j.ab.2011.04.025

Nordbeck P, Hiller KH, Fidler F, Warmuth M, Burkard N, Nahrendorf M, Jakob PM, Quick HH, Ertl G, Bauer WR, Ritter O

Feasibility of contrast-enhanced and nonenhanced MRI for intraprocedural and postprocedural lesion visualization in interventional electrophysiology: animal studies and early delineation of isthmus ablation lesions in patients with typical atrial flutter.

Circ Cardiovasc Imaging. 2011;4(3):282-94 - PMID: 21415125 - DOI: 10.1161/CIRCIMAGING.110.957670

Nahrendorf M, Keliher E, Marinelli B, Leuschner F, Robbins CS, Gerszten RE, Pittet MJ, Swirski FK, Weissleder R

Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography.

Arterioscler Thromb Vasc Biol. 2011;31(4):750-7 - PMID: 21252070 - PMCID: PMC3060293 - DOI: 10.1161/ATVBAHA.110.221499

Figueiredo JL, Nahrendorf M, Vinegoni C, Weissleder R

Intraoperative near-infrared fluorescent cholangiography (NIRFC) in mouse models of bile duct injury: reply.

World J Surg. 2011;35(3):694-5 - PMID: 20645091 - DOI: 10.1007/s00268-010-0728-5

Bratlie KM, Dang TT, Lyle S, Nahrendorf M, Weissleder R, Langer R, Anderson DG

Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models.

PLoS One. 2010;5(4):e10032 - PMID: 20386609 - PMCID: PMC2850367 - DOI: 10.1371/journal.pone.0010032

Leuschner F, Panizzi P, Chico-Calero I, Lee WW, Ueno T, Cortez-Retamozo V, Waterman P, Gorbatov R, Marinelli B, Iwamoto Y, Chudnovskiy A, Figueiredo JL, Sosnovik DE, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M

Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction.

Circ Res. 2010;107(11):1364-73 - PMID: 20930148 - PMCID: PMC2992104 - DOI: 10.1161/CIRCRESAHA.110.227454

Swirski FK, Wildgruber M, Ueno T, Figueiredo JL, Panizzi P, Iwamoto Y, Zhang E, Stone JR, Rodriguez E, Chen JW, Pittet MJ, Weissleder R, Nahrendorf M

Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice.

J Clin Invest. 2010;120(7):2627-34 - PMID: 20577051 - PMCID: PMC2898607 - DOI: 10.1172/JCI42304

Libby P, Nahrendorf M, Weissleder R

Molecular imaging of atherosclerosis: a progress report.

Tex Heart Inst J. 2010;37(3):324-7 - PMID: 20548813 - PMCID: PMC2879214

Nahrendorf M, Pittet MJ, Swirski FK

Monocytes: protagonists of infarct inflammation and repair after myocardial infarction.

Circulation. 2010;121(22):2437-45 - PMID: 20530020 - PMCID: PMC2892474 - DOI: 10.1161/CIRCULATIONAHA.109.916346

Lee DK, Nahrendorf M, Schellingerhout D, Kim DE

Will molecular optical imaging have clinically important roles in stroke management, and how?

J Clin Neurol. 2010;6(1):10-8 - PMID: 20386638 - PMCID: PMC2851295 - DOI: 10.3988/jcn.2010.6.1.10

Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF, Fexon L, Pivovarov M, Swirski FK, Pittet MJ, Vinegoni C, Weissleder R

Hybrid PET-optical imaging using targeted probes.

Proc Natl Acad Sci U S A. 2010;107(17):7910-5 - PMID: 20385821 - PMCID: PMC2867879 - DOI: 10.1073/pnas.0915163107

Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M

Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.

J Am Coll Cardiol. 2010;55(15):1629-38 - PMID: 20378083 - PMCID: PMC2852892 - DOI: 10.1016/j.jacc.2009.08.089

Figueiredo JL, Siegel C, Nahrendorf M, Weissleder R

Intraoperative near-infrared fluorescent cholangiography (NIRFC) in mouse models of bile duct injury.

World J Surg. 2010;34(2):336-43 - PMID: 20033407 - PMCID: PMC2809822 - DOI: 10.1007/s00268-009-0332-8

Vinegoni C, Fexon L, Feruglio PF, Pivovarov M, Figueiredo JL, Nahrendorf M, Pozzo A, Sbarbati A, Weissleder R

High throughput transmission optical projection tomography using low cost graphics processing unit.

