About the lab
PI: Hak Soo Choi
Dr. Choi’s laboratory focuses on the development of novel contrast agents for tissue- and organ-specific targeting and diagnosis. Of particular interest is “Structure-Inherent Targeting,” where small molecules can be used for targeting, imaging, diagnosis and therapy by specifically visualizing target tissue with high optical properties and by avoiding nonspecific uptake in normal background tissues.
Development of targeted multifunctional nanoprobes for pancreatic neuroendocrine tumors
Pancreatic neuroendocrine tumors cannot be adequately treated using conventional treatments and remain an unanswered health concern. Nanoprobes can provide sensitive and specific imaging of pancreatic neuroendocrine tumors for early diagnosis, site-specific delivery of chemotherapeutic agents, and laparoscopic image-guided surgery.
Wada H, Hyun H, Bao K, Lee JH, El Fakhri G, Choi Y, Choi HS. Multivalent Mannose-Decorated NIR Nanoprobes for Targeting Pan Lymph Nodes. Chem Eng J 2018; 340():51-57
Hu S, Kang H, Baek Y, El Fakhri G, Kuang A, Choi HS. Real-Time Imaging of Brain Tumor for Image-Guided Surgery. Adv Healthc Mater 2018; ():e1800066
Bao K, Lee JH, Kang H, Park GK, El Fakhri G, Choi HS. PSMA-targeted contrast agents for intraoperative imaging of prostate cancer. Chem. Commun. (Camb.) 2017; 53(10):1611-1614
Choi NC, Gainor J, Ackman J, Lim R, Sharp GC, El Fakhri G, Niemierko A. ORAL02.03: Robust Correlation Between Metabolic Response Measured with F-FDG PET Soon After Therapy and Clinical Outcome in Lung Cancer: Topic: Radiation Oncology. J Thorac Oncol 2016; 11(11S):S253-S254
Koo H, Lee JH, Bao K, Wu Y, El Fakhri G, Henary M, Yun SH, Choi HS. Site-Specific In Vivo Bioorthogonal Ligation via Chemical Modulation. Adv Healthc Mater 2016; 5(19):2510-2516
Owens EA, Henary M, El Fakhri G, Choi HS. Tissue-Specific Near-Infrared Fluorescence Imaging. Acc. Chem. Res. 2016; 49(9):1731-40
Ashitate Y, Levitz A, Park MH, Hyun H, Venugopal V, Park G, El Fakhri G, Henary M, Gioux S, Frangioni JV, Choi HS. Endocrine-specific NIR fluorophores for adrenal gland targeting. Chem. Commun. (Camb.) 2016; 52(67):10305-8
Kang H, Gravier J, Bao K, Wada H, Lee JH, Baek Y, El Fakhri G, Gioux S, Rubin BP, Coll JL, Choi HS. Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery. Adv. Mater. Weinheim 2016; 28(37):8162-8168
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