Normandin Lab

About the lab

PI: Marc D. Normandin

This page is currently under development

The Normandin lab specializes in kinetic modeling of PET tracers using simultaneous PET/MR for quantitative brain function analysis. They also work on the development of nanoprobes for fluorescence and SPECT imaging as a step towards development of nanomedicines.

Research

• Compartment Modeling of Tracer Pharmacokinetics
• Dopamine Release for Functional Evaluation
• Kinetic Modeling of Monocyte trafficking
• Software Development for Quantitative Image Analysis
• Cognitive Activation Studies using Positron Emission Tomography

Link to research page.

Members

Selected Publications

• Guehl NJ, Dhaynaut M, Hanseeuw BJ, Moon SH, Lois C, Thibault E, Fu JF, Price JC, Johnson KA, El Fakhri G, Normandin MD. Measurement of Cerebral Perfusion Indices from the Early Phase of [F]MK6240 Dynamic Tau PET Imaging. J Nucl Med 2023 ():
• Brugarolas P, Wilks MQ, Noel J, Kaiser JA, Vesper DR, Ramos-Torres KM, Guehl NJ, Macdonald-Soccorso MT, Sun Y, Rice PA, Yokell DL, Lim R, Normandin MD, El Fakhri G. Human biodistribution and radiation dosimetry of the demyelination tracer [F]3F4AP. Eur J Nucl Med Mol Imaging 2023 50 (2):344-351
• Sun Y, Guehl NJ, Zhou YP, Takahashi K, Belov V, Dhaynaut M, Moon SH, El Fakhri G, Normandin MD, Brugarolas P. Radiochemical Synthesis and Evaluation of 3-[C]Methyl-4-aminopyridine in Rodents and Nonhuman Primates for Imaging Potassium Channels in the CNS. ACS Chem Neurosci 2022 ():
• Yuan G, Guehl NJ, Zheng B, Qu X, Moon SH, Dhaynaut M, Shoup TM, Afshar S, Kang HJ, Zhang Z, El Fakhri G, Normandin MD, Brownell AL. Synthesis and Characterization of [F]JNJ-46356479 as the First F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2. Mol Imaging Biol 2021 23 (4):527-536
• Guehl NJ, Neelamegam R, Zhou YP, Moon SH, Dhaynaut M, El Fakhri G, Normandin MD, Brugarolas P. Radiochemical Synthesis and Evaluation in Non-Human Primates of 3-[C]methoxy-4-aminopyridine: A Novel PET Tracer for Imaging Potassium Channels in the CNS. ACS Chem Neurosci 2021 12 (4):756-765
• Pelletier-Galarneau M, Petibon Y, Ma C, Han P, Kim SJW, Detmer FJ, Yokell D, Guehl N, Normandin M, El Fakhri G, Alpert NM. In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study. Eur J Nucl Med Mol Imaging 2021 48 (2):414-420
• Guehl NJ, Ramos-Torres KM, Linnman C, Moon SH, Dhaynaut M, Wilks MQ, Han PK, Ma C, Neelamegam R, Zhou YP, Popko B, Correia JA, Reich DS, El Fakhri G, Herscovitch P, Normandin MD, Brugarolas P. Evaluation of the potassium channel tracer [F]3F4AP in rhesus macaques. J Cereb Blood Flow Metab 2020 :271678X20963404
• Alpert NM, Pelletier-Galarneau M, Petibon Y, Normandin MD, El Fakhri G. In vivo quantification of mitochondrial membrane potential. Nature 2020 583 (7815):E17-E18
• Alpert NM, Pelletier-Galarneau M, Kim SJW, Petibon Y, Sun T, Ramos-Torres KM, Normandin MD, El Fakhri G. Imaging of Mitochondrial Depolarization of Myocardium With Positron Emission Tomography and a Proton Gradient Uncoupler. Front Physiol 2020 11 :491
• Petibon Y, Alpert NM, Ouyang J, Pizzagalli DA, Cusin C, Fava M, El Fakhri G, Normandin MD. PET imaging of neurotransmission using direct parametric reconstruction. Neuroimage 2020 221 ():117154
• Guehl NJ, Wooten DW, El Fakhri G, Normandin MD. Reply to: Fitting of late dynamic [F]MK6240 PET scans for in vivo tau quantification. Eur J Nucl Med Mol Imaging 2020 47 (13):2947-2949
• Sung Y, Tetrault MA, Takahashi K, Ouyang J, Pratx G, Fakhri GE, Normandin MD. Dependence of fluorodeoxyglucose (FDG) uptake on cell cycle and dry mass: a single-cell study using a multi-modal radiography platform. Sci Rep 2020 10 (1):4280