Opt Express. 2009;17(25):22320-32 - PMID: 20052155 - PMCID: PMC2805020 - DOI: 10.1364/OE.17.022320

Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A

Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.

Circ Cardiovasc Imaging. 2009;2(6):468-75 - PMID: 19920045 - PMCID: PMC2782621 - DOI: 10.1161/CIRCIMAGING.109.863779

Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L

Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia.

Circ Cardiovasc Imaging. 2009;2(6):460-7 - PMID: 19920044 - PMCID: PMC2780438 - DOI: 10.1161/CIRCIMAGING.109.859678

Matter CM, Stuber M, Nahrendorf M

Imaging of the unstable plaque: how far have we got?

Eur Heart J. 2009;30(21):2566-74 - PMID: 19833636 - PMCID: PMC2771148 - DOI: 10.1093/eurheartj/ehp419

Nahrendorf M, Keliher E, Panizzi P, Zhang H, Hembrador S, Figueiredo JL, Aikawa E, Kelly K, Libby P, Weissleder R

18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis.

JACC Cardiovasc Imaging. 2009;2(10):1213-22 - PMID: 19833312 - PMCID: PMC2773129 - DOI: 10.1016/j.jcmg.2009.04.016

Panizzi P, Nahrendorf M, Wildgruber M, Waterman P, Figueiredo JL, Aikawa E, McCarthy J, Weissleder R, Hilderbrand SA

Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation.

J Am Chem Soc. 2009;131(43):15739-44 - PMID: 19817443 - PMCID: PMC2773134 - DOI: 10.1021/ja903922u

Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ

Identification of splenic reservoir monocytes and their deployment to inflammatory sites.

Science. 2009;325(5940):612-6 - PMID: 19644120 - PMCID: PMC2803111 - DOI: 10.1126/science.1175202

Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R

Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors.

Arterioscler Thromb Vasc Biol. 2009;29(10):1444-51 - PMID: 19608968 - PMCID: PMC2746251 - DOI: 10.1161/ATVBAHA.109.193086

Nordbeck P, Bauer WR, Fidler F, Warmuth M, Hiller KH, Nahrendorf M, Maxfield M, Wurtz S, Geistert W, Broscheit J, Jakob PM, Ritter O

Feasibility of real-time MRI with a novel carbon catheter for interventional electrophysiology.

Circ Arrhythm Electrophysiol. 2009;2(3):258-67 - PMID: 19808476 - DOI: 10.1161/CIRCEP.108.778357

Figueiredo JL, Nahrendorf M, Sosnovik DE, Weissleder R

MRI of a novel murine working heart transplant model.

Circ Heart Fail. 2009;2(3):272-4 - PMID: 19718275 - PMCID: PMC2733535 - DOI: 10.1161/CIRCHEARTFAILURE.109.852707

Wildgruber M, Lee H, Chudnovskiy A, Yoon TJ, Etzrodt M, Pittet MJ, Nahrendorf M, Croce K, Libby P, Weissleder R, Swirski FK

Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors.

PLoS One. 2009;4(5):e5663 - PMID: 19461894 - PMCID: PMC2680949 - DOI: 10.1371/journal.pone.0005663

Vinegoni C, Razansky D, Figueiredo JL, Fexon L, Pivovarov M, Nahrendorf M, Ntziachristos V, Weissleder R

Born normalization for fluorescence optical projection tomography for whole heart imaging.

J Vis Exp. 2009;(28):ePub - PMID: 19578329 - PMCID: PMC2794886 - DOI: 10.3791/1389

Leimgruber A, Berger C, Cortez-Retamozo V, Etzrodt M, Newton AP, Waterman P, Figueiredo JL, Kohler RH, Elpek N, Mempel TR, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ

Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle.

Neoplasia. 2009;11(5):459-68, 2 p following 468 - PMID: 19412430 - PMCID: PMC2672160 - DOI: 10.1593/neo.09356

Christen T, Nahrendorf M, Wildgruber M, Swirski FK, Aikawa E, Waterman P, Shimizu K, Weissleder R, Libby P

Molecular imaging of innate immune cell function in transplant rejection.

Circulation. 2009;119(14):1925-32 - PMID: 19332470 - PMCID: PMC2676889 - DOI: 10.1161/CIRCULATIONAHA.108.796888

Vinegoni C, Razansky D, Figueiredo JL, Nahrendorf M, Ntziachristos V, Weissleder R

Normalized Born ratio for fluorescence optical projection tomography.

