Johnson Lab

About the lab

PI: Keith A. Johnson

We are developing preventive therapies and treatment of Alzheimer’s disease. Recently, we have been investigating imaging agents that can detect tau deposits in the brain related to cognitive impairment. We are exploring ways to use these imaging techniques to detect the risk of developing impairment.

Research

Major research interests include the early diagnosis and treatment monitoring of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and dementia with Lewy bodies.

  • Determine the earliest brain changes that will predict development of memory loss and eventual cognitive decline associated with Alzheimer’s disease
  • Use PET scans to detect an abnormal form of a brain protein known as tau in living humans, and relate tau pathology to age, brain shrinkage, and cognitive impairment

Members

Students

Research Administrator

Ramzi El Fakhri

Selected Publications

  • Jacobs HIL, Augustinack JC, Schultz AP, Hanseeuw BJ, Locascio J, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology 2020; 94(18):e1916-e1928
    View inPubMed
  • Song TA, Yang F, Chowdhury SR, Kim K, Johnson KA, El Fakhri G, Li Q, Dutta J. PET Image Deblurring and Super-Resolution with an MR-Based Joint Entropy Prior. IEEE Trans Comput Imaging 2019; 5(4):530-539
    View inPubMed
  • Guehl NJ, Wooten DW, Yokell DL, Moon SH, Dhaynaut M, Katz S, Moody KA, Gharagouzloo C, Kas A, Johnson KA, El Fakhri G, Normandin MD. Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [F]MK6240 in human subjects. Eur. J. Nucl. Med. Mol. Imaging 2019; 46(10):2099-2111
    View inPubMed
  • Yang F, Roy Chowdhury S, Jacobs HIL, Johnson KA, Dutta J. A longitudinal model for tau aggregation in Alzheimer’s disease based on structural connectivity. Inf Process Med Imaging 2019; 11492:384-393
    View inPubMed
  • Wooten DW, Ortiz-Terán L, Zubcevik N, Zhang X, Huang C, Sepulcre J, Atassi N, Johnson K, Zafonte R, El Fakhri G. Multimodal Signatures of Tau Pathology, Neuronal Fiber Integrity, and Functional Connectivity in Traumatic Brain Injury. J. Neurotrauma 2019; 36(23):3233-3243
    View inPubMed
  • Marshall GA, Gatchel JR, Donovan NJ, Muniz MC, Schultz AP, Becker JA, Chhatwal JP, Hanseeuw BJ, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer’s Disease Dementia. J. Alzheimers Dis. 2019; 67(2):757-768
    View inPubMed
  • Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hanseeuw BJ, Buckley R, Chhatwal J, Hedden T, Marshall GA, Quiroz YT, Donovan NJ, Jackson J, Gatchel JR, Rabin JS, Jacobs H, Yang HS, Properzi M, Kirn DR, Rentz DM, Johnson KA. The impact of amyloid-beta and tau on prospective cognitive decline in older individuals. Ann. Neurol. 2019; 85(2):181-193
    View inPubMed
  • Huijbers W, Schultz AP, Papp KV, LaPoint MR, Hanseeuw B, Chhatwal JP, Hedden T, Johnson KA, Sperling RA. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. J. Neurosci. 2019; 39(3):548-556
    View inPubMed
  • Properzi MJ, Buckley RF, Chhatwal JP, Donohue MC, Lois C, Mormino EC, Johnson KA, Sperling RA, Schultz AP. Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers. Neuroimage 2019; 186:446-454
    View inPubMed
  • Lois C, Gonzalez I, Johnson KA, Price JC. PET imaging of tau protein targets: a methodology perspective. Brain Imaging Behav 2019 Apr;13(2):333-344.
    View in: PubMed
  • Sepulcre J, Grothe MJ, d’Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang HS, Jacobs HIL, Hanseeuw BJ, Li Q, El-Fakhri G, Sperling RA, Johnson KA. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nat. Med. 2018; 24(12):1910-1918
