Recent Posts


Select Category

Gordon Lecture: Radiopharmaceutical Therapy: History, Current Status and Future Potential

06/04/2019


Bennett S. Greenspan, M.D., M.S. received his M.D. degree from the University of Illinois in Chicago. He completed residencies in Diagnostic Radiology and Nuclear Medicine and is certified in Diagnostic Radiology and Nuclear Radiology by the ABR and in Nuclear Medicine by the ABNM. He received the M.S. degree in medical physics from UCLA. Dr. Greenspan is devoted to teaching of clinical nuclear medicine and also physics and radiation safety of nuclear medicine to nuclear medicine and radiology residents.  He is also keenly interested in quality and safety in Nuclear Medicine.
Below is a summary of his presentation

History - Radiopharmaceutical therapy began in 1941 with the efforts and insight of Saul Hertz, MD of MGH and also Arthur Roberts, PhD of MIT. From that beginning, I-131 has become an important agent for the treatment of benign and malignant thyroid disease. In the 1980s, two agents, Sr-89 chloride and Sm-153 EDTMP, were introduced for bone pain palliation. Somatostatin receptor targeted therapies were developed in the 1980s and 1990s, leading to FDA-approval of Lu-177 Dotatate in 2018. Radiolabeled antibodies were also being developed in the 1970s – 2000s, with the introduction of two agents in 2002 and 2003. Radium-223 dichloride was approved by the FDA in 2013 for treatment of castrate-resistant metastatic prostate cancer.

Read more...

Gordon Lecture: Preoperative and Intraoperative Localization for Pulmonary nodule


Dr. Hyun Koo Kim is Professor and Chief of Thoracic and Cardiovascular Surgery at the Korea University Guro Hospital in Seoul, Korea. He earned his medical degree from Korea University College of Medicine in Seoul Korea in 1996. He finished a Thoracic and Cardiovascular Surgery residency in 2001 and afterwards completed a fellowship in the Korea University Guro Hospital in 2005. He is an expertise in single port VATS and utilizing 3D thoracoscope during VATS.
Below is a summary of his presentation

Image-guided surgery can be defined as surgery where the operator utilizes surgical devices that incorporate the use of tracking technology in conjunction with a fusion of images in order to guide surgical procedures. 

Preoperative marking via CT-guided localization is the most commonly used techniques for thoracoscopic surgery-based resection of small peripheral pulmonary nodules. But, it was related with resulting in higher rates of pneumothorax, bleeding, and dislodgement.Preoperative marking via CT-guided localization is the most commonly used techniques for thoracoscopic surgery-based resection of small peripheral pulmonary nodules. But, it was related with resulting in higher rates of pneumothorax, bleeding, and dislodgement.

Read more...

Gordon Lecture: Advanced MRIs in CNS

05/20/2019


Dr. Meiyun Wang is a neuroradiologist, Professor and Chair of the Medical Imaging Center of Henan Province and Chair of the Department of Radiology of Henan Provincial People’s Hospital. She received her M.D. from Southeast University in 1995, a PhD from Capital University of Medical Sciences in 2005, and then worked as a post-doctoral research fellow at the Massachusetts General Hospital, Harvard Medical School from 2006-2008. She became the Vice-Chair in 2008 Chair in 2016 of the Department of Radiology of Henan Provincial People’s Hospital in China.
Below is a summary of her presentation.

In this talk, the applications of three non-contrast enhanced advanced MR techniques, including Diffusion Kurtosis Imaging (DKI), Strategically Acquired Gradient Echo (STAGE) and a Length and Offset Varied Saturation (LOVARS) in central nervous system (CNS) were summarized.

DKI has been used to measure non-Gaussian diffusion, which has the potential to characterize both normal and pathologic tissue better than diffusion-tensor imaging. Some previous researchers have suggested that DKI might provide more accurate information about water diffusion. Dr. Wang's study showed that mean kurtosis values may provide additional information and improve the grading of gliomas compared with conventional diffusion parameters.

STAGE is an advanced Susceptibility weighted imaging (SWI) which can provide multi-contrast images in one scan, such as T1W, PDW, T1 MAP, PD MAP, R2* MAP, SWI, and even MRA images in 5 minutes. It is very helpful in early detecting and evaluating ischemia, brain trauma and some other CNS diseases.

Read more...

Gordon Lecture Series: Learning reconstruction and analysis for medical imaging

05/13/2019


Dr. Shanshan Wang is an associate professor at Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. She received her dual Ph.D degree from the University of Sydney and Shanghai Jiaotong University respectively in information technologies and biomedical engineering. Dr. Wang was a finalist for the Australian John Makepeace Bennett Best Thesis Award and won the 2018 OCSMRM Outstanding Research Award. Her research interests include machine learning, fast medical imaging and biomedical signal analysis.
Below is a summary of her presentation

Inverse problems are ubiquitous in the field of medical imaging and image processing. Prominent examples include fast MR imaging and image denoising. The goal of these problems is to reconstruct or restore an unknown image from a set of direct/indirect measurements. However, due to the limitation of the acquisition time or the existence of noise, the obtained measurements are often corrupted or incomplete, which introduces big challenges for the reconstruction process and the following clinical diagnosis. In order to remove the noise or overcome the ill-posed nature caused by the insufficient measurements, it is necessary to explore the prior knowledge and utilize them to form constraints in the reconstruction process so as to make up for the missing or corrupted information.

