PET Imaging of Human Subjects, and Large and Small Animals



The MGH Gordon PET Core provides investigators with required personnel, equipment, and services to design and conduct research studies using positron emission tomography.

Our services include:
  • Synthesis of radiotracers and radiopharmaceuticals
  • PET and SPECT animal and human imaging
  • Experimental design and pharmacokinetic modeling
  • Validation and regulatory submission of compound for human use
The Core has synthesized over 20 compounds for clinical evaluation and routine use for neurology, cardiology and oncology. In addition, it has pioneered the use of 18F Tau imaging agents for neurodegenerative diseases such as Alzheimer’s disease and traumatic brain injuries.

List of Radiopharmaceuticals Available for Human and Animal Use
 

User Fees (effective 10/01/2017):

Services Internal User Fee for ​Non-Profit and Federal Sponsored Research (Direct Cost*)  Internal User Fee for Industry Sponsored Research (Direct Cost*) External User Fee for ​Non-Profit and Federal Sponsored Research (Inclusive of Institutional Indirect Cost*) External User Fee for Industry Sponsored Research (Inclusive of Institutional Indirect Cost*)
13N Ammonia Production + Imaging  $        3,765.00  $        5,647.50  $        5,421.60  Please contact PET Core for rate
13N2 PET GMP Production + Imaging  $        2,679.00  $        4,018.50  $        3,857.76  Please contact PET Core for rate
13N2 PET Production + Imaging  $        1,326.00  $        1,989.00  $        1,909.44  Please contact PET Core for rate
13 NH3 Cardiac Blood Flow  $        3,568.00  $        5,352.00  $        5,137.92  Please contact PET Core for rate
18F FDG Production + Imaging  $        2,141.00  $        3,211.50  $        3,083.04  Please contact PET Core for rate
Other PET GMP Production + Imaging  $        3,090.00  $        4,635.00  $        4,449.60  Please contact PET Core for rate
Other PET Production + Imaging  $        2,285.00  $        3,427.50  $        3,290.40  Please contact PET Core for rate
PET Imaging Only (up to two hours)  $        2,034.00  $        3,051.00  $        2,928.96  Please contact PET Core for rate
Additional Imaging Time (per hour)  $           432.00  $           648.00  $           622.08  Please contact PET Core for rate
Phantom Imaging  $        1,417.00  $        2,125.50  $        2,040.48  Please contact PET Core for rate
F18 Compound Dose (No Imaging)  $        2,033.00  $        3,049.50  $        2,927.52  Please contact PET Core for rate
Cyclotron Beam Time  Isotope Production (per hour)  $           878.00  $        1,317.00  $        1,264.32  Please contact PET Core for rate
Micro PET Imaging Only (up to 2 hours)  $           365.00  $           547.50  $           525.60  Please contact PET Core for rate
Micro PET Additional Imaging Hour  $           105.00  $           157.50  $           151.20  Please contact PET Core for rate
Blood Processing  $        1,022.00  $        1,533.00  $        1,471.68  Please contact PET Core for rate
Consent Charge  $             92.00  $           138.00  $           132.48  Please contact PET Core for rate
CT  $           974.00  $        1,461.00  $        1,402.56  Please contact PET Core for rate
IRB Renewal  $        3,266.00  $        4,899.00  $        4,703.04  Please contact PET Core for rate
Kinetic Modeling  $           995.00  $        1,492.50  $        1,432.80  Please contact PET Core for rate
Radionuclidic Purity Testing  $           352.00  $           528.00  $           506.88  Please contact PET Core for rate
Regulatory Submission  $        9,777.00  $      14,665.50  $      14,078.88  Please contact PET Core for rate
SALSA Generator Validation  $        2,650.00  $        3,975.00  $        3,816.00  Please contact PET Core for rate
SPECT  $        1,892.00  $        2,838.00  $        2,724.48  Please contact PET Core for rate
SPECT-CT  $        2,285.00  $        3,427.50  $        3,290.40  Please contact PET Core for rate
Start-up Fee  $        6,853.00  $      10,279.50  $        9,868.32  Please contact PET Core for rate
Technician Training / Site Qualification (per hour)  $           284.00  $           426.00  $           408.96  Please contact PET Core for rate
Validation of Radiotracer for Animal Use  $      14,186.00  $      21,279.00  $      20,427.84  Please contact PET Core for rate
Validation of Radiotracer for Human and NHP Use  $      25,343.00  $      38,014.50 $      36,493.92  Please contact PET Core for rate

Location


MGH Main Campus, Boston, MA: Edwards Basement (cyclotron and radiochemistry), White II (human and large animal imaging)
MGH Navy Yard Campus, Charlestown, 149 13th Street, Charlestown, MA (small animal imaging)

Major Equipment

Automated Radiochemical Synthesis systems
E.cam (Siemens) SPECT Systems and Planar Gamma Cameras
Exact HR+ Large Bore PET Scanner
NeuroPET/CT dedicated high sensitivity brain scanner
PC4096 Large Bore PET Scanner
Siemens PET/CT Scanner
Siemens Symbia SPECT/CT
VISTA small animal micro PET/CT



The Core commits its best efforts to successfully complete scheduled studies. However, given the very nature of many PET studies that rely on manufacturing of the radiopharmaceutical and in vivo imaging, the Core cannot cover costs associated with uncompleted studies due to equipment failure or circumstances outside of our control.

A fee can be charged in relation with a study in the event of a last minute cancellation or a no-show.

* A Partners investigator using a Partners fund is considered an internal user and will be subject to the institutional overhead rate applied by Partners Research Management. The external user fee comprises a direct fee negotiated with the PET Core plus an overhead component. The overhead rate set by Partners is 44% for external academic users and 59% for external industry users.


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Contact Us

For questions related to human and large animal imaging, please contact:
Steven Weise
Sr. Research Technologist, PET Imaging
Email: weise@pet.mgh.harvard.edu
Phone: 617-726-5299

For questions related to small animal imaging, please contact:
Julia Scotton, B.S., CNMT, RT(N)(CT)
Senior Research Technologist and Safety Manager
Email: jscotton@partners.org
Phone: 617-643-1967

For questions related to drug production, please contact:
Daniel Yokell, Pharm.D.
Manager, PET Production Chemistry
Phone: (617) 643-7541
Fax: (617) 726-5123
Email: dyokell@partners.org

For questions related to study budgets, invoices and payments, please contact:
Ramzi El Fakhri
Program Manager
Phone: 617-724-7212
Email: relfakhri@mgh.harvard.edu

For other inquiries, please contact:
Georges El Fakhri, Ph.D.
Director, MGH Gordon PET Core
Phone: (617) 726-9640
Fax: (617) 726-6165
Email: elfakhri@pet.mgh.harvard.edu