Choi Lab

About the lab

PI: Hak Soo Choi

Dr. Choi’s laboratory focuses on the development of novel contrast agents for tissue- and organ-specific targeting and diagnosis. Of particular interest is “Structure-Inherent Targeting,” where small molecules can be used for targeting, imaging, diagnosis and therapy by specifically visualizing target tissue with high optical properties and by avoiding nonspecific uptake in normal background tissues.

Research

Development of targeted multifunctional nanoprobes for pancreatic neuroendocrine tumors 

Pancreatic neuroendocrine tumors cannot be adequately treated using conventional treatments and remain an unanswered health concern. Nanoprobes can provide sensitive and specific imaging of pancreatic neuroendocrine tumors for early diagnosis, site-specific delivery of chemotherapeutic agents, and laparoscopic image-guided surgery.

Members

Students

Research Assistants

    Selected Publications

    • Ji Y, Jones C, Baek Y, Park GK, Kashiwagi S, Choi HS. Near-infrared fluorescence imaging in immunotherapy. Adv. Drug Deliv. Rev. 2020; ():
      View in: PubMed
    • Choi HS, Kim HK. Multispectral image-guided surgery in patients. Nat Biomed Eng 2020; 4(3):245-246
      View in: PubMed
    • Katagiri W, Lee G, Tanushi A, Tsukada K, Choi HS, Kashiwagi S. High-throughput single-cell live imaging of photobiomodulation with multispectral near-infrared lasers in cultured T cells. J Biomed Opt 2020; 25(3):1-18
      View in: PubMed
    • Lee JH, Jung SY, Park GK, Bao K, Hyun H, El Fakhri G, Choi HS. Fluorometric Imaging for Early Diagnosis and Prognosis of Rheumatoid Arthritis. Adv Sci (Weinh) 2020; 7(1):1902267
      View in: PubMed
    • Kang H, Stiles WR, Baek Y, Nomura S, Bao K, Hu S, Park GK, Jo MJ, I H, Coll JL, Rubin BP, Choi HS. Renal Clearable Theranostic Nanoplatforms for Gastrointestinal Stromal Tumors. Adv. Mater. Weinheim 2019; ():e1905899
      View in: PubMed
    • Kang H, Rho S, Stiles WR, Hu S, Baek Y, Hwang DW, Kashiwagi S, Kim MS, Choi HS. Size-Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting. Adv Healthc Mater 2019; 9(1):e1901223
      View in: PubMed
    • Ji Y, Wang Z, Bao K, Park GK, Kang H, Hu S, McDonald E, Kim MS, Kashiwagi S, Choi HS. Targeted molecular imaging of TLR4 in hepatocellular carcinoma using zwitterionic near-infrared fluorophores. Quant Imaging Med Surg 2019; 9(9):1548-1555
      View in: PubMed
    • Yang C, Park GK, McDonald EJ, Choi HS. Targeted Near-Infrared Fluorescence Imaging for Regenerative Medicine. Tissue Eng Regen Med 2019; 16(5):433-442
      View in: PubMed
    • Das P, Santos S, Park GK, Hoseok I, Choi HS. Real-Time Fluorescence Imaging in Thoracic Surgery. Korean J Thorac Cardiovasc Surg 2019; 52(4):205-220
      View in: PubMed
    • Sajedi S, Sabet H, Choi HS. Intraoperative biophotonic imaging systems for image-guided interventions. Nanophotonics 2019; 8(1):99-116
      View in: PubMed
    • Park GK, Lee JH, Levitz A, El Fakhri G, Hwang NS, Henary M, Choi HS. Lysosome-Targeted Bioprobes for Sequential Cell Tracking from Macroscopic to Microscopic Scales. Adv. Mater. Weinheim 2019; 31(14):e1806216
      View in: PubMed
    • Son J, Yi G, Yoo J, Park C, Koo H, Choi HS. Light-responsive nanomedicine for biophotonic imaging and targeted therapy. Adv. Drug Deliv. Rev. 2019; 138:133-147
      View in: PubMed
    • Wada H, Hyun H, Bao K, Lee JH, El Fakhri G, Choi Y, Choi HS. Multivalent Mannose-Decorated NIR Nanoprobes for Targeting Pan Lymph Nodes. Chem Eng J 2018; 340():51-57
      View in: PubMed
    • Hu S, Kang H, Baek Y, El Fakhri G, Kuang A, Choi HS. Real-Time Imaging of Brain Tumor for Image-Guided Surgery. Adv Healthc Mater 2018; ():e1800066
      View in: PubMed
    • Bao K, Lee JH, Kang H, Park GK, El Fakhri G, Choi HS. PSMA-targeted contrast agents for intraoperative imaging of prostate cancer. Chem. Commun. (Camb.) 2017; 53(10):1611-1614
      View in: PubMed
    • Choi NC, Gainor J, Ackman J, Lim R, Sharp GC, El Fakhri G, Niemierko A. ORAL02.03: Robust Correlation Between Metabolic Response Measured with F-FDG PET Soon After Therapy and Clinical Outcome in Lung Cancer: Topic: Radiation Oncology. J Thorac Oncol 2016; 11(11S):S253-S254
      View in: PubMed
    • Koo H, Lee JH, Bao K, Wu Y, El Fakhri G, Henary M, Yun SH, Choi HS. Site-Specific In Vivo Bioorthogonal Ligation via Chemical Modulation. Adv Healthc Mater 2016; 5(19):2510-2516
      View in: PubMed
    • Owens EA, Henary M, El Fakhri G, Choi HS. Tissue-Specific Near-Infrared Fluorescence Imaging. Acc. Chem. Res. 2016; 49(9):1731-40
      View in: PubMed
    • Ashitate Y, Levitz A, Park MH, Hyun H, Venugopal V, Park G, El Fakhri G, Henary M, Gioux S, Frangioni JV, Choi HS. Endocrine-specific NIR fluorophores for adrenal gland targeting. Chem. Commun. (Camb.) 2016; 52(67):10305-8
      View in: PubMed
    • Kang H, Gravier J, Bao K, Wada H, Lee JH, Baek Y, El Fakhri G, Gioux S, Rubin BP, Coll JL, Choi HS. Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery. Adv. Mater. Weinheim 2016; 28(37):8162-8168
      View in: PubMed

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