HST 565 Medical Imaging Sciences and Applications, Fall 2022

Week

Date

Suggested Literature

Description

1

Thur 9/8/2022

  SC12 Chp. 1, 15

Introduction to molecular imaging

(Georges El Fakhri)

Covers types of imaging modalities used in medicine (MRI, US, PET, SPECT, CT) providing an overview of the applications in medical imaging and how they complement each other (i.e. what does MRI do that CT does not and v.v., what does PET do and SPECT cannot and v.v.; these are covered at an application level, where advantages/disadvantages are mentioned from a pathology detection perspective).

2

Tues 9/13/2022

SC12 Chp. 3, 4, 6

Radioactive Decay, Particle Interactions, Dose and Exposure  

(Moses Wilks)

Covers the basics of nuclear physics, and implications from exposure to radiation.

2

Thur 9/15/2022

SC12 Chp. 11, 12

Radiation detectors, Counting Statistics I

(Hamid Sabet)

Covers the physics of radiation detection and different types of detectors (gas, semiconductors and scintillators), as well as the basics of counting statistics.

3

Tues 9/20/2022

SC12 Chp. 11, 12

Radiation detectors, Counting Statistics II

(Hamid Sabet)

Covers types of radiation detector systems (PMT, monolithic crystals, solid state, pixelated crystals) and their applications to imaging systems, event positioning algorithms (advantages and disadvantages, and possibility for improvement), how the physical 222properties and (mechanical) design of crystals provides potential for the improvement of image quality.

3

Thur 9/22/2022

SC12 Chp. 16

Introduction to Tomographic Imaging

(Moses Wilks)

Covers topics in transmission tomography imaging, such as the mathematics of computed tomography (parallel, fan-beam, and cone-beam integral transforms), analytic reconstruction algorithms (FPB, FBP, etc.).

4

Tues 9/27/2022

SC12 Chp. 17, MW04 Chps. 7 & 2,

Single Photon Emission Computed Tomography

(Hamid Sabet)

Covers topics in SPECT acquisition such as artifacts during acquisition (e.g. center-of-rotation artifacts), and principles of collimation (compatibility with radiotracer, collimator-detector response compensation including intrinsic response, geometric response, and septal penetration/scatter response), flood-field uniformity correction, attenuation correction, scatter correction, and partial voluming.

4

Thur 9/29/2022

Review of Problem Set 1

5

Tues 10/4/2022

SC12 Chp. 18

Positron Emission Tomography I

(Nicolas Guehl)

Topics on the fundamentals of Positron Emission Tomography.

5

Thur 10/6/2022

SC12 Chp. 18

Positron Emission Tomography II

(Georges El Fakhri)

Expanded topics on PET Imaging Acquisition and Corrections

6

Thur 10/11/2021

Indigenous Peoples Day

6

Thur 10/13/2022

SC12 Chp. 21

CT: Analog, Digital, Dual Energy, and Proton

(Bill Worstell)

Covers physical principles of X-ray computed tomography (Hounsfield units, types of acquisitions, detectors, etc.), artifacts arising from the physics of CT (beam hardening, low-dose), and artifact correction methods

7

Tues 10/18/2022

Problem Set II

(Staff)

Review of problem set 2

7

Tues 10/20/2022

Handouts

Iterative Tomographic Reconstruction

(Kuang Gong)

Covers the Bayesian framework under which iterative tomographic reconstruction is interpreted (this includes a detailed explanation of Expectation Maximization), followed by a presentation of the MLEM algorithm, and continued by an introduction to maximum a posteriori (MAP) methods of image reconstruction (modeling of the prior distribution, anatomical priors, bias on the solution, penalty/regularization term in optimization).

8

Tues 10/25/2022

Handouts

Radiochemistry for Molecular Imaging I

(Pedro Brugarolas)

Covers fundamentals of radiochemistry, and a survey of radiochemistry techniques with regards to specific radiotracers and their clinical/experimental applications

8

Thur 10/27/2022

Radiochemistry for Molecular Imaging II

(Pedro Brugarolas)

9

Tues 11/01/2021

Midterm Exam

(Staff)

9

Thur 11/3/2022

Handouts

Kinetic Modeling of Physiologic Data I

(Nicolas Guehl)

10

Tues 11/8/2022

Handouts

Kinetic Modeling of Physiologic Data II

(Marc Normandin)

10

Thur 11/10/2022

Clinical PET

(Thomas Ng)

Covers common uses of PET in clinical practice, including common tracers, diseases, and complications of clinical interest.

11

Magnetic Resonance Imaging I (Jonghye Woo)

Covers topics in MR physics (magnetization, relaxation, Bloch equations), signal detection concepts, basics of multi-dimensional MR Imaging (slice selection, phase and frequency encoding).

11

Thur 11/17/2022

Magnetic Resonance Imaging II

(Chao Ma)

Covers topics on interpretation of k-space, signal in k-space, sampling and aliasing, signal/contrast/noise, and basics of acquisition (spin echo, gradient echo).

12

Tues 11/22/2022

Problem Set III

(Staff)

12

Thur 11/24/2021

Thanksgiving Holiday

13

Tues 11/29/2022

Handouts

Ultrasound Imaging

(Viksit Kumar)

Topics in ultrasound elastography will be discussed, the physical basis and clinical context in which this technology is applied, through the framework of precision medicine for diffuse liver disease.

13

Tues 12/01/2022

Handouts

Optical Imaging and Immunotherapy

(Satoshi Kashiwagi)

Covers topics in optical fluorescence imaging and immunotherapy using near-infrared fluorescence imaging devices and targeted contrast agents.

14

Thur 12/6/2022

Handouts

Nanomedicine: From Small Molecules to Nanoparticles

(Kai Bao and Homan Kang)

Covers topics in design and applications of targeted contrast agents ranging from small molecules to nanoparticles for nanomedicine and image-guided surgery.

14

Tues 12/8/2022

Image Guided Brain Therapies

(Emiliano Santarnecchi)

15

Thur 12/13/2022

Problem Set IV and Multimodality Imaging

(Moses Wilks)

Review of Problem Set IV & Covers topics in multi-modality imaging such as challenges in simultaneous acquisition (providing an overview of state of the art image registration methods that may be used to fuse the modalities), and hybrid imaging for PET/MR and PET/CT comparing advances in each modality

16

Tues 12/20/2022

Final Exam

(Staff)

Covers material from all lectures – Held in lecture hall from 4:30-6:00 pm