Archive for September, 2018

Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain


Dr. Jorge Sepulcre, an Assistant Professor of Radiology at HMS and Assistant in Neuroscience at the MGH Gordon Center. His research focuses on large-scale brain networks implicated in human cognition and neurodegenerative disorders.

His article titled “Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain” has been published in Nature Communications on the 24th of September 2018.


Experimental and modeling work of neural activity has described recurrent and attractor dynamic patterns in cerebral microcircuits. However, it is still poorly understood whether similar dynamic principles exist or can be generalizable to the large-scale level. Here, we applied dynamic graph theory-based analyses to evaluate the dynamic streams of whole-brain functional connectivity over time across cognitive states. Dynamic connectivity in local networks is located in attentional areas during tasks and primary sensory areas during rest states, and dynamic connectivity in distributed networks converges in the default mode network (DMN) in both task and rest states. Importantly, we find that distinctive dynamic connectivity patterns are spatially associated with Allen Human Brain Atlas genetic transcription levels of synaptic long-term potentiation and long-term depression-related genes. Our findings support the neurobiological basis of large-scale attractor-like dynamics in the heteromodal cortex within the DMN, irrespective of cognitive state.


Raiyan Zaman receives WMIC award


Dr. Raiyan T. Zaman of the MGH Gordon Center won a WIMIN Award at the WMIC conference.

Dr. Zaman’s work on Harnessing Radioluminescence and Sound to Reveal Molecular Pathology of In Vivo Atherosclerotic Plaques received the Women in Molecular Imaging Network Scholar Award from the World Molecular Imaging Congress on September 2018. These prestigious awards are granted to presenters of meritorious scientific papers at WMIC Annual Meetings. This study was based on her K99 award funded by the NIH-NHLBI.

Raiyan Zaman receives AAPM award


Dr. Raiyan T. Zaman of the MGH Gordon Center was awarded the Science Council Session Award at the 2018 AAPM conference.

Dr. Zaman’s work on Distinctive Energy Profile of Water-Soluble, Thiolate-Protected Gold Nanoparticles as Potential Molecular Marker for XFCT Imaging received the Science Council Session Award from the American Association of Physicists in Medicine Conference on July 2018. This prestigious award was given to outstanding scientific abstract on a topic identified by Science Council as being the frontier of Medical Physics. Dr. Zaman collaborated with Dr. Roger Kornberg’s research team for their x-ray based nano-crystals.