Papisov Lab

About the lab

PI: Mikhail Papisov

The Papisov lab focuses on the following research topics: investigation of in vivo transport processes, development and characterization of macromolecular and supramolecular therapeutics, novel biomaterials, and drug delivery to cancer and central nervous system.


Our research is focused on identifying novel aspects of the in vivo transport mechanisms and, when such aspects are identified, designing macromolecular therapeutic constructs optimized to "ride" on these novel mechanisms to their respective targets. When necessary, the drug development studies include research on relevant factors, such as macromolecule/particle interactions with biological milieu, surface modification (steric protection) and developing new biomaterials and drug release systems.

Dr. Mikhail Papisov has a broad background in macromolecular drug development, with specific training and expertise in chemistry, drug delivery, drug targeting and pharmacology of large molecules and nanoparticles. Two drugs in the development of which the Papisov lab has participated are presently in clinical trials. XMT-1001, a macromolecular tecan, was developed entirely in the laboratory with intention to deliver a highly hydrophobic derivative of camptothecin to tumors that have low vascular permeability. XMT-1107 combines an antiangiogenic functionality developed by Dr. J. Folkman with a new macromolecular platform developed in my laboratory.

Presently, our work is focused on non-invasive investigation of the solute transport processes mediated by the cerebrospinal fluid. We have found that at least three aspects of the cerebrospinal transport were previously not adequately understood, and our findings open a new opportunity to develop cancer therapeutics targeted to meningeal and CNS cancer through cerebrospinal delivery route in spite of the known inefficiency of this route for conventional therapeutics.

Link to research page.




      Research Assistants

        Principal Investigator:
        Dr. Mikhail Papisov

        Assistant in Physics/Instructor:
        Vasily Belov

        Selected Publications

        • Papisov MI, Belov VV, Gannon KS. Physiology of the intrathecal bolus: the leptomeningeal route for macromolecule and particle delivery to CNS. Mol Pharm 2013; 10:1522-32. PubMed
        • Mushti C, Papisov MI. Radioiodination of aryl-alkyl cyclic sulfates. Molecules 2012; 17:13266-74. PubMed
        • Belov VV, Bonab AA, Fischman AJ, Heartlein M, Calias P, Papisov MI. Iodine-124 as a label for pharmacological PET imaging. Mol Pharm 2011; 8:736-47. PubMed

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