El Fakhri Lab



About the lab

PI: Georges El Fakhri

The El Fakhri lab focuses on a variety of subjects including kinetic modeling of neurotransmission, cardiac perfusion and mitochondrial function, simultaneous PET-MR imaging, in-room PET-CT monitoring of proton therapy, high sensitivity/resolution brain imaging, quantitative dual tracer PET-CT and SPECT-CT, and objective assessment of image quality for estimation and detection tasks.


Selected Publications

  • Alpert NM, Guehl N, Ptaszek L, Pelletier-Galarneau M, Ruskin J, Mansour MC, Wooten D, Ma C, Takahashi K, Zhou Y, Shoup TM, Normandin MD, El Fakhri G. Quantitative in vivo mapping of myocardial mitochondrial membrane potential. PLoS ONE 2018; 13(1):e0190968
    View in: PubMed
  • Fahey FH, Grogg K, El Fakhri G. Use of Monte Carlo Techniques in Nuclear Medicine. J Am Coll Radiol 2018; 15(3 Pt A):446-448
    View in: PubMed
  • Han PK, Ma C, Deng K, Hu S, Jee KW, Ying K, Chen YL, El Fakhri G. A minimum-phase Shinnar-Le Roux spectral-spatial excitation RF pulse for simultaneous water and lipid suppression inH-MRSI of body extremities. Magn Reson Imaging 2018; 45():18-25
    View in: PubMed
  • Rakvongthai Y, El Fakhri G. Magnetic Resonance-based Motion Correction for Quantitative PET in Simultaneous PET-MR Imaging. PET Clin 2017; 12(3):321-327
    View in: PubMed
  • Li Q, Li H, Kim K, El Fakhri G. Joint estimation of activity image and attenuation sinogram using time-of-flight positron emission tomography data consistency condition filtering. J Med Imaging (Bellingham) 2017; 4(2):023502
    View in: PubMed
  • Cho J, Grogg K, Min CH, Zhu X, Paganetti H, Lee HC, El Fakhri G. Feasibility study of using fall-off gradients of early and late PET scans for proton range verification. Med Phys 2017; 44(5):1734-1746
    View in: PubMed
  • Neelamegam R, Yokell DL, Rice PA, Furumoto S, Kudo Y, Okamura N, El Fakhri G. A report of the automated radiosynthesis of the tau positron emission tomography radiopharmaceutical, [F]-THK-5351. J Labelled Comp Radiopharm 2017; 60(2):140-146
    View in: PubMed
  • Sabet H, Bläckberg L, Uzun-Ozsahin D, El-Fakhri G. Novel laser-processed CsI:Tl detector for SPECT. Med Phys 2016; 43(5):2630
    View in: PubMed
  • Bian J, Sharp GC, Park YK, Ouyang J, Bortfeld T, El Fakhri G. Investigation of cone-beam CT image quality trade-off for image-guided radiation therapy. Phys Med Biol 2016; 61(9):3317-46
    View in: PubMed
  • Grogg KS, Toole T, Ouyang J, Zhu X, Normandin MD, Li Q, Johnson K, Alpert NM, El Fakhri G. National Electrical Manufacturers Association and Clinical Evaluation of a Novel Brain PET/CT Scanner. J. Nucl. Med. 2016; 57(4):646-52
    View in: PubMed
  • Zhang X, Chen YL, Lim R, Huang C, Chebib IA, El Fakhri G. Synergistic role of simultaneous PET/MRI-MRS in soft tissue sarcoma metabolism imaging. Magn Reson Imaging 2016; 34(3):276-9
    View in: PubMed
  • Ouyang J, Petibon Y, Huang C, Reese TG, Kolnick AL, El Fakhri G. Quantitative simultaneous positron emission tomography and magnetic resonance imaging. J Med Imaging (Bellingham) 2014; 1(3):033502
    View in: PubMed