Opt Lett. 2009;34(3):319-21 - PMID: 19183644 - PMCID: PMC2771918 - DOI: 10.1364/ol.34.000319

Kelly KA, Shaw SY, Nahrendorf M, Kristoff K, Aikawa E, Schreiber SL, Clemons PA, Weissleder R

Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.

Integr Biol (Camb). 2009;1(4):311-7 - PMID: 20023731 - PMCID: PMC2748356 - DOI: 10.1039/b821775k

Nahrendorf M, Sosnovik DE, French BA, Swirski FK, Bengel F, Sadeghi MM, Lindner JR, Wu JC, Kraitchman DL, Fayad ZA, Sinusas AJ

Multimodality cardiovascular molecular imaging, Part II.

Circ Cardiovasc Imaging. 2009;2(1):56-70 - PMID: 19808565 - PMCID: PMC2760054 - DOI: 10.1161/CIRCIMAGING.108.839092

Devaraj NK, Keliher EJ, Thurber GM, Nahrendorf M, Weissleder R

18F labeled nanoparticles for in vivo PET-CT imaging.

Bioconjug Chem. 2009;20(2):397-401 - PMID: 19138113 - PMCID: PMC2644737 - DOI: 10.1021/bc8004649

Sinusas AJ, Bengel F, Nahrendorf M, Epstein FH, Wu JC, Villanueva FS, Fayad ZA, Gropler RJ

Multimodality cardiovascular molecular imaging, part I.

Circ Cardiovasc Imaging. 2008;1(3):244-56 - PMID: 19808549 - DOI: 10.1161/CIRCIMAGING.108.824359

Cortez-Retamozo V, Swirski FK, Waterman P, Yuan H, Figueiredo JL, Newton AP, Upadhyay R, Vinegoni C, Kohler R, Blois J, Smith A, Nahrendorf M, Josephson L, Weissleder R, Pittet MJ

Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation.

J Clin Invest. 2008;118(12):4058-66 - PMID: 19033674 - PMCID: PMC2579705 - DOI: 10.1172/JCI36335

Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne SW, Blankesteijn WM, Sosnovik DE, Jaffer FA, Tung CH, Weissleder R

Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction.

Eur Heart J. 2008;29(4):445-54 - PMID: 18276618 - DOI: 10.1093/eurheartj/ehm558

Sosnovik DE, Nahrendorf M, Weissleder R

Targeted imaging of myocardial damage.

Nat Clin Pract Cardiovasc Med. 2008;5 Suppl 2(Suppl 2):S63-70 - PMID: 18641609 - PMCID: PMC2597275 - DOI: 10.1038/ncpcardio1115

Libby P, Nahrendorf M, Pittet MJ, Swirski FK

Diversity of denizens of the atherosclerotic plaque: not all monocytes are created equal.

Circulation. 2008;117(25):3168-70 - PMID: 18574058 - DOI: 10.1161/CIRCULATIONAHA.108.783068

Nahrendorf M, Sosnovik DE, Weissleder R

MR-optical imaging of cardiovascular molecular targets.

Basic Res Cardiol. 2008;103(2):87-94 - PMID: 18324364 - PMCID: PMC2664635 - DOI: 10.1007/s00395-008-0707-2

Sosnovik DE, Nahrendorf M, Weissleder R

Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications.

Basic Res Cardiol. 2008;103(2):122-30 - PMID: 18324368 - PMCID: PMC2597271 - DOI: 10.1007/s00395-008-0710-7

Nahrendorf M, Sosnovik D, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R

Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury.

Circulation. 2008;117(9):1153-60 - PMID: 18268141 - PMCID: PMC2673051 - DOI: 10.1161/CIRCULATIONAHA.107.756510

Sosnovik DE, Dai G, Nahrendorf M, Rosen BR, Seethamraju R

Cardiac MRI in mice at 9.4 Tesla with a transmit-receive surface coil and a cardiac-tailored intensity-correction algorithm.

J Magn Reson Imaging. 2007;26(2):279-87 - PMID: 17654729 - DOI: 10.1002/jmri.20966

Wei CL, Valvano JW, Feldman MD, Nahrendorf M, Peshock R, Pearce JA

Volume catheter parallel conductance varies between end-systole and end-diastole.

