Marc D. Normandin

Current and previous work includes the development and application of tracer kinetic modeling techniques and design of experiments for quantification of:

• Simultaneous PET/fMRI measurements of receptor-ligand binding and cerebral hemodynamics
• Influence of neuropharmacological processes on local and network-level fMRI signal kinetics
• Molecular and structural pathology in traumatic brain injury and neurodegenerative diseases
• Cerebral cannabinoid receptors in substance abuse, post-traumatic stress disorder, and schizophrenia
• Pancreatic beta-cell mass and islet pathology in juvenile (type 1) and adult-onset (type 2) diabetes
• Cardiac perfusion, metabolism, and mitochondrial function in coronary artery disease
• Dopamine receptors, transporters and transmission in substance abuse, mood disorders, motor activity and cognition
• Regional brain metabolism and mitochondrial expression in stroke and assessment of therapeutic interventions
• Assessment of macromolecules as agents for imaging and drug delivery
• Evaluation of new radiopharmaceuticals and in vivo target engagement by therapeutic drugs