  • Dutta J, Huang C, Li Q, El Fakhri G. Pulmonary imaging using respiratory motion compensated simultaneous PET/MR. Med Phys 2015; 42(7):4227-40
    View in: PubMed
  • Paganetti H, El Fakhri G. Monitoring proton therapy with PET. Br J Radiol 2015; 88(1051):20150173
    View in: PubMed
  • Grogg K, Alpert NM, Zhu X, Min CH, Testa M, Winey B, Normandin MD, Shih HA, Paganetti H, Bortfeld T, El Fakhri G. Mapping (15)O production rate for proton therapy verification. Int. J. Radiat. Oncol. Biol. Phys. 2015; 92(2):453-9
    View in: PubMed
  • Huang C, Petibon Y, Ouyang J, Reese TG, Ahlman MA, Bluemke DA, El Fakhri G. Accelerated acquisition of tagged MRI for cardiac motion correction in simultaneous PET-MR: phantom and patient studies. Med Phys 2015; 42(2):1087-97
    View in: PubMed
  • Lorsakul A, Li Q, Trott CM, Hoog C, Petibon Y, Ouyang J, Laine AF, El Fakhri G. 4D numerical observer for lesion detection in respiratory-gated PET. Med Phys 2014; 41(10):102504
    View in: PubMed
  • Schaefferkoetter J, Ouyang J, Rakvongthai Y, Nappi C, El Fakhri G. Effect of time-of-flight and point spread function modeling on detectability of myocardial defects in PET. Med Phys 2014; 41(6):062502
    View in: PubMed
  • Huang C, Altbach MI, El Fakhri G. Pattern recognition for rapid T2 mapping with stimulated echo compensation. Magn Reson Imaging 2014; 32(7):969-74
    View in: PubMed
  • Petibon Y, Huang C, Ouyang J, Reese TG, Li Q, Syrkina A, Chen YL, El Fakhri G. Relative role of motion and PSF compensation in whole-body oncologic PET-MR imaging. Med Phys 2014; 41(4):042503
    View in: PubMed
  • Zhu X, El Fakhri G. Proton therapy verification with PET imaging. Theranostics 2013; 3(10):731-40
    View in: PubMed
  • Rakvongthai Y, Ouyang J, Guerin B, Li Q, Alpert NM, El Fakhri G. Direct reconstruction of cardiac PET kinetic parametric images using a preconditioned conjugate gradient approach. Med Phys 2013; 40(10):102501
    View in: PubMed
  • Nappi C, El Fakhri G. State of the Art in Cardiac Hybrid Technology: PET/MR. Curr Cardiovasc Imaging Rep 2013; 6(4):338-345
    View in: PubMed
  • Petibon Y, Ouyang J, Zhu X, Huang C, Reese TG, Chun SY, Li Q, El Fakhri G. Cardiac motion compensation and resolution modeling in simultaneous PET-MR: a cardiac lesion detection study. Phys Med Biol 2013; 58(7):2085-102
    View in: PubMed
  • Schaefferkoetter J, Casey M, Townsend D, El Fakhri G. Clinical impact of time-of-flight and point response modeling in PET reconstructions: a lesion detection study. Phys Med Biol 2013; 58(5):1465-78
    View in: PubMed
  • Ouyang J, Li Q, El Fakhri G. Magnetic resonance-based motion correction for positron emission tomography imaging. Semin Nucl Med 2013; 43(1):60-7
    View in: PubMed
  • Alpert N, Dean Fang YH, El Fakhri G. Single-scan rest∕stress imaging (18)F-labeled flow tracers. Med Phys 2012; 39(11):6609-20
    View in: PubMed
  • Chun SY, Reese TG, Ouyang J, Guerin B, Catana C, Zhu X, Alpert NM, El Fakhri G. MRI-based nonrigid motion correction in simultaneous PET/MRI. J. Nucl. Med. 2012; 53(8):1284-91
    View in: PubMed
