About the lab
PI: Hamid Sabet
Research activities in Sabet Lab fall into the category of radiation physics and instrumentation that span over many areas of medical and non-medical applications. These projects mainly fit into development of high-performance and advanced radiation detectors by rigorously studying and addressing fundamental limitations of current radiation detector systems. Current research include fabrication of high-performance scintillation detectors using laser-induced optical barriers (LIOB) technique, light transport simulation in crystals, detector-, and system-level modeling of radiation detectors, and system integration and characterization. Developing high-performance cardiac SPECT system, novel brain and small animal PET systems, photon counting CT detector system, and multimodality intraoperative imaging system are the current active projects.
Laser Processed Scintillators
Light transport simulations for detector performance evaluation
Performance comparison of laser processed LIOB:Ce with mechanically pixelated/monolithic scintillators. [Publication]
Comparison of the characteristics of the four detector categories. The Mechanical array and the all-way barrier patterns were simulated with a 1 mm thick light guide (RI=1.5). A, C, and D show the results for polished crystal/pixels for the mechanical array and the monolithic crystal, and barrier RI=1.0 and interface roughness characterized by σα=20° for the laser-processed detectors. A: LRF for four adjacent MPPC pixels under a beam scan through the center of the detector. B: FWHM of the LRF, for a central MPPC pixel, as a function of DOI and the characteristics of the optical barriers in the case of laser-processed detectors, and surface roughness of the crystal/pixels in the case of the mechanical array and the monolithic crystal. The error bars correspond to the 95% confidence interval of the fitting parameter. C: Flood maps showing the sum of 7 (8 in the case of half- way barriers) discrete interaction depths. D: Line profiles through a central and an edge row in the above flood maps. For the monolithic detector and the half way barriers the depth dependence of the flood map is large making the line profiles not illustrative.
Dynamic Cardiac SPECT
A stationary SPECT system for dynamic cardiac imaging applications
Scintillator-based photon counting CT detector
In scintillator-based photon counting CT detector, scintillator pixels and photodetector pixels are coupled one to one. This is necessary to achieve high light collection efficiency, high light confinement, and hence high SNR. The bottle neck is to fabricate scintillator pixels with small cross-section. Shown in the figure is 1.5 mm thick LYSO:Ce crystal processed with the LIOB technique with various pixel size.
- Sajedi S, Sabet H, Choi HS. Intraoperative biophotonic imaging systems for image-guided interventions. Nanophotonics 2019; 8(1):99-116
View in: PubMed
- Bläckberg L, Sajedi S, Mandl S, Mohan A, Vittum B, El Fakhri G, Sabet H. Exploring light confinement in laser-processed LYSO:Ce for photon counting CT application. Phys Med Biol 2019; 64(9):095020
View in: PubMed
- Lisa Bläckberg, Michael Moebius, Narjes Moghadam, Dilber Uzun-Ozsahin, Eric Mazur, Georges El Fakhri, and Hamid Sabet. 10/29/2016. “Scintillator-based Photon Counting Detector: is it feasible?” Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD), 10/29/2016. IEEE
View in: IEEE library
- P Sheikhzadeh, H Sabet, H Ghadiri, P Geramifar, P Ghafarian, and MR Ay. 7/9/2018. “Concept design and Monte Carlo performance evaluation of HeadphonePET: a novel brain-dedicated PET system based on partial cylindrical detectors.” Journal of Instrumentation, 13, 07, Pp. P07008
View in: Journal of Instrumentation
- Salar Sajedi, Navid Zeraatkar, Mohsen Taheri, Sanaz Kaviani, Hadi Khanmohammadi, Saeed Sarkar, Hamid Sabet, and Mohammad Reza Ay. 3/14/2018. “Generic high resolution PET detector block using 12× 12 SiPM array.” Biomedical Physics & Engineering Express, 4, 3, Pp. 035014.
View in: Biomedical Physics & Engineering Express
- Uzun D Ozsahin, Lisa Bläckberg, G El Fakhri, and H Sabet. 1/30/2017. “GATE simulation of a new design of pinhole SPECT system for small animal brain imaging.” Journal of Instrumentation, 12, 01, Pp. C01085
View in: Journal of Instrumentation
- Hamid Sabet, Brendan C Stack, and Vivek V Nagarkar. 2015. “A hand-held, intra-operative positron imaging probe for surgical applications.” IEEE Transactions on Nuclear Science, 62, 5, Pp. 1927-1934
View in: IEEE TNS
Bläckberg L, Moebius M, El Fakhri G, Mazur E, Sabet H. Light Spread Manipulation in Scintillators Using Laser Induced Optical Barriers. IEEE Trans Nuc. Sci. 2018; 65(8)View in: IEEE TNS
Sheikhzadeh P, Sabet H, Ghadiri H, Geramifar P, Mahani H, Ghafarian P, Ay MR. Development and validation of an accurate GATE model for NeuroPET scanner. Phys Med 2017; 40():59-65
Bläckberg L, El Fakhri G, Sabet H. Simulation study of light transport in laser-processed LYSO:Ce detectors with single-side readout. Phys Med Biol 2017; 62(21):8419-8440
Kaviani S, Zeraatkar N, Sajedi S, Akbarzadeh A, Gorjizadeh N, Farahani MH, Teimourian B, Ghafarian P, Sabet H, Ay MR. Design and development of a dedicated portable gamma camera system for intra-operative imaging. Phys Med 2016; 32(7):889-97
Sabet H, Bläckberg L, Uzun-Ozsahin D, El-Fakhri G. Novel laser-processed CsI:Tl detector for SPECT. Med Phys 2016; 43(5):2630
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