IEEE Trans Biomed Eng. 2007;54(8):1480-9 - PMID: 17694869 - DOI: 10.1109/TBME.2007.890732

Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.

J Exp Med. 2007;204(12):3037-47 - PMID: 18025128 - PMCID: PMC2118517 - DOI: 10.1084/jem.20070885

Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik DE, Aikawa E, Libby P, Swirski FK, Weissleder R

Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis.

Circulation. 2007;117(3):379-87 - PMID: 18158358 - PMCID: PMC2663426 - DOI: 10.1161/CIRCULATIONAHA.107.741181

Aikawa E, Nahrendorf M, Figueiredo JL, Swirski FK, Shtatland T, Kohler RH, Jaffer FA, Aikawa M, Weissleder R

Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.

Circulation. 2007;116(24):2841-50 - PMID: 18040026 - DOI: 10.1161/CIRCULATIONAHA.107.732867

Pittet MJ, Grimm J, Berger CR, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski FK, Weissleder R

In vivo imaging of T cell delivery to tumors after adoptive transfer therapy.

Proc Natl Acad Sci U S A. 2007;104(30):12457-61 - PMID: 17640914 - PMCID: PMC1941490 - DOI: 10.1073/pnas.0704460104

Sosnovik DE, Nahrendorf M, Weissleder R

Molecular magnetic resonance imaging in cardiovascular medicine.

Circulation. 2007;115(15):2076-86 - PMID: 17438163 - DOI: 10.1161/CIRCULATIONAHA.106.658930

Nahrendorf M, Sosnovik DE, Waterman P, Swirski FK, Pande AN, Aikawa E, Figueiredo JL, Pittet MJ, Weissleder R

Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct.

Circ Res. 2007;100(8):1218-25 - PMID: 17379832 - DOI: 10.1161/01.RES.0000265064.46075.31

Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V

Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo.

Circulation. 2007;115(11):1384-91 - PMID: 17339546 - DOI: 10.1161/CIRCULATIONAHA.106.663351

Nahrendorf M, Badea C, Hedlund LW, Figueiredo JL, Sosnovik DE, Johnson GA, Weissleder R

High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT.

Am J Physiol Heart Circ Physiol. 2007;292(6):H3172-8 - PMID: 17322414 - PMCID: PMC2680216 - DOI: 10.1152/ajpheart.01307.2006

Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R

Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.

Circulation. 2007;115(3):377-86 - PMID: 17224478 - DOI: 10.1161/CIRCULATIONAHA.106.654913

Nahrendorf M, Weissleder R

[Advances in cardiovascular medicine through molecular imaging].

Radiologe. 2007;47(1):18-24 - PMID: 17187263 - DOI: 10.1007/s00117-006-1450-z

Nahrendorf M, Streif JU, Hiller KH, Hu K, Nordbeck P, Ritter O, Sosnovik D, Bauer L, Neubauer S, Jakob PM, Ertl G, Spindler M, Bauer WR

Multimodal functional cardiac MRI in creatine kinase-deficient mice reveals subtle abnormalities in myocardial perfusion and mechanics.

Am J Physiol Heart Circ Physiol. 2006;290(6):H2516-21 - PMID: 16415075 - DOI: 10.1152/ajpheart.01038.2005

Hiller KH, Waller C, Nahrendorf M, Bauer WR, Jakob PM

Assessment of cardiovascular apoptosis in the isolated rat heart by magnetic resonance molecular imaging.

Mol Imaging. 2006;5(2):115-21 - PMID: 16954025

Nahrendorf M, Weissleder R, Ertl G

Does FXIII deficiency impair wound healing after myocardial infarction?

PLoS One. 2006;1(1):e48 - PMID: 17183677 - PMCID: PMC1762326 - DOI: 10.1371/journal.pone.0000048

Jaffer FA, Sosnovik DE, Nahrendorf M, Weissleder R

Molecular imaging of myocardial infarction.

J Mol Cell Cardiol. 2006;41(6):921-33 - PMID: 17067633 - DOI: 10.1016/j.yjmcc.2006.09.008

Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R

Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis.

Circulation. 2006;114(14):1504-11 - PMID: 17000904 - DOI: 10.1161/CIRCULATIONAHA.106.646380

Jaffer FA, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R

Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials.

