Recent Publications

Sepulcre article in Nature Medicine

Dr. Jorge Sepulcre, an Assistant Professor of Radiology at HMS and Assistant in Neuroscience at the MGH Gordon Center, leads a lab that focuses on brain imaging studies aimed at the understanding of large-scale brain networks implicated in human cognition and neurodegenerative disorders. His article titled “Neurogenetic contributions to amyloid beta and tau spreading in the human […]

Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain

Dr. Jorge Sepulcre, an Assistant Professor of Radiology at HMS and Assistant in Neuroscience at the MGH Gordon Center. His research focuses on large-scale brain networks implicated in human cognition and neurodegenerative disorders. His article titled “Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain” has been published in Nature Communications on the 24th of […]

Refining Models of Amyloid Accumulation in Alzheimer’s Disease

“PET staging of amyloidosis using striatum”: A new study published in Alzheimer’s and Dementia, the Journal of the Alzheimer’s Association, proposes to stage amyloid PET images using regional information. The research was conducted by Dr. Bernard Hanseeuw, instructor at MGH Gordon Center, and Dr. Keith Johnson, leader of the Aging NeuroImaging Program at the MGH Gordon Center, and the Harvard Aging Brain Study.

Novel PET Imaging Tracer May Improve Monitoring of Multiple Sclerosis

In a recent paper published by the journal Scientific Reports, Dr. Pedro Brugarolas and his colleagues describe the development and testing in animal models of a new PET tracer for demyelination. Their new tracer is based on the MS drug 4-aminopyridine (4AP, dalfampridine) which binds to potassium channels in demyelinated axons allowing the visualization of demyelinated lesions in animal models of MS noninvasively.

Improving PET Quantitation with Denoising, Motion Compensation, and Deblurring

This article was published in the Nuclear & Plasma Sciences Society newsletter of September 2017 Positron emission tomography (PET) enables 3D visualization of vital physiological information, e.g., metabolism, blood flow, and neuroreceptor concentration by using targeted radioisotope-labeled tracers. Quantitative interpretation of PET images is crucial both in diagnostic and therapeutic contexts. As a result of […]

Heat-induced-radiolabeling and click chemistry

Yuan H, Wilks MQ, El Fakhri G, Normandin MD, Kaittanis C, Josephson L (2017) Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials. PLoS ONE 12(2): e0172722. doi:10.1371/journal.pone.0172722 Abstract A key advantage of nanomaterials for biomedical applications is their ability to feature multiple small reporter groups (multimodality), or combinations of reporter groups and […]

Neuroplastic Changes in Blind Individuals

  This article was initially published by the RSNA Daily Bulletin on November 30, 2016. Dr. Laura Ortiz-Terán is a clinical radiologist and neuroimaging research scientist at the MGH Gordon Center. She works with Dr. Jorge Sepulcre to investigate the neuroplastic changes occurring in blind individuals, adults and children, using graph theory based resting-state functional […]

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