• Guehl NJ, Wooten DW, Yokell DL, Moon SH, Dhaynaut M, Katz S, Moody KA, Gharagouzloo C, Kas A, Johnson KA, El Fakhri G, Normandin MD. Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [F]MK6240 in human subjects. Eur J Nucl Med Mol Imaging 2019 46 (10):2099-2111
• Pizzagalli DA, Berretta S, Wooten D, Goer F, Pilobello KT, Kumar P, Murray L, Beltzer M, Boyer-Boiteau A, Alpert N, El Fakhri G, Mechawar N, Vitaliano G, Turecki G, Normandin M. Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder: In Vivo Positron Emission Tomography and Postmortem Evidence. JAMA Psychiatry 2019 76 (8):854-861
• Alpert NM, Guehl N, Ptaszek L, Pelletier-Galarneau M, Ruskin J, Mansour MC, Wooten D, Ma C, Takahashi K, Zhou Y, Shoup TM, Normandin MD, El Fakhri G. Quantitative in vivo mapping of myocardial mitochondrial membrane potential. PLoS ONE 2018; 13(1):e0190968
  View in: PubMed
• Albrecht DS, Normandin MD, Shcherbinin S, Wooten DW, Schwarz AJ, Zürcher NR, Barth VN, Guehl NJ, Akeju O, Atassi N, Veronese M, Turkheimer F, Hooker JM, Loggia ML. Pseudoreference Regions for Glial Imaging withC-PBR28: Investigation in 2 Clinical Cohorts. J. Nucl. Med. 2018; 59(1):107-114
  View in: PubMed
• Guehl NJ, Normandin MD, Wooten DW, Rozen G, Sitek A, Ruskin J, Shoup TM, Ptaszek LM, El Fakhri G, Alpert NM. Single-scan rest/stress imaging: validation in a porcine model withF-Flurpiridaz. Eur. J. Nucl. Med. Mol. Imaging 2017; 44(9):1538-1546
  View in: PubMed
• Petibon Y, Guehl NJ, Reese TG, Ebrahimi B, Normandin MD, Shoup TM, Alpert NM, El Fakhri G, Ouyang J. Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR. Phys Med Biol 2017; 62(2):326-343
  View in: PubMed
• Guehl NJ, Normandin MD, Wooten DW, Rozen G, Ruskin JN, Shoup TM, Woo J, Ptaszek LM, Fakhri GE, Alpert NM. Rapid computation of single PET scan rest-stress myocardial blood flow parametric images by table look up. Med Phys 2017; 44(9):4643-4651
  View in: PubMed
• Yuan H, Wilks MQ, El Fakhri G, Normandin MD, Kaittanis C, Josephson L. Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials. PLoS ONE 2017; 12(2):e0172722
  View in: PubMed
• Wooten DW, Guehl NJ, Verwer EE, Shoup TM, Yokell DL, Zubcevik N, Vasdev N, Zafonte RD, Johnson KA, El Fakhri G, Normandin MD. Pharmacokinetic Evaluation of the Tau PET Radiotracer F-T807 (F-AV-1451) in Human Subjects. J. Nucl. Med. 2017; 58(3):484-491
  View in: PubMed
• Normandin MD, Yuan H, Wilks MQ, Chen HH, Kinsella JM, Cho H, Guehl NJ, Absi-Halabi N, Hosseini SM, El Fakhri G, Sosnovik DE, Josephson L. Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET. Angew. Chem. Int. Ed. Engl. 2015; 54(44):13002-6
  View in: PubMed
• Wilks MQ, Normandin MD, Yuan H, Cho H, Guo Y, Herisson F, Ayata C, Wooten DW, El Fakhri G, Josephson L. Imaging PEG-like nanoprobes in tumor, transient ischemia, and inflammatory disease models. Bioconjug. Chem. 2015; 26(6):1061-9
  View in: PubMed
• Normandin MD, Zheng MQ, Lin KS, Mason NS, Lin SF, Ropchan J, Labaree D, Henry S, Williams WA, Carson RE, Neumeister A, Huang Y. Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: assessment of kinetic analysis methods, test-retest reproducibility, and gender differences. J. Cereb. Blood Flow Metab. 2015; 35(8):1313-22
  View in: PubMed
• Mandeville JB, Sander CYM, Jenkins BG, Hooker JM, Catana C, Vanduffel W, Alpert NM, Rosen BR, Normandin MD. A receptor-based model for dopamine-induced fMRI signal. Neuroimage 2013; 75():46-57
  View in: PubMed
• Normandin MD, Petersen KF, Ding YS, Lin SF, Naik S, Fowles K, Skovronsky DM, Herold KC, McCarthy TJ, Calle RA, Carson RE, Treadway JL, Cline GW. In vivo imaging of endogenous pancreatic β-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET. J. Nucl. Med. 2012; 53(6):908-16
  View in: PubMed
• Normandin MD, Schiffer WK, Morris ED. A linear model for estimation of neurotransmitter response profiles from dynamic PET data. Neuroimage 2012; 59(3):2689-99
  View in: PubMed

