Quanzheng Li, Ph.D.

Associate Physicist, MGH
Associate Professor, HMS

Contact Info:

Nuclear Medicine and Molecular Imaging
Radiology Department
White 427
55 Fruit Street
Boston, MA 02114


(617) 643-9481

(617) 726-6165

Bio Sketch

  • 1992   B.S., Biomedical Engineering, Zhejiang University, Hangzhou, Zhejiang, China
  • 1997   M.S., Biomedical Engineering, Tsinghua University, Beijing, China
  • 2005   Ph.D., Electrical Engineering, University of Southern California, Los Angeles, USA

Research interests

Dr. Quanzheng Li is Associate Physicist at Massachusetts General Hospital and Associate Professor at Harvard Medical School. His research interests include:

  • Static and Dynamic Model based image reconstruction of MRI, CT and PET
  • Kinetic modeling of dynamic PET and MRI images
  • Direct estimation of parametric image
  • Computer-aided diagnosis for small lesion detection

Selected Publications

See Harvard Catalyst for more publications


  • Sitek A, Li Q, El Fakhri G, Alpert NM. Validation of Bayesian analysis of compartmental kinetic models in medical imaging. Phys Med 2016;
    View in: PubMed
  • Wang M, Guo N, Hu G, El Fakhri G, Zhang H, Li Q. A novel approach to assess the treatment response using Gaussian random field in PET. Med Phys 2016; 43(2):833-42
    View in: PubMed
  • Grogg KS, Toole T, Ouyang J, Zhu X, Normandin MD, Li Q, Johnson K, Alpert NM, El Fakhri G. National Electrical Manufacturers Association and Clinical Evaluation of a Novel Brain PET/CT Scanner. J. Nucl. Med. 2016; 57(4):646-52
    View in: PubMed
  • Hu C, Sepulcre J, Johnson KA, Fakhri GE, Lu YM, Li Q. Matched signal detection on graphs: Theory and application to brain imaging data classification. Neuroimage 2016; 125():587-600
    View in: PubMed


  • Dutta J, Huang C, Li Q, El Fakhri G. Pulmonary imaging using respiratory motion compensated simultaneous PET/MR. Med Phys 2015; 42(7):4227-40
    View in: PubMed


  • Lorsakul A, Li Q, Trott CM, Hoog C, Petibon Y, Ouyang J, Laine AF, El Fakhri G. 4D numerical observer for lesion detection in respiratory-gated PET. Med Phys 2014; 41(10):102504
    View in: PubMed
  • W. Zhu, Q. Li, B Bai, PS Conti, RM Leahy. Patlak image estimation from dual time-point list-mode PET data. IEEE Trans. Medical Imaging 2014 Apr; 33(4):913-24.
  • Y. Petibon, C. Huang, J. Ouyang, T. G Reese, Q. Li, S. Syrkina, Y-L Chen and G. El Fakhri. Relative role of motion and PSF compensation in whole-body oncologic PET-MR imaging. Medical Physics, in press, 2014
  • Bai B, Lin Y, Zhu W, Ren R, Li Q, Dahlbom M, Difilippo F, Leahy RM. MAP reconstruction for Fourier rebinned TOF-PET data. Phys Med Biol. 2014 Feb 21; 59(4):925-49.
    View in: PubMed
  • Y. Lin, J. P. Haldar, Q. Li and R. M. Leahy. Sparse Constrained Mixture Modeling for the Estimation of Kinetic Parameters in Dynamic PET. IEEE Transactions on Medical Imaging. 2014; 33(1):173-185.
  • Guo J, Guo N, Lang L, Kiesewetter DO, Xie Q, Li Q, Eden HS, Niu G, Chen X. 18F-Alfatide II and 18F-FDG Dual-Tracer Dynamic PET for Parametric, Early Prediction of Tumor Response to Therapy. J Nucl Med. 2014 Jan; 55(1):154-60.
    View in: PubMed