Read more...
Dr. Kwon

Gordon Lecture: Activatable Molecular Probes for Optical Imaging

05/06/2019


Dr. Ick Chan Kwon is a Presidential Scholar at KIST-DFCI On-Site-Lab in Department of Cancer Biology, Dana Farber Cancer Institute Boston. He is a Tenured Principal Research Scientist of Korea Institute of Science and Technology (KIST). He received his B.S. and M.S. degrees in College of Engineering at Seoul National University and his Ph. D. in Pharmaceutics and Pharmaceutical Chemistry from University of Utah. After a post-doctoral training at CCCD in University of Utah, he joined KIST where he started his research on polymeric nanoparticle-based drug delivery system for antibiotics, anticancer drugs and gene therapy. He also pioneered in a research filed of Theragnosis, by combining molecular imaging and drug delivery system with smart nano-probes. He is a fellow of The Korean Academy of Science & Technology and a member of The National Academy of Engineering of Korea.
Below is a summary of his presentation

Dr. Kwon

For decades, molecular imaging which can monitor inter-/intracellular functions or molecular processes in an organism has provided valuable information for various research fields. Biomarkers such as enzymes, receptors and proteins can be utilized as a target of molecular imaging since they can provide information for early diagnosis and monitoring therapeutic effect of diseases. Among them, receptor-ligand interaction based molecular imaging technique has been emerging promising strategy in theragnosis of intractable diseases such as cancer.
In this talk, Dr. Kwon introduced epidermal growth factor receptor (EGFR) and CD 47 receptor-specific self-quenched imaging probes, which can emit fluorescence (activate) via de-quenching reaction in lysosome. His talk also included a simple noninvasive labeling and tracking technique for cell therapeutics via combination of metabolic glycoengineering and biootherogonal copper-free click chemistry, resulting in the cells being tracked via near-infrared fluorescence (NIRF), magnetic resonance (MR) and computed tomography (CT) imaging without cytotoxicity and functional interference.

Sepulcre article in Nature Medicine

05/05/2019


Dr. Jorge Sepulcre, an Assistant Professor of Radiology at HMS and Assistant in Neuroscience at the MGH Gordon Center, leads a lab that focuses on brain imaging studies aimed at the understanding of large-scale brain networks implicated in human cognition and neurodegenerative disorders.

His article titled “Neurogenetic contributions to amyloid beta and tau spreading in the human cortex.” has been published in Nature Medicine.

Summary:  Tau and beta-amyloid (Aβ) proteins accumulate along neuronal circuits in Alzheimer’s disease (AD). Unraveling the genetic background for the regional vulnerability of these proteinopathies can help understand the mechanisms of pathology progression. To that end, we developed a novel graph theory approach and used it to investigate the intersection of longitudinal Aβ and tau PET imaging of healthy adult individuals and the genetic transcriptome of the Allen Human Brain Atlas. We identified distinctive pathways for tau and Aβ accumulation, of which the tau pathways correlated with cognitive levels. We found that tau- and Aβ-propagation patterns were associated with a common genetic profile related to lipid metabolism, in which APOE played a central role, whereas the tau-specific genetic profile was classified as “axon-related” and the Aβ profile as “dendrite-related”. This is the first study revealing distinct genetic profiles that may confer vulnerability to tau- and Aβ-in-vivo-propagation in the human brain.

Gordon Lecture Series: Identify External Funding Opportunities with Pivot

04/22/2019


The facilitator, Amy Robb is Associate Director for Prospect Research and Funding Opportunities in the Office of Development. Ms. Robb holds a master’s in library and information science from UIUC and a graduate certificate in women’s studies from the George Washington University. Below is a summary of her presentation.

Amy Robb

In this seminar, Ms. Robb taught how to identify external funding opportunities using Pivot – a library database that indexes announcements for grants, fellowships, conferences and equipment acquisition.  The advantage of Pivot is that it contains information about government, philanthropic, industry, and international funding opportunities from across different scientific disciplines. 

Ms. Robb discussed with the audience potential strategies to diversify funding portfolios. She also provided useful tips on searching funding opportunities and configuring funding alerts to provide individualized notification of new funding opportunities.

Dr. Georges El Fakhri Earns Edward J. Hoffman Award

04/04/2019


This story was originally published on 03/12/2019 by Rad Times, a publication of the Mass General Hospital Department of Radiology.

The Edward J. Hoffman Award honors those who have made outstanding contributions to nuclear medicine research and education. The 2019 recipient is Georges El Fakhri, PhD, professor of radiology at Harvard Medical School and Massachusetts General Hospital in Boston, Massachusetts. He is receiving the award for outstanding contributions to quantitative SPECT, PET-CT and PET-MR imaging and to the education of nuclear medicine scientists and physicians.

Dr. Georges El Fakhri was one of twelve scientists and physicians elected Fellow to the Society of Nuclear Medicine and Molecular Imaging for his contributions to quantitative PET, CT and MR imaging during a special plenary session at the society’s 2018 annual meeting in June in Philadelphia. The SNMMI Fellowship was established in 2016 to recognize distinguished service to the society as well as exceptional achievement in the field of nuclear medicine and molecular imaging. It is one of the most prestigious formal recognitions available to longtime SNMMI members.