Other publications

• Guehl NJ, Pelletier-Galarneau M, Wooten DW, Guerrero JL, Kas A, Normandin MD, Fakhri GE, Alpert NM. Preclinical Validation of a Single-Scan Rest/Stress Imaging Technique for N-Ammonia Positron Emission Tomography Cardiac Perfusion Studies. Circ Cardiovasc Imaging 2020; 13(1):e009407
  View in: PubMed
• Gholami YH, Josephson L, Akam EA, Caravan P, Wilks MQ, Pan XZ, Maschmeyer R, Kolnick A, El Fakhri G, Normandin MD, Kuncic Z, Yuan H. A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes. Int J Nanomedicine 2020; 15():31-47
  View in: PubMed
• Verwer EE, Kavanagh TR, Mischler WJ, Feng Y, Takahashi K, Wang S, Shoup TM, Neelamegam R, Yang J, Guehl NJ, Ran C, Massefski W, Cui Y, El-Chemaly S, Sadow PM, Oldham WM, Kijewski MF, El Fakhri G, Normandin MD, Priolo C. [F]Fluorocholine and [F]fluoroacetate PET as imaging biomarkers to assess phosphatidylcholine and mitochondrial metabolism in preclinical models of TSC and LAM. Clin. Cancer Res. 2018 Dec 1;24(23):5925-5938
  View in: PubMed
• Yuan H, Wilks MQ, Normandin MD, El Fakhri G, Kaittanis C, Josephson L. Heat-induced radiolabeling and fluorescence labeling of Feraheme nanoparticles for PET/SPECT imaging and flow cytometry. Nat Protoc 2018; 13(2):392-412
  View in: PubMed
• Kaiser RH, Treadway MT, Wooten DW, Kumar P, Goer F, Murray L, Beltzer M, Pechtel P, Whitton A, Cohen AL, Alpert NM, El Fakhri G, Normandin MD, Pizzagalli DA. Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation. Cereb. Cortex 2017; ():1-10
  View in: PubMed
• Collier TL, Maresca KP, Normandin MD, Richardson P, McCarthy TJ, Liang SH, Waterhouse RN, Vasdev N. Brain Penetration of the ROS1/ALK Inhibitor Lorlatinib Confirmed by PET. Mol Imaging ; 16():1536012117736669
  View in: PubMed
• Marquié M, Verwer EE, Meltzer AC, Kim SJW, Agüero C, Gonzalez J, Makaretz SJ, Siao Tick Chong M, Ramanan P, Amaral AC, Normandin MD, Vanderburg CR, Gomperts SN, Johnson KA, Frosch MP, Gómez-Isla T. Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson’s case. Acta Neuropathol Commun 2017; 5(1):75
  View in: PubMed
• Sîrbulescu RF, Boehm CK, Soon E, Wilks MQ, Ilieş I, Yuan H, Maxner B, Chronos N, Kaittanis C, Normandin MD, El Fakhri G, Orgill DP, Sluder AE, Poznansky MC. Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions. Wound Repair Regen 2017; 25(5):774-791
  View in: PubMed
• Marquié M, Siao Tick Chong M, Antón-Fernández A, Verwer EE, Sáez-Calveras N, Meltzer AC, Ramanan P, Amaral AC, Gonzalez J, Normandin MD, Frosch MP, Gómez-Isla T. [F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging. Acta Neuropathol. 2017; 134(4):619-628
  View in: PubMed
• Guehl NJ, Normandin MD, Wooten DW, Rozen G, Ruskin JN, Shoup TM, Woo J, Ptaszek LM, Fakhri GE, Alpert NM. Rapid computation of single PET scan rest-stress myocardial blood flow parametric images by table look up. Med Phys 2017; 44(9):4643-4651
  View in: PubMed