    View inPubMed
  • Hanseeuw BJ, Jonas V, Jackson J, Betensky RA, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Association of anxiety with subcortical amyloidosis in cognitively normal older adults. Mol. Psychiatry 2018;
    View in: PubMed
  • Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vanini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. PET staging of amyloidosis using striatum. Alzheimers Dement 2018; 14(10):1281-1292
    View in: PubMed
  • Lee CM, Jacobs HIL, Marquié M, Becker JA, Andrea NV, Jin DS, Schultz AP, Frosch MP, Gómez-Isla T, Sperling RA, Johnson KA. 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. J. Alzheimers Dis. 2018; 62(4):1691-1702
    View in: PubMed
  • Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat. Neurosci. 2018; 21(3):424-431
    View in: PubMed
  • Quiroz YT, Sperling RA, Norton DJ, Baena A, Arboleda-Velasquez JF, Cosio D, Schultz A, Lapoint M, Guzman-Velez E, Miller JB, Kim LA, Chen K, Tariot PN, Lopera F, Reiman EM, Johnson KA. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA Neurol 2018 May 1;75(5):548-556.
    View in: PubMed
  • Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat. Neurosci. 2018; 21(3):424-431
    View in: PubMed
  • Sepulcre J, Grothe MJ, Sabuncu M, Chhatwal J, Schultz AP, Hanseeuw B, El Fakhri G, Sperling R, Johnson KA. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurol 2017; 74(7):813-820
    View in: PubMed
  • Sepulcre J, Sabuncu MR, Li Q, El Fakhri G, Sperling R, Johnson KA. Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain. Alzheimers Dement 2017; 13(11):1261-1269
    View in: PubMed
  • Hanseeuw BJ, Betensky RA, Schultz AP, Papp KV, Mormino EC, Sepulcre J, Bark JS, Cosio DM, LaPoint M, Chhatwal JP, Rentz DM, Sperling RA, Johnson KA. Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline. Ann. Neurol. 2017; 81(4):583-596
    View in: PubMed
  • Rentz DM, Mormino EC, Papp KV, Betensky RA, Sperling RA, Johnson KA. Cognitive resilience in clinical and preclinical Alzheimer’s disease: the Association of Amyloid and Tau Burden on cognitive performance. Brain Imaging Behav 2017; 11(2):383-390
    View in: PubMed
  • Gomperts SN, Locascio JJ, Makaretz SJ, Schultz A, Caso C, Vasdev N, Sperling R, Growdon JH, Dickerson BC, Johnson K. Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases. JAMA Neurol 2016; 73(11):1334-1341
    View in: PubMed
  • Chhatwal JP, Schultz AP, Marshall GA, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe AD, Hyman BT, Sperling RA, Johnson KA. Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly. Neurology 2016; 87(9):920-6
    View in: PubMed
  • Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann. Neurol. 2016; 79(1):110-9
    View in: PubMed
  • Hanseeuw BJ, Schultz AP, Betensky RA, Sperling RA, Johnson KA. Decreased hippocampal metabolism in high-amyloid mild cognitive impairment. Alzheimers Dement 2016; 12(12):1288-1296
    View in: PubMed
  • Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. J. Neurosci. 2016; 36(28):7364-74
    View in: PubMed
  • Maye JE, Betensky RA, Gidicsin CM, Locascio J, Becker JA, Pepin L, Carmasin J, Rentz DM, Marshall GA, Blacker D, Sperling RA, Johnson KA. Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring. Neurobiol. Aging 2016; 40():61-67
    View in: PubMed