Mol Imaging. 2006;5(2):85-92 - PMID: 16954022

Kelly KA, Nahrendorf M, Yu AM, Reynolds F, Weissleder R

In vivo phage display selection yields atherosclerotic plaque targeted peptides for imaging.

Mol Imaging Biol. 2006;8(4):201-7 - PMID: 16791746 - DOI: 10.1007/s11307-006-0043-6

Nahrendorf M, Hu K, Frantz S, Jaffer FA, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlöhner S, Novikov M, Dickneite G, Reed GL, Jakob P, Rosenzweig A, Bauer WR, Weissleder R, Ertl G

Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction.

Circulation. 2006;113(9):1196-202 - PMID: 16505171 - PMCID: PMC4066325 - DOI: 10.1161/CIRCULATIONAHA.105.602094

Pelzer T, Jazbutyte V, Hu K, Segerer S, Nahrendorf M, Nordbeck P, Bonz AW, Muck J, Fritzemeier KH, Hegele-Hartung C, Ertl G, Neyses L

The estrogen receptor-alpha agonist 16alpha-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats.

Cardiovasc Res. 2005;67(4):604-12 - PMID: 15950203 - DOI: 10.1016/j.cardiores.2005.04.035

Nahrendorf M, Spindler M, Hu K, Bauer L, Ritter O, Nordbeck P, Quaschning T, Hiller KH, Wallis J, Ertl G, Bauer WR, Neubauer S

Creatine kinase knockout mice show left ventricular hypertrophy and dilatation, but unaltered remodeling post-myocardial infarction.

Cardiovasc Res. 2005;65(2):419-27 - PMID: 15639481 - DOI: 10.1016/j.cardiores.2004.10.006

Streif JU, Nahrendorf M, Hiller KH, Waller C, Wiesmann F, Rommel E, Haase A, Bauer WR

In vivo assessment of absolute perfusion and intracapillary blood volume in the murine myocardium by spin labeling magnetic resonance imaging.

Magn Reson Med. 2005;53(3):584-92 - PMID: 15723416 - DOI: 10.1002/mrm.20327

Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L

Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle.

Magn Reson Med. 2005;54(3):718-24 - PMID: 16086367 - DOI: 10.1002/mrm.20617

Nahrendorf M, Hiller KH, Hu K, Zeijlemaker V, Griswold M, Bauer WR

Pacing in high field cardiac magnetic resonance imaging:

Pacing Clin Electrophysiol. 2004;27(5):671-4 - PMID: 15125728 - DOI: 10.1111/j.1540-8159.2004.00506.x

Wiesmann F, Herold V, Streiff JU, Nahrendorf M, Neubauer S, Rommel E, Haase A

Novel insights into LV remodeling after murine myocardial infarction by in vivo magnetic resonance tissue velocity mapping.

Int J Cardiovasc Imaging. 2004;20(4):289-91 - PMID: 15529911 - DOI: 10.1023/b:caim.0000041945.64887.f4

Neuberger T, Greiser A, Nahrendorf M, Jakob PM, Faber C, Webb AG

23Na microscopy of the mouse heart in vivo using density-weighted chemical shift imaging.

MAGMA. 2004;17(3-6):196-200 - PMID: 15580377 - DOI: 10.1007/s10334-004-0048-6

Streif JU, Hiller KH, Waller C, Nahrendorf M, Wiesmann F, Bauer WR, Rommel E, Haase A

In vivo assessment of absolute perfusion in the murine skeletal muscle with spin labeling MRI. Magnetic resonance imaging.

J Magn Reson Imaging. 2003;17(1):147-52 - PMID: 12500285 - DOI: 10.1002/jmri.10229

Streif JU, Herold V, Szimtenings M, Lanz TE, Nahrendorf M, Wiesmann F, Rommel E, Haase A

In vivo time-resolved quantitative motion mapping of the murine myocardium with phase contrast MRI.

Magn Reson Med. 2003;49(2):315-21 - PMID: 12541252 - DOI: 10.1002/mrm.10342

Waller C, Hiller KH, Albrecht M, Hu K, Nahrendorf M, Gattenlöhner S, Haase A, Ertl G, Bauer WR

Microvascular adaptation to coronary stenosis in the rat heart in vivo: a serial magnetic resonance imaging study.