  • Grogg K, Zhu X, Min CH, Winey B, Bortfeld T, Paganetti H, Shih HA, El Fakhri G. Feasibility of Using Distal Endpoints for In-room PET Range Verification of Proton Therapy. IEEE Trans Nucl Sci 2013; 60(5):3290-3297
    View in: PubMed
  • Zhu X, España S, Daartz J, Liebsch N, Ouyang J, Paganetti H, Bortfeld TR, El Fakhri G. Monitoring proton radiation therapy with in-room PET imaging. Phys Med Biol 2011; 56(13):4041-57
    View in: PubMed
  • Guérin B, El Fakhri G. Novel scatter compensation of list-mode PET data using spatial and energy dependent corrections. IEEE Trans Med Imaging 2011; 30(3):759-73
    View in: PubMed
  • Trott CM, Ouyang J, El Fakhri G. Comparison of simultaneous and sequential SPECT imaging for discrimination tasks in assessment of cardiac defects. Phys Med Biol 2010; 55(22):6897-910
    View in: PubMed
  • Zhu X, Reese TG, Crowley EM, El Fakhri G. Improved MAGIC gel for higher sensitivity and elemental tissue equivalent 3D dosimetry. Med Phys 2010; 37(1):183-8
    View in: PubMed
  • Zhu X, El Fakhri G. Monte Carlo modeling of cascade gamma rays in (86)Y PET imaging: preliminary results. Phys Med Biol 2009; 54(13):4181-93
    View in: PubMed
  • Ouyang J, Zhu X, Trott CM, El Fakhri G. Quantitative simultaneous 99mTc/123I cardiac SPECT using MC-JOSEM. Med Phys 2009; 36(2):602-11
    View in: PubMed
  • Trott CM, El Fakhri G. Sequential and simultaneous dual-isotope brain SPECT: comparison with PET for estimation and discrimination tasks in early Parkinson disease. Med Phys 2008; 35(7):3343-53
    View in: PubMed
  • Zaidi H, El Fakhri G. Is absolute quantification of dopaminergic neurotransmission studies with 123I SPECT ready for clinical use? Eur. J. Nucl. Med. Mol. Imaging 2008; 35(7):1330-3
    View in: PubMed
  • Moore SC, Foley Kijewski M, El Fakhri G. Collimator optimization for detection and quantitation tasks: application to gallium-67 imaging. IEEE Trans Med Imaging 2005; 24(10):1347-56
    View in: PubMed
  • El Fakhri G, Trott CM, Sitek A, Bonab A, Alpert NM. Dual-tracer PET using generalized factor analysis of dynamic sequences. Mol Imaging Biol 2013; 15(6):666-74
    View in: PubMed
  • El Fakhri G, Surti S, Trott CM, Scheuermann J, Karp JS. Improvement in lesion detection with whole-body oncologic time-of-flight PET. J. Nucl. Med. 2011; 52(3):347-53
    View in: PubMed
  • El Fakhri G, Ouyang J. Dual-radionuclide brain SPECT for the differential diagnosis of parkinsonism. Methods Mol. Biol. 2011; 680():237-46
    View in: PubMed
  • El Fakhri G, Kardan A, Sitek A, Dorbala S, Abi-Hatem N, Lahoud Y, Fischman A, Coughlan M, Yasuda T, Di Carli MF. Reproducibility and accuracy of quantitative myocardial blood flow assessment with (82)Rb PET: comparison with (13)N-ammonia PET. J. Nucl. Med. 2009; 50(7):1062-71
    View in: PubMed
  • El Fakhri G, Santos PA, Badawi RD, Holdsworth CH, Van Den Abbeele AD, Kijewski MF. Impact of acquisition geometry, image processing, and patient size on lesion detection in whole-body 18F-FDG PET. J. Nucl. Med. 2007; 48(12):1951-60
    View in: PubMed

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