• Collier TL, Normandin MD, Stephenson NA, Livni E, Liang SH, Wooten DW, Esfahani SA, Stabin MG, Mahmood U, Chen J, Wang W, Maresca K, Waterhouse RN, El Fakhri G, Richardson P, Vasdev N. Synthesis and preliminary PET imaging ofC andF isotopologues of the ROS1/ALK inhibitor lorlatinib. Nat Commun 2017; 8():15761
  View in: PubMed
• Yuan H, Wilks MQ, El Fakhri G, Normandin MD, Kaittanis C, Josephson L. Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials. PLoS ONE 2017; 12(2):e0172722
  View in: PubMed
• Marquié M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Antón-Fernández A, Klunk WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S, DeVos SL, Oakley DH, Gomperts SN, Growdon JH, Domoto-Reilly K, Lucente D, Dickerson BC, Frosch MP, Hyman BT, Johnson KA, Gómez-Isla T. Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies. Ann. Neurol. 2017; 81(1):117-128
  View in: PubMed
• Liang SH, Chen JM, Normandin MD, Chang JS, Chang GC, Taylor CK, Trapa P, Plummer MS, Para KS, Conn EL, Lopresti-Morrow L, Lanyon LF, Cook JM, Richter KE, Nolan CE, Schachter JB, Janat F, Che Y, Shanmugasundaram V, Lefker BA, Enerson BE, Livni E, Wang L, Guehl NJ, Patnaik D, Wagner FF, Perlis R, Holson EB, Haggarty SJ, El Fakhri G, Kurumbail RG, Vasdev N. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angew. Chem. Int. Ed. Engl. 2016; 55(33):9601-5
  View in: PubMed
• Zhu W, Ouyang J, Rakvongthai Y, Guehl NJ, Wooten DW, El Fakhri G, Normandin MD, Fan Y. A Bayesian spatial temporal mixtures approach to kinetic parametric images in dynamic positron emission tomography. Med Phys 2016; 43(3):1222-34
  View in: PubMed
• Yoder KK, Albrecht DS, Dzemidzic M, Normandin MD, Federici LM, Graves T, Herring CM, Hile KL, Walters JW, Liang T, Plawecki MH, O’Connor S, Kareken DA. Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics. Drug Alcohol Depend 2016; 160():163-9
  View in: PubMed
• Grogg KS, Toole T, Ouyang J, Zhu X, Normandin MD, Li Q, Johnson K, Alpert NM, El Fakhri G. National Electrical Manufacturers Association and Clinical Evaluation of a Novel Brain PET/CT Scanner. J. Nucl. Med. 2016; 57(4):646-52
  View in: PubMed
• Marquié M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, Frosch MP, Hyman BT, Gómez-Isla T. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann. Neurol. 2015; 78(5):787-800
  View in: PubMed
• Grogg K, Alpert NM, Zhu X, Min CH, Testa M, Winey B, Normandin MD, Shih HA, Paganetti H, Bortfeld T, El Fakhri G. Mapping (15)O production rate for proton therapy verification. Int. J. Radiat. Oncol. Biol. Phys. 2015; 92(2):453-9
  View in: PubMed
• Yoder KK, Territo PR, Hutchins GD, Hannestad J, Morris ED, Gallezot JD, Normandin MD, Cosgrove KP. Comparison of standardized uptake values with volume of distribution for quantitation of [(11)C]PBR28 brain uptake. Nucl. Med. Biol. 2015; 42(3):305-8
  View in: PubMed
• Liang SH, Yokell DL, Normandin MD, Rice PA, Jackson RN, Shoup TM, Brady TJ, El Fakhri G, Collier TL, Vasdev N. First human use of a radiopharmaceutical prepared by continuous-flow microfluidic radiofluorination: proof of concept with the tau imaging agent [18F]T807. Mol Imaging 2014; 13():
