Zaman Lab



About the lab

PI: Raiyan Zaman

Our mission is to overcome the limitation of the currently available clinical imaging systems for detection of coronary artery disease (CAD).


Research

My laboratory's research focus involves the design and development of cutting-edge imaging multi-mode imaging system to overcome currently available clinical imaging systems.  Our goal is to early detection of thin-cap-fibro-theroma (TCFA) the underlying causes of coronary artery disease. We further characterize the TCFA by identifying disease compositions and their progression over time to unravel this complex human disease, one of the leading causes of morbidity. By integrating optical, phoacoustic, radioluminescence we focuse to get the precise location of TCFA and its compositions. Our work seeks to better understand the disease mechanisms, progression. We are dissecting the role of TCFA perturbations on vascular wall processes during atherosclerosis progression. We are also studying novel molecular imaging methods to study this deadly disease in subcellular level to further inform translational targeting of TCFA.


In vivo aorta images of WHHL rabbit. CRI images at PSE identified TCFA with high RL signal associated to macrophages accumulation (*wall-thickness65 µm) The OCT and histology images showed similar results.

In vivo aorta images of WHHL rabbit. CRI images at PSE identified TCFA with high RL signal associated to macrophages accumulation (*wall-thickness<65 µm). No RL signal from non-TCFA (#wall-thickness>65 µm) The OCT and histology images showed similar results. [Zaman el al.].

 In vivo aorta images of WHHL rabbit. PAT images at PSE highlighted phospholipids and cholesterol as cholesterol cleft in histology. Elastin fiber and collagen (1180 nm) were also detected and verified with histology. OCT verified the presence of lipid from low signal attenuation within TCFA

In vivo aorta images of WHHL rabbit. PAT images at PSE highlighted phospholipids and cholesterol as cholesterol cleft in histology. Elastin fiber and collagen (1180 nm) were also detected and verified with histology. OCT verified the presence of lipid from low signal attenuation within TCFA [Zaman el al.].

PA signals from human carotid arterial plaques represented calcification (540/560 nm), cholesterol (1210 nm), collagen/elastin (1180) that correlated with (i) Trichrome, (ii) EVG stained histology

PA signals from human carotid arterial plaques represented calcification (540/560 nm), cholesterol (1210 nm), collagen/elastin (1180) that correlated with (i) Trichrome, (ii) EVG stained histology [Zaman et al.].

