Sepulcre Lab

About the lab

PI: Jorge Sepulcre

The Sepulcre lab focuses on brain imaging studies aiming at the understanding of large-scale brain networks implicated in human cognition and neurodegenerative disorders. We also devote a substantial part of our work developing cutting-edge network methodologies for different brain imaging modalities such as functional connectivity MRI and PET imaging.


Our specific research interest aligns with the following topics:

  • Systems Neuroscience
  • Brain Functional Streams
  • Brain Hierarchical Organization
  • Multimodal Sensory Integration
  • Language Neuroarchitecture
  • Neurodegenerative Disorders
Link to research page.



    Research Assistants

      Research Fellows:
      Laura Ortiz-Teran
      Ibai Diez Palacio


      Selected Publications


      • Ortiz-Teran L, Ortiz T, Perez DL, Aragon JI, Diez I, Pascual-Leone A, Sepulcre J. Brain Plasticity in Blind Subjects Centralizes Beyond the Modal Cortices. Front Syst Neurosci 2016; 10():61
      • Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. J. Neurosci. 2016; 36(28):7364-74
      • Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann. Neurol. 2016; 79(1):110-9
      • Hu C, Sepulcre J, Johnson KA, Fakhri GE, Lu YM, Li Q. Matched signal detection on graphs: Theory and application to brain imaging data classification. Neuroimage 2016; 125():587-600
      • Sepulcre J, Masdeu JC. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease. Methods Mol. Biol. 2016; 1303():509-19
      • Sepulcre J. An OP4 functional stream in the language-related neuroarchitecture. Cereb. Cortex 2015; 25(3):658-66
      • Sepulcre J. Functional streams and cortical integration in the human brain. Neuroscientist. 2014 Oct; 20(5):499-508.
      • Sepulcre J. Integration of visual and motor functional streams in the human brain. Neuroscience Letters. 2014 May 1; 567:68-73.

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