  • Dutta J, Leahy RM, Li Q. Non-Local Means Denoising of Dynamic PET Images. PLoS One. 2013; 8(12):e81390.
    View in: PubMed
  • Dutta J, Ahn S, Li Q. Quantitative statistical methods for image quality assessment. Theranostics. 2013; 3(10):741-56.
    View in: PubMed
  • Rakvongthai Y, Ouyang J, Guerin B, Li Q, Alpert NM, El Fakhri G. Direct reconstruction of cardiac PET kinetic parametric images using a preconditioned conjugate gradient approach. Med Phys. 2013 Oct; 40(10):102501.
    View in: PubMed
  • Li Q. Quantitative methods for molecular diagnostic and therapeutic imaging. Theranostics. 2013; 3(10):729-30.
    View in: PubMed
  • Fisher BE, Li Q, Nacca A, Salem GJ, Song J, Yip J, Hui JS, Jakowec MW, Petzinger GM. Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease. Neuroreport. 2013 Jul 10; 24(10):509-14.
    View in: PubMed
  • Y. Petibon, J. Ouyang, T. G. Reese, C. Huang, X. Zhu, S. Y. Chun, Q. Li and G El Fakhri. A cardiac phantom study using simultaneous PET-MR defect detection. Physics in Medicine and Biology. 2013; 59(7):2085-2102.
  • C. Hu, L. Cheng, J. Sepulcre, G. El Fakhri, Y. M. Lu and Q. Li. Matched Signal Detection on Graphs: Theory and Application to Brain Network Classification. Information Processing in Medical Imaging, Lecture Notes in Computer Science. 2013; 7917:1-12.
  • Ouyang J, Li Q, El Fakhri G. Magnetic resonance-based motion correction for positron emission tomography imaging. Semin Nucl Med. 2013 Jan; 43(1):60-7.
    View in: PubMed
  • Bai B, Li Q, Leahy RM. Magnetic resonance-guided positron emission tomography image reconstruction. Semin Nucl Med. 2013 Jan; 43(1):30-44.
    View in: PubMed


  • Zhu L, Guo N, Li Q, Ma Y, Jacboson O, Lee S, Choi HS, Mansfield JR, Niu G, Chen X. Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe. Theranostics. 2012; 2(8):746-56.
    View in: PubMed


  • S. Somayajula, C. Panagiotou, A. Rangarajan, Q. Li, S. R. Arridge, R. M. Leahy. PET Image Reconstruction Using Information Theoretic Anatomical Priors, IEEE Trans. Med. Imag., vol.30, no. 3, pp:537-549, 2011
  • S. Ahn, S. Cho, Q. Li, Y. Lin and R. M. Leahy. Optimal Rebinning of Time-of-Flight PET Data, IEEE Trans. Med. Imag., vol. 30, no. 10, pp:1808-1818, 2011


  • M. G. Vucckovic, Q. Li, B. Fisher, A. Nacca, R. M. Leahy, J. P. Walsh, J. Mukherjee, C. Williams, M. M. Jakowec and G. M. Petzinger . Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: In vivo imaging with [18F] fallypride, Movement Disorders, vol. 25, no. 16, pp: 2777-2784, 2010


  • Z. Li, Q.Li, D. Pantazis, X.Yu, R.M. Leahy. Controlling Familywise Error Rate for Matched Subspace Detection in Dynamic FDG PET, IEEE Trans. Med. Imag., vol.28, no. 10, pp:1623-1631, 2009
  • Z. Li, Q. Li, X. Yu, P. Conti, RM Leahy, Lesion Detection in Dynamic FDG-PET Using Matched Subspace Detection, IEEE Trans. Med. Imag., vol.28, no. 2, pp:230-40, 2009
  • S Cho, S. Ahn, Q Li, RM Leahy, Exact and Approximate Fourier Rebinning of PET Data from Time-of-Flight to Non Time-of-Flight, Phys. Med Bio. (2009) 54:467-484


  • S. Cho, S. Ahn, Q. Li, RM Leahy, Analytical properties of time-of-flight PET data, Phys. Med. Bio, 53:2809-2821, 2008.
  • S. Cho, S. Ahn, Q. Li and R.M. Leahy, Analytical Properties of TOF PET data , Physics in Medicine and Biology, vol. 53, no. 11, pp:2809:2821, 2008


    Q. Li, E. Asma, S. Ahn and R.M. Leahy, A Fast Fully 4D Incremental Gradient Reconstruction Algorithm for List Mode PET Data, IEEE Transactions on Medical Imaging, vol. 26, no. 1, pp:58--67, 2007.


  • Q. Li and R. M. Leahy, Statistics of Randoms Pre-corrected Data and Its Application to PET Reconstruction, IEEE Transactions on Medical Imaging, vol. 25, no. 12, pp:1565--1572, 2006.


  • Q. Li, E. Asma, J. Qi, J. R. Bading and R. M. Leahy, Accurate Estimation of the Fisher Information Matrix for the PET Image Reconstruction Problem, IEEE Transactions on Medical Imaging, vol. 23, no. 9, pp:1057--1064, Sept. 2004.
  • Y. Yang, Y.C. Tai, S. Siege, D.F. Newport, B. Bai, Q. Li, R.M.Leahy and S.R. Cherry, Optimization and Performance Evaluation of the microPET II Scanner for In Vivo Small-Animal Imaging, Physics in Medicine and Biology, Vol. 49(2004), pp:2527--2545.

See Harvard Catalyst for more publications