Members

Faculty

    Fellows

      Students

        Research Assistants

          PI: Raiyan Zaman
          Currently recruiting for a postdoctoral position

          Selected Publications

          1. Raiyan T. Zaman, Bo Chen, Ashwin B. Parthasarathy, Arnold D. Estrada Jr, Ardien Ponticorvo, Henry G. Rylander III, Andrew K. Dunn, Ashley J. Welch, “Enhancement of Light in Tissue using Hyper-osmotic Agents” 6854-54, Dec. 2007.
          2. Raiyan T. Zaman, Parmeswaran Diagaradjane, James Wong, Jon Schwartz, Narasimhan Rajaram, Henry G. Rylander III, Sunil Krishnan, James W. Tunnell, “In Vivo Detection of Gold Nanoshells in Tumors Using Diffuse Optical Spectroscopy,” IEEE Journal of Selected Topics in Quantum Electronics, Vol. 13(6):1715–1720, November/December 2007.
          3. Bo Chen, Jeffrey Oliver, Rebecca Vincelette, Ginger Pocock, Raiyan Zaman, Ashley J. Welch, “Porcine Skin ED50 Damage Thresholds for 1214 nm Laser Irradiation,” 6854, Optical Interactions with Tissue and Cells XIX, Jan. 2008.
          4. Raiyan T. Zaman, Henry G. Rylander III, Narasimhan Rajaram, Tianyi Wang, Nitin Asokan, James W. Tunnell, Ashley J. Welch, ” Changes in Morphology and Optical Properties of Sclera due to Hyperosmotic agent” 7175-11, Dec. 2008.
          5. Raiyan T. Zaman, Ashwin B. Parthasarathy, Gracie Vargas, Bo Chen, Andrew Dunn, Henry G. Rylander III, Ashley J. Welch, “Perfusion in skin Treated with Glycerol,” Journal of Lasers in Surgery and Medicine, Vol. 41(7):492–503, September 2009.
          6. Raiyan T. Zaman, Narasimhan Rajaram, Alex Walsh, Jeffrey Oliver, Henry G. Rylander III, James W. Tunnell, Ashley J. Welch, Anita Mahadevan-Jansen, “Variation of Fluorescence in Tissue with Temperature,” Journal of Lasers in Surgery and Medicine, Vol. 43(1):36–42, January 2011.
          7. Raiyan T. Zaman, Henry G. Rylander III, Narasimhan Rajaram, Tianyi Wang, Brandon S. Nichols, James W. Tunnell, Ashley J. Welch, “Changes in Morphology and Optical Properties of Sclera and Choroidal Layers due to Hyperosmotic Agent,” Journal of Biomedical Optics, Vol. 16(7):1–13, July 2011.
          8. Raiyan T. Zaman, Ashwini Gopal, Kathryn Starr, Xiaojing Zhang, Sharon Thomsen, James W. Tunnell, Ashley J. Welch, Henry G. Rylander, “Light Activated Micro-Patterned Drug Delivery Device for Light-activated Drug Release,” Journal of Lasers in Surgery and Medicine, Vol. 44(1):30–48, January 2012.
          9. Raiyan T. Zaman, Hisanori Kosuge, Guillem Pratx, Colin Carpenter, Lei Xing, Michael V. McConnell, “Fiber-Optic System for Dual-Modality Imaging of Glucose Probes 18F-FDG and 6-NBDG in Atherosclerotic Plaques,” PloS One, PONE-D-14-17270R1 10.1371/journal.pone.0108108, September 2014.
          10. Raiyan T. Zaman, Hisanori Kosuge, Colin Carpenter, Conroy Sun, Michael V. McConnell, Lei Xing, “Scintillating-Balloon-Enabled Fiber-Optic System for Radionuclide Imaging of Atherosclerotic Plaques,” Journal of Nuclear Medicine, doi:10.2967/jnumed.114.153239, Vol. 56(5):771-777, May, 2015.
          11. Raiyan T. Zaman, Silvan Tuerkcan, Morteza Mahmoudi, Toshinobu Saito, Hisanori Kosuge, Phillip C. Yang, Frederick T. Chin, Michael V. McConnell, Lei Xing, “Imaging Cellular Pharmacokinetics of 18F-FDG and 6-NBDG in Inflammatory/Stem Cells,” Plos One, PONE-D-17-40351R1/10.1371/journal.pone.0192662, February 2018.
          12. Raiyan T. Zaman, Siavash Yousefi, Steven R. Long, Toshinobu Saito, Michael Mandella, Zhen Qiu, Ruimin Chen, Christopher H. Contag, Sanjiv S. Gambhir, Frederick T. Chin, Butras T. Khuri-Yakub, Michael V. McConnell, K. Kirk Shung, Lei Xing, “A Dual-Modality Hybrid Imaging System Harnesses Radioluminescence and Sound to Reveal Molecular Pathology of Atherosclerotic Plaques,” Nature Scientific Reports, www.nature.com/articles/s41598-018-26696-8, June 2018.
          13. Raiyan T. Zaman, Siavash Yousefi, Hidetoshi Chibana, Fumiaki Ikeno, Steven R. Long, Sanjiv S. Gambhir, Frederick T. Chin, Michael V. McConnell, Lei Xing, Alan Yeung, “In Vivo Translation of the CIRPI System—Revealing Molecular Pathology of Rabbit Aortic Atherosclerotic Plaques,” Journal of Nuclear Medicine, DOI:2967/jnumed.118.222471, February 2019.

          Collaborators

          Joseph Wu, MD, PhD, Stanford University School of Medicine
          Sanjiv Sam Gambihir, MD. PhD, Stanford University School of Medicine
          Roger D. Kornberg, PhD, Stanford University School of Medicine
          Maya Azubel, PhD, Stanford University School of Medicine
          Bahman Anvari, PhD, University of California, Riverside
          Moses Wilkies, PhD, Harvard Medical School

          Funding sources

          NIH 3R00HL127180 (NHLBI)
          PI: Raiyan T. Zaman
          NIH Pathway To Independence Award (R00 phase)
          Title: A Novel Intravascular CRI-PAT Imaging System to Characterize Vulnerable Plaque.
          Goal: Characterize coronary plaque using a dual-modality catheter based optical imaging system.

          Contact us

          Imaging Research Fellow The Gordon Center for Medical Imaging in the Department of Radiology at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) in Boston, Massachusetts has an opening for qualified individuals at the post-doctoral level to work on research related to design and development of novel catheter based cardiac imaging systems. The Department of Radiology at MGH is equipped with the first mobile PET/CT, the first brain PET/MRI, and the first whole-body PET/MRI in the United States. It is also equipped with SPECT/CT, and a substantial large scale shared memory computing facility for computationally intensive research applications. Applicants must have obtained or anticipate receiving a Ph.D. in next 3 months in Applied Physics or Biomedical Engineering or other related disciplines. It is required for applicants to have strong hands on experience in design and development of imaging system in cardiac application specifically photoacoustic tomography, optic based catheter system. Also, the candidate should have strong analytical, quantitative, programming (Matlab, Lab view), signal/image processing skills as well as strong motivation to learn new research methods. Previous experience in medical imaging system development is preferred. The successful candidate will have joint appointments at MGH and HMS. If interested, please send your CV, letter describing interests, background, qualifications, and recent publications in imaging field (especially photoacoustic tomography and optics) in one PDF file electronically to the following email address.

          Dr. Raiyan T. Zaman Gordon Center for Medical Imaging,
          MGH Radiology Department
          149, 13th Street, Room 5.410
          Charlestown, MA 02129
          Emails: rzaman@mgh.harvard.edu

          MGH & HMS are equal-opportunity, affirmative action employers. Women and minority candidates are strongly encouraged to apply.