Choi Lab

About the lab

PI: Hak Soo Choi

Dr. Choi’s laboratory focuses on the development of novel contrast agents for tissue- and organ-specific targeting and diagnosis. Of particular interest is “Structure-Inherent Targeting,” where small molecules can be used for targeting, imaging, diagnosis and therapy by specifically visualizing target tissue with high optical properties and by avoiding nonspecific uptake in normal background tissues.

Research

Development of targeted multifunctional nanoprobes for pancreatic neuroendocrine tumors 

Pancreatic neuroendocrine tumors cannot be adequately treated using conventional treatments and remain an unanswered health concern. Nanoprobes can provide sensitive and specific imaging of pancreatic neuroendocrine tumors for early diagnosis, site-specific delivery of chemotherapeutic agents, and laparoscopic image-guided surgery.

Members

Students

    Research Assistants

      Selected Publications

      • Wada H, Hyun H, Bao K, Lee JH, El Fakhri G, Choi Y, Choi HS. Multivalent Mannose-Decorated NIR Nanoprobes for Targeting Pan Lymph Nodes. Chem Eng J 2018; 340():51-57
        View in: PubMed
      • Hu S, Kang H, Baek Y, El Fakhri G, Kuang A, Choi HS. Real-Time Imaging of Brain Tumor for Image-Guided Surgery. Adv Healthc Mater 2018; ():e1800066
        View in: PubMed
      • Bao K, Lee JH, Kang H, Park GK, El Fakhri G, Choi HS. PSMA-targeted contrast agents for intraoperative imaging of prostate cancer. Chem. Commun. (Camb.) 2017; 53(10):1611-1614
        View in: PubMed
      • Choi NC, Gainor J, Ackman J, Lim R, Sharp GC, El Fakhri G, Niemierko A. ORAL02.03: Robust Correlation Between Metabolic Response Measured with F-FDG PET Soon After Therapy and Clinical Outcome in Lung Cancer: Topic: Radiation Oncology. J Thorac Oncol 2016; 11(11S):S253-S254
        View in: PubMed
      • Koo H, Lee JH, Bao K, Wu Y, El Fakhri G, Henary M, Yun SH, Choi HS. Site-Specific In Vivo Bioorthogonal Ligation via Chemical Modulation. Adv Healthc Mater 2016; 5(19):2510-2516
        View in: PubMed
      • Owens EA, Henary M, El Fakhri G, Choi HS. Tissue-Specific Near-Infrared Fluorescence Imaging. Acc. Chem. Res. 2016; 49(9):1731-40
        View in: PubMed
      • Ashitate Y, Levitz A, Park MH, Hyun H, Venugopal V, Park G, El Fakhri G, Henary M, Gioux S, Frangioni JV, Choi HS. Endocrine-specific NIR fluorophores for adrenal gland targeting. Chem. Commun. (Camb.) 2016; 52(67):10305-8
        View in: PubMed
      • Kang H, Gravier J, Bao K, Wada H, Lee JH, Baek Y, El Fakhri G, Gioux S, Rubin BP, Coll JL, Choi HS. Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery. Adv. Mater. Weinheim 2016; 28(37):8162-8168
        View in: PubMed

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