  View in: PubMed
• Wooten DW, Hillmer AT, Murali D, Barnhart TE, Thio JP, Bajwa AK, Bonab AA, Normandin MD, Schneider ML, Mukherjee J, Christian BT. Initial in vivo PET imaging of 5-HT1A receptors with 3-[(18)F]mefway. Am J Nucl Med Mol Imaging 2014; 4(5):483-9
  View in: PubMed
• Huang C, Ackerman JL, Petibon Y, Normandin MD, Brady TJ, El Fakhri G, Ouyang J. Motion compensation for brain PET imaging using wireless MR active markers in simultaneous PET-MR: phantom and non-human primate studies. Neuroimage 2014; 91():129-37
  View in: PubMed
• Morris ED, Kim SJ, Sullivan JM, Wang S, Normandin MD, Constantinescu CC, Cosgrove KP. Creating dynamic images of short-lived dopamine fluctuations with lp-ntPET: dopamine movies of cigarette smoking. J Vis Exp 2013; (78):
  View in: PubMed
• Sander CY, Hooker JM, Catana C, Normandin MD, Alpert NM, Knudsen GM, Vanduffel W, Rosen BR, Mandeville JB. Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI. Proc. Natl. Acad. Sci. U.S.A. 2013; 110(27):11169-74
  View in: PubMed
• Neumeister A, Normandin MD, Pietrzak RH, Piomelli D, Zheng MQ, Gujarro-Anton A, Potenza MN, Bailey CR, Lin SF, Najafzadeh S, Ropchan J, Henry S, Corsi-Travali S, Carson RE, Huang Y. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. Mol. Psychiatry 2013; 18(9):1034-40
  View in: PubMed
• Mandeville JB, Sander CY, Jenkins BG, Hooker JM, Catana C, Vanduffel W, Alpert NM, Rosen BR, Normandin MD. A receptor-based model for dopamine-induced fMRI signal. Neuroimage 2013; 75():46-57
  View in: PubMed
• Normandin MD, Petersen KF, Ding YS, Lin SF, Naik S, Fowles K, Skovronsky DM, Herold KC, McCarthy TJ, Calle RA, Carson RE, Treadway JL, Cline GW. In vivo imaging of endogenous pancreatic β-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET. J. Nucl. Med. 2012; 53(6):908-16
  View in: PubMed
• Neumeister A, Normandin MD, Murrough JW, Henry S, Bailey CR, Luckenbaugh DA, Tuit K, Zheng MQ, Galatzer-Levy IR, Sinha R, Carson RE, Potenza MN, Huang Y. Positron emission tomography shows elevated cannabinoid CB1 receptor binding in men with alcohol dependence. Alcohol. Clin. Exp. Res. 2012; 36(12):2104-9
  View in: PubMed
• Normandin MD, Koeppe RA, Morris ED. Selection of weighting factors for quantification of PET radioligand binding using simplified reference tissue models with noisy input functions. Phys Med Biol 2012; 57(3):609-29
  View in: PubMed
• Anand A, Barkay G, Dzemidzic M, Albrecht D, Karne H, Zheng QH, Hutchins GD, Normandin MD, Yoder KK. Striatal dopamine transporter availability in unmedicated bipolar disorder. Bipolar Disord 2011; 13(4):406-13
  View in: PubMed
• Normandin MD, Schiffer WK, Morris ED. A linear model for estimation of neurotransmitter response profiles from dynamic PET data. Neuroimage 2012; 59(3):2689-99
  View in: PubMed
• Sullivan JM, Risacher SL, Normandin MD, Yoder KK, Froehlich JC, Morris ED. Imaging of alcohol-induced dopamine release in rats:preliminary findings with [(11) C]raclopride PET. Synapse 2011; 65(9):929-37
