David R. Elmaleh

Professional Positions

1971-1973	Instructor in the Casali Institute of Applied Chemistry and Assistant to the Director, the late Professor J.E. Jolles, Hebrew University of Jerusalem
1975-1976	Research Associate, Department of Medicinal Chemistry and Pharmacology, College of Pharmacy and Allied Health Professions, Northeastern University, Boston, MA; the synthesis of CNS drugs with Professor J.L. Neumeyer
1976-1978	Assistant in Chemistry, Department of Radiology, Massachusetts General Hospital, Boston, MA
1978-1980	Assistant Chemist, Department of Radiology, Massachusetts General Hospital, Boston, MA
1978	Research Member, Harvard MIT Division of Health Sciences and Technology, Cambridge, MA
1980	Associate Radiochemist, Department of Radiology, Physics Research Laboratory, Massachusetts General Hospital, Boston, MA
1981-1985	Assistant Professor of Radiology, Harvard Medical School, Boston, MA
1984	Director, Contrast Media Chemistry, Division of Radiological Sciences, Department of Radiology, Massachusetts General Hospital, Boston, MA
1984	Associate Professor of Radiology, Harvard Medical School Boston, MA

Other Appointments

1995-2000	Member, Scientific Advisory Board, IGG International, Boston, MA
1997-2002	Chairman, Director and Scientific Founder, Biostream Inc. (currently Molecular Insight Pharmaceuticals, Inc.), Cambridge, MA
1998	Director, US Biosystems, Boca- Raton, FL
1999	Member of three NIH study sections (RO1, SBIR, R21, R33 )
2000-2001	Founder, Director, Scientific Advisory Board, Nanopharma LLC (Currently Mersana Inc.) Cambridge, MA
2000	Scientific Advisory Board, Puretech Ventures LLC (Boston MA)
2004-2012	Founder, Director, Scientific Advisory Board, FluoroPharma Inc. (Boston, MA)
2011	Founder, Director, Scientific Advisor, AZTherapies Inc., (Boston, MA)

Awards and Honors

• The Histraduth Young Scientist Award
• The Kathelyne Casali Award for Applied Chemistry
• Several NIH RO1, DOE and SBIR awards

Major areas of interest and future goals

• Capture medical technologies at their inception for developing novel drugs and healthcare products for the future
• Focusing on improving human health care using novel approaches for early diagnosis and follow-up treatment
• Clinical trial design for Alzheimer’s treatment
• Drug design and discovery
• Radiopharmaceutical development, biological evaluation of new agents
• Radioactive tracer kinetic analysis in physiology and medicine
• Development of agents and/or biomarkers for assessment of (a) central nervous system receptors, energy metabolism and cerebral blood flow, (b) myocardial function
• Drug/Device applications in Medicine

Patents

partial list of 116 patents

US20140140927	Cromolyn derivatives and their related methods of imaging and treatment (2014)
WO2010088455	Preparation of cromolyn derivatives as imaging and pharmaceutical agents (2010)
US20090191125A1	Diagnostic and Therapeutic Alkyl Piperidine/Piperazine Compounds and Process Compounds and Process (2009)
WO2009117728	Compounds and compositions for the detection and treatment of Alzheimer’s disease and related disorders (2009)
US2008267879	Novel imaging tracers for early detection and treatment of amyloid plaques caused by Alzheimer’s disease and related disorders (2008)
US7438893	Polybiotin Compounds for magnetic resonance imaging and drug delivery (2008)
US7438891	Imaging Agents for early detection and monitoring of cardiovascular plaque (2008)
WO2007123934	Aryl bidentate isonitrile radionuclide metal chelate compounds and conjugates, and their uses for diagnostic and therapeutic purposes (2007)
US20060035828A1	Direct activation of AtIII in whole blood and plasma (2006)
WO2005082425	Catalytic radiofluorination (2005)