Microvasc Res. 2003;66(3):173-82 - PMID: 14609522 - DOI: 10.1016/s0026-2862(03)00058-x

Nahrendorf M, Frantz S, Hu K, von zur Mühlen C, Tomaszewski M, Scheuermann H, Kaiser R, Jazbutyte V, Beer S, Bauer W, Neubauer S, Ertl G, Allolio B, Callies F

Effect of testosterone on post-myocardial infarction remodeling and function.

Cardiovasc Res. 2003;57(2):370-8 - PMID: 12566109 - DOI: 10.1016/s0008-6363(02)00701-0

Nahrendorf M, Hiller KH, Greiser A, Kohler S, Neuberger T, Hu K, Waller C, Albrecht M, Neubauer S, Haase A, Ertl G, Bauer WR

Chronic coronary artery stenosis induces impaired function of remote myocardium: MRI and spectroscopy study in rat.

Am J Physiol Heart Circ Physiol. 2003;285(6):H2712-21 - PMID: 12933339 - DOI: 10.1152/ajpheart.00233.2003

Nahrendorf M, Hiller KH, Hu K, Ertl G, Haase A, Bauer WR

Cardiac magnetic resonance imaging in small animal models of human heart failure.

Med Image Anal. 2003;7(3):369-75 - PMID: 12946475 - DOI: 10.1016/s1361-8415(03)00011-2

Nahrendorf M, Hiller KH, Theisen D, Hu K, Waller C, Kaiser R, Haase A, Ertl G, Brinkmann R, Bauer WR

Effect of transmyocardial laser revascularization on myocardial perfusion and left ventricular remodeling after myocardial infarction in rats.

Radiology. 2002;225(2):487-93 - PMID: 12409584 - DOI: 10.1148/radiol.2252011325

Nahrendorf M, Hu K, Hiller KH, Galuppo P, Fraccarollo D, Schweizer G, Haase A, Ertl G, Bauer WR, Bauersachs J

Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction: an experimental serial cardiac magnetic resonance imaging study.

J Am Coll Cardiol. 2002;40(9):1695-700 - PMID: 12427425 - DOI: 10.1016/s0735-1097(02)02375-6

Nahrendorf M, Hu K, Fraccarollo D, Hiller KH, Haase A, Bauer WR, Ertl G

Time course of right ventricular remodeling in rats with experimental myocardial infarction.

Am J Physiol Heart Circ Physiol. 2002;284(1):H241-8 - PMID: 12388245 - DOI: 10.1152/ajpheart.00537.2002

Waller C, Hiller KH, Kahler E, Hu K, Nahrendorf M, Voll S, Haase A, Ertl G, Bauer WR

Serial magnetic resonance imaging of microvascular remodeling in the infarcted rat heart.

Circulation. 2001;103(11):1564-9 - PMID: 11257086 - DOI: 10.1161/01.cir.103.11.1564

Nahrendorf M, Wiesmann F, Hiller KH, Hu K, Waller C, Ruff J, Lanz TE, Neubauer S, Haase A, Ertl G, Bauer WR

Serial cine-magnetic resonance imaging of left ventricular remodeling after myocardial infarction in rats.

J Magn Reson Imaging. 2001;14(5):547-55 - PMID: 11747006 - DOI: 10.1002/jmri.1218

Waller C, Kahler E, Hiller KH, Hu K, Nahrendorf M, Voll S, Haase A, Ertl G, Bauer WR

Myocardial perfusion and intracapillary blood volume in rats at rest and with coronary dilatation: MR imaging in vivo with use of a spin-labeling technique.

Radiology. 2000;215(1):189-97 - PMID: 10751486 - DOI: 10.1148/radiology.215.1.r00ap07189

Nahrendorf M, Wiesmann F, Hiller KH, Han H, Hu K, Waller C, Ruff J, Haase A, Ertl G, Bauer WR

In vivo assessment of cardiac remodeling after myocardial infarction in rats by cine-magnetic resonance imaging.

J Cardiovasc Magn Reson. 2000;2(3):171-80 - PMID: 11545114 - DOI: 10.3109/10976640009146565

Hu K, Gaudron P, Anders HJ, Weidemann F, Turschner O, Nahrendorf M, Ertl G

Chronic effects of early started angiotensin converting enzyme inhibition and angiotensin AT1-receptor subtype blockade in rats with myocardial infarction: role of bradykinin.

Cardiovasc Res. 1998;39(2):401-12 - PMID: 9798525 - DOI: 10.1016/s0008-6363(98)00090-x

Nahrendorf Lab