Ren Lab

About the lab

PI: Jian Ren

The Ren lab aims to discover and understand the fundamentals of complex biological systems at the ‘ground truth’ level through developing systematic and scalable imaging and mapping methodologies. Specifically, we integrate optical, biochemical, and computational approaches to enable quantitative investigation in fully-assembled biological systems, such as brains.

Research

• High-throughput volumetric optical imaging 

• Long-lasting nano-scale proteomic contrast synthesis

• Cross-scale cross-modality image validation, graph analysis, and topological abstraction

Members

Selected Publications

• J. Ren, M. Shishkov, M. Villiger, K. Otsuka, S. Nadkarni, and B. Bouma, ‘Single-catheter dual-modality intravascular imaging combining IVUS and OFDI: A holistic structural visualization of coronary arteries’, EuroIntervention, vol. 17, no. 11, e919-e922, DOI: 10.4244/EIJ-D-20-00990, December 2021
• K. Otsuka, M. Villiger, A. Karanasos, L. van Zandvoort, P. Doradla, J. Ren, N. Lippok, J. Daemen, R. Diletti, R. van Geuns, F. Zijlstra, G. van Soest, J. Dijkstra, P. Libby, S. K. Nadkarni, E. Regar and B. E. Bouma, ‘Intravascular polarimetry in patients with coronary artery disease’, Journal of the American College of Cardiology (JACC):Cardiovascular Imaging, https://doi.org/10.1016/j.jcmg.2019.06.015
• A. S. Nam, J. Ren, B. E. Bouma and B. J. Vakoc, ‘Demonstration of triband multi-focal imaging with optical coherence tomography’, Applied Sciences, vol. 8, no. 12, 2395, November 2018
• M. Villiger, K. Otsuka, A. Karanasos, P. Doradla, J. Ren, N. Lippok, M. Shishkov, J. Daemen, R. Diletti, R. van Geuns, F. Zijlstra, J. Dijkstra, G. van Soest, E. Regar, S. K. Nadkarni and B. E. Bouma, ‘Repeatability assessment of intravascular polarimetry in patients’, IEEE Transactions on Medical Imaging, vol. 37, no. 7, pp. 1618-1625, July 2018
• K. Beaudette, M. Strupler, J. Ren, B. E. Bouma and C. Boudoux, ‘A radiometric model for coaxial single- and multi-mode optical emission from double-clad fiber’, Applied Optics, vol. 57, no. 5, pp. 1110-1118, February 2018
• M. Villiger, A. Karanasos, P. Doradla, K. Otsuka, J. Ren, N. Lippok, M. Shishkov, J. Daemen, R. Diletti, R. van Geuns, F. Zijlstra, G. van Soest, P. Libby, E. Regar, S. K. Nadkarni and B. E. Bouma, ‘Coronary plaque microstructure and composition modify optical polarization: A new endogenous contrast mechanism for optical frequency domain imaging’, Journal of the American College of Cardiology (JACC): Cardiovascular Imaging, https://doi.org/10.1016/j.jcmg.2017.09.023
• J. Ren, H. Choi, K. Chung and B. E. Bouma, ‘Label-free volumetric optical imaging of intact murine brains’, Scientific Reports, vol. 7, 46306; doi: 10.1038/srep46306, April 2017
• J. Ren, ‘Dispersion analysis and measurement of potassium tantalate niobate crystals by broadband optical interferometers’, Applied Optics, vol. 56, no. 2, pp. 234-238, January 2017

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