Archive for February, 2017

Assessment and Management of Bulbar Motor Involvement Due to Amyotrophic Lateral Sclerosis


Dr. Jordan R. Green is the Director of the MGH IHP Speech and Feeding Disorders Lab, and holds academic appointments in the Departments of Communication Sciences and Disorders at MGH Institutes of Health Professions, and at the Speech & Hearing Biosciences and Technology program at the Harvard Medical School. Dr. Green was the guest speaker at a lecture organized by the MGH Gordon Center. Below is the presentation summary.

Progressive motor deterioration due to amyotrophic lateral sclerosis (ALS) leads to the eventual impairment of speech and swallowing function. Despite the devastating consequences of speech impairment to life quality, few options are available to objectively assess the integrity of the speech motor system and to assist impaired oral communication. The long-term goals of current research led by Dr. Green is to derive objective measures of speech performance that can be used to support diagnosis and clinical decision-making, and to develop new pathways of oral communication for the speech impaired (i.e., a real-time articulatory movement-driven speech synthesizer).

Dr. Jordan R. Green delivering his presentation at the MGH Gordon Center

Heat-induced-radiolabeling and click chemistry


Yuan H, Wilks MQ, El Fakhri G, Normandin MD, Kaittanis C, Josephson L (2017) Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials. PLoS ONE 12(2): e0172722. doi:10.1371/journal.pone.0172722


A key advantage of nanomaterials for biomedical applications is their ability to feature multiple small reporter groups (multimodality), or combinations of reporter groups and therapeutic agents (multifunctionality), while being targeted to cell surface receptors. Here a facile combination of techniques for the syntheses of multimodal, targeted nanoparticles (NPs) is presented, whereby heat-induced-radiolabeling (HIR) labels NPs with radiometals and socalled click chemistry is used to attach bioactive groups to the NP surface. Click-reactive alkyne or azide groups were first attached to the nonradioactive clinical Feraheme (FH) NPs. Resulting ªAlkyne-FHº and ªAzide-FHº intermediates, like the parent NP, tolerated 89Zr labeling by the HIR method previously described. Subsequently, biomolecules were quickly conjugated to the radioactive NPs by either copper-catalyzed or copper-free click reactions with high efficiency. Synthesis of the Alkyne-FH or Azide-FH intermediates, followed by HIR and then by click reactions for biomolecule attachment, provides a simple and potentially general path for the synthesis of multimodal, multifunctional, and targeted NPs for biomedical applications. Download Full Article in PDF

Outline of heat induced radiolabeling (HIR) and click chemistry surface functionalization used to obtain multimodal, targeted NPs.