  View in: PubMed
• Singhal T, Ding YS, Weinzimmer D, Normandin MD, Labaree D, Ropchan J, Nabulsi N, Lin SF, Skaddan MB, Soeller WC, Huang Y, Carson RE, Treadway JL, Cline GW. Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes. Mol Imaging Biol 2011; 13(5):973-84
  View in: PubMed
• Morris ED, Constantinescu CC, Sullivan JM, Normandin MD, Christopher LA. Noninvasive visualization of human dopamine dynamics from PET images. Neuroimage 2010; 51(1):135-44
  View in: PubMed
• Yoder KK, Morris ED, Constantinescu CC, Cheng TE, Normandin MD, O’Connor SJ, Kareken DA. When what you see isn’t what you get: alcohol cues, alcohol administration, prediction error, and human striatal dopamine. Alcohol. Clin. Exp. Res. 2009; 33(1):139-49
  View in: PubMed
• Cheng TE, Yoder KK, Normandin MD, Risacher SL, Converse AK, Hampel JA, Miller MA, Morris ED. A rat head holder for simultaneous scanning of two rats in small animal PET scanners: design, construction, feasibility testing and kinetic validation. J. Neurosci. Methods 2009; 176(1):24-33
  View in: PubMed
• Constantinescu CC, Yoder KK, Kareken DA, Bouman CA, O’Connor SJ, Normandin MD, Morris ED. Estimation from PET data of transient changes in dopamine concentration induced by alcohol: support for a non-parametric signal estimation method. Phys Med Biol 2008; 53(5):1353-67
  View in: PubMed
• Morris ED, Normandin MD, Schiffer WK. Initial comparison of ntPET with microdialysis measurements of methamphetamine-induced dopamine release in rats: support for estimation of dopamine curves from PET data. Mol Imaging Biol ; 10(2):67-73
  View in: PubMed
• Normandin MD, Morris ED. Estimating neurotransmitter kinetics with ntPET: a simulation study of temporal precision and effects of biased data. Neuroimage 2008; 39(3):1162-79
  View in: PubMed
• Normandin MD, Morris ED. Temporal resolution of ntPET using either arterial or reference region-derived plasma input functions. Conf Proc IEEE Eng Med Biol Soc 2006; 1():2005-8
  View in: PubMed
• Yoder KK, Constantinescu CC, Kareken DA, Normandin MD, Cheng TE, O’Connor SJ, Morris ED. Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study. Alcohol. Clin. Exp. Res. 2007; 31(6):965-73
  View in: PubMed
• Morris ED, Yoder KK, Wang C, Normandin MD, Zheng QH, Mock B, Muzic RF, Froehlich JC. ntPET: a new application of PET imaging for characterizing the kinetics of endogenous neurotransmitter release. Mol Imaging ; 4(4):473-89
  View in: PubMed

Key resources

• GE Discovery PET/CT
• Automated Radiochemical Synthesis systems
• E.cam (Siemens) SPECT Systems and Planar Gamma Cameras
• Exact HR+ Large Bore PET Scanner
• NeuroPET/CT dedicated high sensitivity brain scanner
• PC4096 Large Bore PET Scanner
• Siemens PET/CT Scanner
• Siemens Symbia SPECT/CT
• VISTA small animal micro PET/CT
• Tri-modality MicroPET-SPECT-CT

Funding sources

NIH NIBIB

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