  • Greve DN, Salat DH, Bowen SL, Izquierdo-Garcia D, Schultz AP, Catana C, Becker JA, Svarer C, Knudsen GM, Sperling RA, Johnson KA. Different partial volume correction methods lead to different conclusions: An (18)F-FDG-PET study of aging. Neuroimage 2016; 132():334-343
    View in: PubMed
  • Gidicsin CM, Maye JE, Locascio JJ, Pepin LC, Philiossaint M, Becker JA, Younger AP, Dekhtyar M, Schultz AP, Amariglio RE, Marshall GA, Rentz DM, Hedden T, Sperling RA, Johnson KA. Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers. Neurology 2015; 85(1):48-55
    View in: PubMed
  • Sperling R, Mormino E, Johnson K. The evolution of preclinical Alzheimer’s disease: implications for prevention trials. Neuron 2014; 84(3):608-22
    View in: PubMed
  • Sepulcre J, Sabuncu MR, Becker A, Sperling R, Johnson KA. In vivo characterization of the early states of the amyloid-beta network. Brain 2013; 136(Pt 7):2239-52
    View in: PubMed
  • Sperling RA, Karlawish J, Johnson KA. Preclinical Alzheimer disease-the challenges ahead. Nat Rev Neurol 2013; 9(1):54-8
    View in: PubMed
  • Johnson KA, Sperling RA, Sepulcre J. Functional connectivity in Alzheimer’s disease: measurement and meaning. Biol. Psychiatry 2013; 74(5):318-9
    View in: PubMed
  • Johnson KA, Sperling RA, Gidicsin CM, Carmasin JS, Maye JE, Coleman RE, Reiman EM, Sabbagh MN, Sadowsky CH, Fleisher AS, Murali Doraiswamy P, Carpenter AP, Clark CM, Joshi AD, Lu M, Grundman M, Mintun MA, Pontecorvo MJ, Skovronsky DM, . Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer’s disease dementia, mild cognitive impairment, and normal aging. Alzheimers Dement 2013; 9(5 Suppl):S72-83
    View in: PubMed
  • Johnson KA, Minoshima S, Bohnen NI, Donohoe KJ, Foster NL, Herscovitch P, Karlawish JH, Rowe CC, Carrillo MC, Hartley DM, Hedrick S, Pappas V, Thies WH, , , . Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer’s Association. Alzheimers Dement 2013; 9(1):e-1-16
    View in: PubMed
  • Johnson KA, Minoshima S, Bohnen NI, Donohoe KJ, Foster NL, Herscovitch P, Karlawish JH, Rowe CC, Carrillo MC, Hartley DM, Hedrick S, Pappas V, Thies WH. Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer’s Association. J. Nucl. Med. 2013; 54(3):476-90
    View in: PubMed
  • Sepulcre J, Sabuncu MR, Yeo TB, Liu H, Johnson KA. Stepwise connectivity of the modal cortex reveals the multimodal organization of the human brain. J. Neurosci. 2012; 32(31):10649-61
    View in: PubMed
  • Sepulcre J, Sabuncu MR, Johnson KA. Network assemblies in the functional brain. Curr. Opin. Neurol. 2012; 25(4):384-91
    View in: PubMed
  • Sperling RA, Johnson KA. Dementia: new criteria but no new treatments. Lancet Neurol 2012; 11(1):4-5
    View in: PubMed
  • Marshall GA, Olson LE, Frey MT, Maye J, Becker JA, Rentz DM, Sperling RA, Johnson KA. Instrumental activities of daily living impairment is associated with increased amyloid burden. Dement Geriatr Cogn Disord 2011; 31(6):443-50
    View in: PubMed
  • Becker JA, Hedden T, Carmasin J, Maye J, Rentz DM, Putcha D, Fischl B, Greve DN, Marshall GA, Salloway S, Marks D, Buckner RL, Sperling RA, Johnson KA. Amyloid-β associated cortical thinning in clinically normal elderly. Ann. Neurol. 2011; 69(6):1032-42
    View in: PubMed
  • Rentz DM, Locascio JJ, Becker JA, Moran EK, Eng E, Buckner RL, Sperling RA, Johnson KA. Cognition, reserve, and amyloid deposition in normal aging. Ann. Neurol. 2010; 67(3):353-64
    View in: PubMed

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