Biological systems are comprised of intricate molecules, cells and tissues. Understanding interactions of these components remains a major challenge in biology. In a conference organized by the Gordon Center, Dr. Kwanghun Chung from MIT introduced a new method that enables scalable proteomic imaging of intact systems without requiring any specialized equipment or reagents. The method, termed SWITCH, uniformly secures tissue architecture, native biomolecules, and antigenicity across an entire system by synchronizing the tissue preservation reaction. According to Dr. Chung, the heat and chemical resistant nature of the resulting framework permits virtually unlimited rounds of relabeling of a single tissue with precise co-registration of multiple datasets. Such integrated high-dimensional information may accelerate the understanding of biological systems at multiple levels.