Sepulcre Lab

About the lab

PI: Jorge Sepulcre

The Sepulcre lab focuses on brain imaging studies aiming at the understanding of large-scale brain networks implicated in human cognition and neurodegenerative disorders. We also devote a substantial part of our work developing cutting-edge network methodologies for different brain imaging modalities such as functional connectivity MRI and PET imaging.


Our specific research interest aligns with the following topics:

  • Systems Neuroscience
  • Brain Functional Streams
  • Brain Hierarchical Organization
  • Multimodal Sensory Integration
  • Language Neuroarchitecture
  • Neurodegenerative Disorders

Link to research page.



    Research Assistants

    Research Fellows:
    Laura Ortiz-Teran
    Ibai Diez Palacio


    Selected Publications

    • Diez I, Larson AG, Nakhate V, Dunn EC, Fricchione GL, Nicholson TR, Sepulcre J, Perez DL. Early-life trauma endophenotypes and brain circuit-gene expression relationships in functional neurological (conversion) disorder. Mol. Psychiatry 2020; ():
      View in: PubMed
    • Costumero V, d’Oleire Uquillas F, Diez I, Andorrà M, Basaia S, Bueichekú E, Ortiz-Terán L, Belloch V, Escudero J, Ávila C, Sepulcre J. Distance disintegration delineates the brain connectivity failure of Alzheimer’s disease. Neurobiol. Aging 2020; 88():51-60
      View in: PubMed
    • Bueichekú E, Aznárez-Sanado M, Diez I, d’Oleire Uquillas F, Ortiz-Terán L, Qureshi AY, Suñol M, Basaia S, Ortiz-Terán E, Pastor MA, Sepulcre J. Central neurogenetic signatures of the visuomotor integration system. Proc. Natl. Acad. Sci. U.S.A. 2020; 117(12):6836-6843
      View in: PubMed
    • Benito-Aragón C, Gonzalez-Sarmiento R, Liddell T, Diez I, d’Oleire Uquillas F, Ortiz-Terán L, Bueichekú E, Chow HM, Chang SE, Sepulcre J. Neurofilament-lysosomal genetic intersections in the cortical network of stuttering. Prog. Neurobiol. 2020; 184:101718
      View in: PubMed
    • Bueichekú E, Ávila C, Miró-Padilla A, Sepulcre J. Visual search task immediate training effects on task-related functional connectivity. Brain Imaging Behav 2019; 13(6):1566-1579
      View inPubMed
    • Qian J, Diez I, Ortiz-Terán L, Bonadio C, Liddell T, Goñi J, Sepulcre J. Positive Connectivity Predicts the Dynamic Intrinsic Topology of the Human Brain Network. Front Syst Neurosci 2018; 12:38
      View inPubMed
    • Diez I, Sepulcre J. Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain. Nat Commun 2018; 9(1):3876
      View inPubMed
    • Ruiz de Miras J, Costumero V, Belloch V, Escudero J, Ávila C, Sepulcre J. Complexity analysis of cortical surface detects changes in future Alzheimer’s disease converters. Hum Brain Mapp 2017; 38(12):5905-5918
      View in: PubMed
    • Ortiz-Terán L, Diez I, Ortiz T, Perez DL, Aragón JI, Costumero V, Pascual-Leone A, El Fakhri G, Sepulcre J. Brain circuit-gene expression relationships and neuroplasticity of multisensory cortices in blind children. Proc. Natl. Acad. Sci. U.S.A. 2017; 114(26):6830-6835
      View in: PubMed
    • Sepulcre J, Grothe MJ, Sabuncu M, Chhatwal J, Schultz AP, Hanseeuw B, El Fakhri G, Sperling R, Johnson KA. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurol 2017; 74(7):813-820
      View in: PubMed
    • Prčkovska V, Huijbers W, Schultz A, Ortiz-Teran L, Peña-Gomez C, Villoslada P, Johnson K, Sperling R, Sepulcre J. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Hum Brain Mapp 2017; 38(4):1965-1976
      View in: PubMed
    • Ortiz-Teran L, Ortiz T, Perez DL, Aragon JI, Diez I, Pascual-Leone A, Sepulcre J. Brain Plasticity in Blind Subjects Centralizes Beyond the Modal Cortices. Front Syst Neurosci 2016; 10():61
    • Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. J. Neurosci. 2016; 36(28):7364-74
    • Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann. Neurol. 2016; 79(1):110-9
    • Hu C, Sepulcre J, Johnson KA, Fakhri GE, Lu YM, Li Q. Matched signal detection on graphs: Theory and application to brain imaging data classification. Neuroimage 2016; 125():587-600
    • Sepulcre J, Masdeu JC. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease. Methods Mol. Biol. 2016; 1303():509-19
    • Sepulcre J. An OP4 functional stream in the language-related neuroarchitecture. Cereb. Cortex 2015; 25(3):658-66
    • Sepulcre J. Functional streams and cortical integration in the human brain. Neuroscientist. 2014 Oct; 20(5):499-508.
    • Sepulcre J. Integration of visual and motor functional streams in the human brain. Neuroscience Letters. 2014 May 1; 567:68-73.

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